format-version: 1.2
date: 16:04:2010 13:29
saved-by: Darren Natale, Robert Williams
auto-generated-by: OBO-Edit 2.0
default-namespace: dpo
remark: release: 0.02, version alpha, 11000 lines.
remark: Originated by Darren Natale using information from the Disprot database.
remark: To DPO-edit, load dpo.obo together with so.obo and evidence_code.obo.

[Term]
id: DPO:000001
name: structural_class
def: "." [DPO:curators]

[Term]
id: DPO:000002
name: function
def: "." [DPO:curators]

[Term]
id: DPO:000003
name: subfunction
def: "." [DPO:curators]

[Term]
id: DPO:000004
name: structural_basis_for_function
def: "." [DPO:curators]

[Term]
id: DPO:000005
name: detection_method
def: "." [DPO:curators]
synonym: "evidence_code" EXACT [ECO:0000000]

[Term]
id: DPO:000006
name: ordered region
namespace: structural_class
def: "." [DPO:curators]
is_a: DPO:000001 ! structural_class

[Term]
id: DPO:000007
name: disordered region
namespace: structural_class
def: "." [DPO:curators]
is_a: DPO:000001 ! structural_class

[Term]
id: DPO:000008
name: disordered - extended region
namespace: structural_class
def: "." [DPO:curators]
is_a: DPO:000001 ! structural_class

[Term]
id: DPO:000009
name: disordered - pre-molten globule region
namespace: structural_class
def: "." [DPO:curators]
is_a: DPO:000001 ! structural_class

[Term]
id: DPO:000010
name: disordered - molten globule region
namespace: structural_class
def: "." [DPO:curators]
is_a: DPO:000001 ! structural_class

[Term]
id: DPO:000011
name: chaperone
namespace: function
def: "Help other proteins or RNA in achieving proper folded state; prevent protein aggregation; help misfolded proteins to refold." [DPO:curators]
is_a: DPO:000002 ! function

[Term]
id: DPO:000012
name: entropic chain
namespace: function
def: "Function as a result of disorder, often connecting two ordered domains and allow regulation of the distance between them." [DPO:curators]
is_a: DPO:000002 ! function

[Term]
id: DPO:000013
name: metal sponge
namespace: function
def: "Store and help remove/neutralize heavy metals for detoxification." [DPO:curators]
is_a: DPO:000002 ! function

[Term]
id: DPO:000014
name: modification site
namespace: function
def: "Permits protein modification, either by chemical additions or by protease cleavage." [DPO:curators]
is_a: DPO:000002 ! function

[Term]
id: DPO:000015
name: molecular assembly
namespace: function
def: "Assemble, regulate, and stabilize protein complexes." [DPO:curators]
is_a: DPO:000002 ! function

[Term]
id: DPO:000016
name: molecular recognition effector
namespace: function
def: "Allow the binding of multiple partners with high specificity and low affinity, and is commonly used for signaling." [DPO:curators]
is_a: DPO:000002 ! function

[Term]
id: DPO:000017
name: molecular recognition scavenger
namespace: function
def: "Store and/or neutralize their ligands." [DPO:curators]
is_a: DPO:000002 ! function

[Term]
id: DPO:000018
name: acetylation
namespace: subfunction
def: "Guides the addition of an acetyl group during chemical modification of the protein." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000019
name: ADP-ribosylation
namespace: subfunction
def: "Regulates vesicle biogenesis in intracellular traffic; may modulate vesicle budding and uncoating within the Golgi apparatus; is involved in protein trafficking." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000020
name: apoptosis
namespace: subfunction
def: "Regulation Regulation of cell fate." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000021
name: autoregulatory
namespace: subfunction
def: "Involved in the regulation of protein function/activity." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000022
name: cofactor/heme binding
namespace: subfunction
def: "Binds to the appropriate cofactor(s) and/or heme(s)." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000023
name: disordered region is not essential for protein function
namespace: subfunction
def: "Region has been shown experimentally to perform no function." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000024
name: DNA bending
namespace: subfunction
def: "Mediates DNA bending." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000025
name: DNA unwinding
namespace: subfunction
def: "Promotes the unwinding of DNA." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000026
name: electron transfer
namespace: subfunction
def: "Participates in the electron transfer." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000027
name: entropic bristle
namespace: subfunction
def: "A disordered region that creates a zone of exclusion by its entropic movement." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000028
name: entropic clock
namespace: subfunction
def: "Provide a timing mechanism arising from random searches such as those observed in the ball-and-chain model for closure of voltage-gated ion channels." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000029
name: entropic spring
namespace: subfunction
def: "Provides a restoring force resulting from randomization of bond torsion angles that become restricted upon stretching." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000030
name: fatty acylation (myristolation and palmitoylation)
namespace: subfunction
def: "Guides the addition of a fatty acyl group during chemical modification of the protein." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000031
name: flexible linker/spacer
namespace: subfunction
def: "Provides separation and permits movement between adjacent domains." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000032
name: glycosylation
namespace: subfunction
def: "Guides the addition of a sugar, such as a glycan, during chemical modification of the protein." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000033
name: intraprotein interaction
namespace: subfunction
def: "Directs the binding of the disordered region to another location within the parent protein." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000034
name: metal binding
namespace: subfunction
def: "Binds to metal ions." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000035
name: methylation
namespace: subfunction
def: "Guides the addition of a methyl group during chemical modification of the protein." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000036
name: nuclear localization
namespace: subfunction
def: "Acts as a tag on the protein surface to confine the protein to the cell nucleus through the nuclear pore complex." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000037
name: phosphorylation
namespace: subfunction
def: "Guides the addition of a phosphate to the protein." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000038
name: polymerization
namespace: subfunction
def: "Facilitates polymerization." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000039
name: protein detergent
namespace: subfunction
def: "Binds to hydrophobic groups, thus making them more soluble." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000040
name: protein-DNA binding
namespace: subfunction
def: "Binds to DNA." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000041
name: protein-genomic RNA binding
namespace: subfunction
def: "Binds to genomic RNA." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000042
name: protein-lipid interaction
namespace: subfunction
def: "Located at the interface of the protein and its lipid partner." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000043
name: protein-mRNA binding
namespace: subfunction
def: "Binds to mRNA." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000044
name: protein-protein binding
namespace: subfunction
def: "Binds to the protein partner(s)." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000045
name: protein-rRNA binding
namespace: subfunction
def: "Binds to rRNA." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000046
name: protein-tRNA binding
namespace: subfunction
def: "Binds to tRNA." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000047
name: regulation of proteolysis in vivo
namespace: subfunction
def: "Directs protein lysis under physiological conditions within the cell." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000048
name: self-transport through channel
namespace: subfunction
def: "Allows movement of proteins through membrane channels." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000049
name: structural mortar
namespace: subfunction
def: "Ribosomal proteins that fill the gaps and cracks of rRNA." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000050
name: substrate/ligand binding
namespace: subfunction
def: "Binds to substrate(s) and/or ligand(s)." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000051
name: transactivation (transcriptional activation)
namespace: subfunction
def: "Mediates transcriptional activation." [DPO:curators]
is_a: DPO:000003 ! subfunction

[Term]
id: DPO:000052
name: ordered state
namespace: structural_basis_for_function
def: "Function arises from the ordered state." [DPO:curators]
is_a: DPO:000004 ! structural_basis_for_function

[Term]
id: DPO:000053
name: disordered state
namespace: structural_basis_for_function
def: "Function arises from the disordered state." [DPO:curators]
is_a: DPO:000004 ! structural_basis_for_function

[Term]
id: DPO:000054
name: pre-molten globule state
namespace: structural_basis_for_function
def: "Function arises from the pre-molten globule state." [DPO:curators]
is_a: DPO:000004 ! structural_basis_for_function

[Term]
id: DPO:000055
name: molten globule state
namespace: structural_basis_for_function
def: "Function arises from the molten globule state." [DPO:curators]
is_a: DPO:000004 ! structural_basis_for_function

[Term]
id: DPO:000056
name: disorder to order transition
namespace: structural_basis_for_function
def: "Function arises via a disorder to order transition." [DPO:curators]
is_a: DPO:000004 ! structural_basis_for_function

[Term]
id: DPO:000057
name: pre-molten globule to order transition
namespace: structural_basis_for_function
def: "Function arises via a pre-molten globule to order transition." [DPO:curators]
is_a: DPO:000004 ! structural_basis_for_function

[Term]
id: DPO:000058
name: molten globule to order transition
namespace: structural_basis_for_function
def: "Function arises via a molten globule to order transition." [DPO:curators]
is_a: DPO:000004 ! structural_basis_for_function

[Term]
id: DPO:000059
name: order to disorder transition
namespace: structural_basis_for_function
def: "Function arises via an order to disorder transition." [DPO:curators]
is_a: DPO:000004 ! structural_basis_for_function

[Term]
id: DPO:000060
name: pre-molten globule to disorder transition
namespace: structural_basis_for_function
def: "Function arises via a pre-molten globule to disorder transition." [DPO:curators]
is_a: DPO:000004 ! structural_basis_for_function

[Term]
id: DPO:000061
name: molten globule to disorder transition
namespace: structural_basis_for_function
def: "Function arises via a molten globule to disorder transition." [DPO:curators]
is_a: DPO:000004 ! structural_basis_for_function

[Term]
id: DPO:000062
name: order to pre-molten globule transition
namespace: structural_basis_for_function
def: "Function arises via an order to pre-molten globule transition." [DPO:curators]
is_a: DPO:000004 ! structural_basis_for_function

[Term]
id: DPO:000063
name: disorder to pre-molten globule transition
namespace: structural_basis_for_function
def: "Function arises via a disorder to pre-molten globule transition." [DPO:curators]
is_a: DPO:000004 ! structural_basis_for_function

[Term]
id: DPO:000064
name: molten globule to pre-molten globule transition
namespace: structural_basis_for_function
def: "Function arises via a molten globule to pre-molten globule transition." [DPO:curators]
is_a: DPO:000004 ! structural_basis_for_function

[Term]
id: DPO:000065
name: order to molten globule transition
namespace: structural_basis_for_function
def: "Function arises via an order to molten globule transition." [DPO:curators]
is_a: DPO:000004 ! structural_basis_for_function

[Term]
id: DPO:000066
name: disorder to molten globule transition
namespace: structural_basis_for_function
def: "Function arises via a disorder to molten globule transition." [DPO:curators]
is_a: DPO:000004 ! structural_basis_for_function

[Term]
id: DPO:000067
name: pre-molten globule to molten globule transition
namespace: structural_basis_for_function
def: "Function arises via a pre-molten globule to molten globule transition." [DPO:curators]
is_a: DPO:000004 ! structural_basis_for_function

[Term]
id: DPO:000068
name: aberrant mobility on SDS-PAGE gel
namespace: detection_method
def: "Aberrant mobility on SDS-PAGE gels is an indication that the protein under study is disordered. However, this is not a definitive method and should be treated as supporting evidence." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000069
name: analytical ultracentrifugation
namespace: detection_method
def: "This method is based on the visualization the behavior of a particle in real time during sedimentation, allowing extremely accurate determination of hydrodynamic and thermodynamic parameters, as well as estimation of the molecular weight of proteins. These can then be compared with the size of a globular protein of the same mass. It is also useful in monitoring changes in conformation of the proteins." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000070
name: dynamic light scattering
namespace: detection_method
def: "Passes a beam of light through a sample, and then measures the extent of the scattering. This provides information on the hydrodynamic radius of the protein, which is dependent upon the size and conformation of the protein." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000071
name: dynamic quenching
namespace: detection_method
def: "The use of chemical or physical means to depopulate the excited state without allowing fluorescence emission. It can provide information on the accessibility of internal chromophores (i.e. tryptophan, tyrosine, phenylalanine) to solvent, and thus describes the relative compactness and dynamics of a protein molecule." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000072
name: far-UV circular dichroism (CD)
namespace: detection_method
def: "Detects the presence or absence of ordered secondary structure and can be used to estimate the secondary structure content in a given protein. CD spectra of natively unfolded proteins, being measured in the far ultraviolet region, show a large negative peak around 200 nm, as well as a value near zero at 220 nm in partially or fully unstructured proteins. These values are distinct enough to distinguish them from ordered proteins." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000073
name: fluorescence anisotropy
namespace: detection_method
def: "Measurement of the difference between the fluorescent intensities of parallel and perpendicular polarization when compared to the initial, excitation polarization. These measurements can be done for internal chromophores (i.e. tryptophan, tyrosine, phenylalanine) as well as for external chromophores (covalently bound fluorescent labels or dyes). They can give information on speed of chromophore rotation within the molecule and thus provide information on the mobility and orientation of the protein." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000074
name: fluorescence resonance energy transfer
namespace: detection_method
def: "Monitors the irradiative transfer of energy between two chromophores. This is used to determine the distance between the two fluorescence labels. Conformational flexibility (and hence disorder) is observed as changes in this distance." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000075
name: fluorescent probe
namespace: detection_method
def: "A rigid structure of well-folded protein will not allow access of fluorescent probes (usually large hydrophobic molecules) into the folded core, but a molten globular structure will allow the probe to penetrate. Incorporation of the probe into the core alters the environment of the probe, which can be detected as changes in fluorescence." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000076
name: fourier transform infrared spectroscopy
namespace: detection_method
def: "Presents information on the vibrational movements of functional groups due to bond stretching, change of bond angles, and other types of motion. It can then be compared to experimental data obtained from defined secondary structures (such as alpha helices and beta sheets), and thus can identify secondary characteristics outside the realm of these ordered sets." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000077
name: gel filtration/size exclusion chromatography
namespace: detection_method
def: "Separates proteins on the basis of their molecular size and hydrodynamic volumes." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000078
name: high relative B-factor
namespace: detection_method
def: "Refers to the degree in which the electron density is spread out for individual atoms or groups of atoms within a sample. Displacement of atoms results in higher B-factors, which indicate higher relative disorder." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000079
name: hydrogen-deuterium Exchange
namespace: detection_method
def: "Monitors the exchange rate between deuterium in the solvent and hydrogen in the main chain amides. These rates are affected by hydrogen bonding, accessibility of the amides to the surface, and flexibility of the protein. Faster exchange rates indicate the more flexible (and potentially disordered) protein." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000080
name: immunochemistry
namespace: detection_method
def: "Immunochemical methods may also be applied toward the elucidation of protein disorder. Important to this discussion, the immunoglobulins obtained against a given protein may be specific for different levels of macromolecule: the primary structure, the secondary structure, or the tertiary structure. Thus, antibodies may be successfully used to study the structural state of a protein." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000081
name: infrared spectroscopy
namespace: detection_method
def: "Presents information on the vibrational movements of functional groups due to bond stretching, change of bond angles, and other types of motion. It can then be compared to experimental data obtained from defined secondary structures (such as alpha helices and beta sheets), and thus can identify secondary characteristics outside the realm of these ordered sets." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000082
name: insensitivity to pH extreme
namespace: detection_method
def: "Intrinsically unstructured proteins, typically with extended forms and often with high percentages of charged residues, do not undergo large-scale structural changes when subjected to changes in pH. Unlike intrinsically unfolded proteins, structured proteins typically contain large numbers of hydrophobic residues that upon exposure due to pH-induced loosening of the structure, promote aggregation and precipitation." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000083
name: intrinsic fluorescence
namespace: detection_method
def: "Three amino acids exhibit intrinsic fluorescence: tryptophan, tyrosine and phenylalanine (ranked here in order of decreasing quantum yield) with tryptophan being the most commonly used. Quenching of tyrosine fluorescence can be due to ionization, to proximity to amide or carboxyl groups, or to the energy transfer to tryptophan. Application of intrinsic fluorescence to the study of protein conformational analysis relies on the fact that the parameters of tryptophan emission (intensity and wavelength of maximal fluorescence) depend essentially on environmental factors, including solvent polarity, pH, and presence or absence of quenchers. For example, a completely solvated tryptophan residue (e.g., free tryptophan in water or tryptophan in an unfolded polypeptide chain) has a maximum fluorescence in the vicinity of 350 nm, but embedding in the nonpolar interior of a compact globular protein results in a characteristic blue shift." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000084
name: mass spectrometry-based high resolution hydrogen-deuterium exchange
namespace: detection_method
def: "Measures the hydrogen-deuterium exchange rate for a given protein, but does not require crystals (as in X-ray crystallography) and is not limited to protein size and sample concentration (as in NMR). These exchange rates are affected by hydrogen bonding, accessibility of the protein surface, and flexibility of the protein. A faster exchange rate indicates that the protein is less stable, more flexible and may be disordered." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000085
name: near-UV circular dichroism (CD) spectroscopy
namespace: detection_method
def: "Indications of protein tertiary structure can be obtained by assaying the solvent accessibility of one type of optically active chromophores in proteins (side groups of aromatic amino acid residues. CD spectra in the near ultraviolet region (250.350 nm), also called the aromatic region, reflect the symmetry of the environment of aromatic amino acid residues. A highly symmetrical environment indicates solvent accessibility. Protein denaturation (where the normally protected hydrophobic core of a globular protein becomes exposed to the solvent) can be monitored by changes in the near-UV CD spectrum." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000086
name: nuclear magnetic resonance (NMR)
namespace: detection_method
def: "Heteronuclear multidimensional NMR is an extremely powerful technique for three-dimensional structure determination of proteins in solution. Regions of high backbone flexibility have reduced chemical shift dispersion indicative of disorder. Spin relaxation and nuclear Overhauser effect measurements can provide information on the molecular dynamics of the disordered region. Recent advances have allowed the complete assignment of resonances for several unfolded proteins as well as some disordered fragments of some folded proteins." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000087
name: optical rotatory dispersion
namespace: detection_method
def: "Measures the optical dispersion caused by a protein, in which the wavelength of the light is varied. This takes advantage of the fact that right and left handed molecules cause different rotational effects on the polarized light. This can be used to determine the presence and amount of secondary structures, such as alpha helices." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000088
name: radio-labelled Activity Assay
namespace: detection_method
def: "Detection of enzymatic activity using radio-labelled proteins or substrates. Reaction products are separated on gels by electrophoresis, phosphor-imaged, then visualized and quantified using relevant computer software. Comparing activity of native vs. modified proteins can indicate protein function(s)." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000089
name: raman optical activity
namespace: detection_method
def: "Raman optical activity can be used to provide information on secondary structure. Raman optical activity provides a means to distinguish between dynamic (flexible chain) and static disorder (structured domain tethered by a hinge region)." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000090
name: raman spectroscopy
namespace: detection_method
def: "Raman spectroscopy can be used to measure secondary structure content in the same way that is used for FTIR. The Raman spectrum of an unfolded peptide or protein is distinct from that of other forms of secondary." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000091
name: rotory shadowing electron microscopy
namespace: detection_method
def: "In this technique, a protein sample is coated with a heavy metal, such as platinum. These metals block the electron beams used in TEM, and can reveal the shape of the protein. As the source of the metal lies at an angle to the sample surface, the thickness of the accumulated metal varies with the surface topography. By rotating the sample while coating with the metal, the 3D characteristics of the sample can be observed in high resolution." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000092
name: sensitivity to proteolysis
namespace: detection_method
def: "Unstructured proteins have increased proteolytic degradation rates in vitro due to their increased flexibility which allows unfettered access to the chain by proteases." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000093
name: small-angle neutron scattering
namespace: detection_method
def: "Neutrons are passed through an aqueous solution containing a protein sample, which causes a scattering effect. The results can then be used to obtain details on the size, shape, and orientation of the protein. Neutron scattering provides a means of measuring on scales much smaller than light scattering because of the smaller size of the neutron wavelengths." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000094
name: small-angle X-ray scattering
namespace: detection_method
def: "The degree of globularity, which reflects the presence or absence of a tightly packed core in a protein molecule, can be extracted from the analysis of SAXS data in the form of a Kratky plot, whose shape is sensitive to the conformational state of the scattering protein molecules. It has been shown that a scattering curve in the Kratky coordinates has a characteristic maximum for globular proteins in either their native or molten globule states (i.e., states with globular structure). However, if a protein is completely unfolded or in a premolten globule conformation (i.e., with no globular structure), such a maximum will be absent." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000095
name: static light scattering
namespace: detection_method
def: "This method is based on passing a beam of light through a sample, and then measuring the extent of the scattering at one specific scattering angle. This provides information on the hydrodynamic radius of the protein, which is dependent upon the size and conformation of the protein." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000096
name: thermal stability
namespace: detection_method
def: "Structured proteins are generally denatured by heat, whereas high temperatures might induce folding in disordered proteins. This induced folding is believed to be a result of increased hydrophobic interactions, which leads to a greater hydrophobic driving force for protein folding." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000097
name: viscometry
namespace: detection_method
def: "The viscosity of a sample, which is the degree to which it resists flow under an applied force, is affected by the molecular weight of a protein and its shape and conformation. By comparing the behavior of a protein to those of known structure and similar size, the relative disorder of a protein can be determined." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000098
name: X-ray crystallography
namespace: detection_method
def: "Missing electron density of backbone atoms found in three-dimensional structures determined by X-ray crystallography can indicate disordered regions. The increased flexibility of atoms in such regions leads to noncoherent X-ray scattering, preventing them from being observed." [DPO:curators]
is_a: DPO:000005 ! detection_method

[Term]
id: DPO:000099
name: 60S acidic ribosomal protein P1-B region 1
namespace: region
def: "." [DPO:curators, PMID:15182941]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000100
name: 60S acidic ribosomal protein P2-beta region 1
namespace: region
def: "." [DPO:curators, PMID:9236009, PMID:10913306]
is_a: DPO:000010 ! disordered - molten globule region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000058 ! molten globule to order transition

[Term]
id: DPO:000101
name: early E2A DNA-binding protein region 1
namespace: region
def: "." [DPO:curators, PMID:9545375, PMID:8039495, PMID:4040872]
comment: This region is known as the flexible loop.  It goes from disordered to ordered upon binding to DNA, helps to stabilize the binding complex and plays an important role in DNA replication. 
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000025 ! DNA unwinding
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000102
name: early E2A DNA-binding protein region 2
namespace: region
def: "." [DPO:curators, PMID:9545375, PMID:8039495, PMID:4040872]
comment: This region is part of the C-terminal portion of the protein which is important in chain formation and DNA replication.
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000103
name: early E2A DNA-binding protein region 3
namespace: region
def: "." [DPO:curators, PMID:9545375, PMID:8039495, PMID:4040872]
comment: This region is part of the C-terminal portion of the protein which is important for chain formation and DNA replication.
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000104
name: early E2A DNA-binding protein region 4
namespace: region
def: "." [DPO:curators, PMID:8039495, PMID:9545375, PMID:4040872]
is_a: DPO:000006 ! ordered region

[Term]
id: DPO:000105
name: early E2A DNA-binding protein region 5
namespace: region
def: "." [DPO:curators, PMID:9545375, PMID:8039495, PMID:4040872]
is_a: DPO:000006 ! ordered region

[Term]
id: DPO:000106
name: early E2A DNA-binding protein region 6
namespace: region
def: "." [DPO:curators, PMID:9545375, PMID:8039495, PMID:4040872]
is_a: DPO:000006 ! ordered region

[Term]
id: DPO:000107
name: early E2A DNA-binding protein region 7
namespace: region
def: "." [DPO:curators, PMID:9545375, PMID:8039495, PMID:4040872]
is_a: DPO:000006 ! ordered region

[Term]
id: DPO:000108
name: cathelicidin antimicrobial peptide region 1
namespace: region
def: "." [DPO:curators, PMID:9452503]
comment: The disordered region became significantly more disordered below pH 5.  At pH of 2, it was completely disordered.  At pH of 13, it adopted a helical structure.
is_a: DPO:000008 ! disordered - extended region
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000109
name: antitermination protein N region 1
namespace: region
def: "." [DPO:curators, PMID:9659923]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000110
name: cytochrome c region 1
namespace: region
def: "." [DPO:curators, PMID:4344990]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000111
name: DNA-(apurinic or apyrimidinic site) lyase region 1
namespace: region
def: "." [DPO:curators, PMID:11286553]
comment: This structure is refered to as 'form II' in Beernink (2001).
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000004127 ! DNA-(apurinic or apyrimidinic site) lyase
relationship: has_subfunction DPO:000023 ! disordered region is not essential for protein function

[Term]
id: DPO:000112
name: DNA-(apurinic or apyrimidinic site) lyase region 2
namespace: region
def: "." [DPO:curators, PMID:9351835]
comment: This structure is refered to as 'form I' in Beernink (2001). The experimental sequence did not contain the N-terminal residues 1-35.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000004127 ! DNA-(apurinic or apyrimidinic site) lyase
relationship: has_subfunction DPO:000023 ! disordered region is not essential for protein function

[Term]
id: DPO:000113
name: DNA-(apurinic or apyrimidinic site) lyase region 3
namespace: region
def: "." [DPO:curators, PMID:11286553]
comment: This structure is refered to as 'form II' in Beernink (2001).
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000004127 ! DNA-(apurinic or apyrimidinic site) lyase

[Term]
id: DPO:000114
name: DNA-(apurinic or apyrimidinic site) lyase region 4
namespace: region
def: "." [DPO:curators, PMID:11286553]
comment: This structure is refered to as 'form II' in Beernink (2001).
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000004127 ! DNA-(apurinic or apyrimidinic site) lyase

[Term]
id: DPO:000115
name: DNA-(apurinic or apyrimidinic site) lyase region 5
namespace: region
def: "." [DPO:curators, PMID:11286553]
comment: This structure is refered to as 'form I' in Beernink (2001). The experimental sequence did not contain the N-terminal residues 1-35.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000004127 ! DNA-(apurinic or apyrimidinic site) lyase

[Term]
id: DPO:000116
name: DNA-(apurinic or apyrimidinic site) lyase region 6
namespace: region
def: "." [DPO:curators, PMID:9351835]
comment: This region is not essential for function (Gorman 1997). This structure is refered to as 'form III' in Beernink (2001)
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000004127 ! DNA-(apurinic or apyrimidinic site) lyase
relationship: has_subfunction DPO:000023 ! disordered region is not essential for protein function

[Term]
id: DPO:000117
name: POU domain class 2-associating factor 1 region 1
namespace: region
def: "." [DPO:curators, PMID:10329190]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000013034 ! POU domain class 2-associating factor 1

[Term]
id: DPO:000118
name: transcription initiation factor IIA small subunit region 1
namespace: region
def: "." [DPO:curators, PMID:8610010]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000119
name: sulfotransferase 1A3/1A4 region 1
namespace: region
def: "." [DPO:curators, PMID:10543947]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000015820 ! sulfotransferase 1A3/1A4
relationship: has_function DPO:000013 ! metal sponge
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000120
name: sulfotransferase 1A3/1A4 region 2
namespace: region
def: "." [DPO:curators, PMID:10543947]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000015820 ! sulfotransferase 1A3/1A4
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000121
name: sulfotransferase 1A3/1A4 region 3
namespace: region
def: "." [DPO:curators, PMID:10543947]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000015820 ! sulfotransferase 1A3/1A4
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000122
name: sulfotransferase 1A3/1A4 region 4
namespace: region
def: "." [DPO:curators, PMID:10543947]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000015820 ! sulfotransferase 1A3/1A4
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000123
name: sulfotransferase 1A3/1A4 region 5
namespace: region
def: "." [DPO:curators, PMID:10543947]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000015820 ! sulfotransferase 1A3/1A4
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000124
name: sulfotransferase 1A3/1A4 region 6
namespace: region
def: "." [DPO:curators, PMID:10543947]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000015820 ! sulfotransferase 1A3/1A4
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000125
name: sulfotransferase 1A3/1A4 region 7
namespace: region
def: "." [DPO:curators, PMID:10543947]
is_a: DPO:000006 ! ordered region
relationship: part_of PRO:000015820 ! sulfotransferase 1A3/1A4

[Term]
id: DPO:000126
name: sulfotransferase 1A3/1A4 region 8
namespace: region
def: "." [DPO:curators, PMID:10543947]
is_a: DPO:000006 ! ordered region
relationship: part_of PRO:000015820 ! sulfotransferase 1A3/1A4

[Term]
id: DPO:000127
name: sulfotransferase 1A3/1A4 region 9
namespace: region
def: "." [DPO:curators, PMID:10543947]
is_a: DPO:000006 ! ordered region
relationship: part_of PRO:000015820 ! sulfotransferase 1A3/1A4

[Term]
id: DPO:000128
name: sulfotransferase 1A3/1A4 region 10
namespace: region
def: "." [DPO:curators, PMID:10543947]
is_a: DPO:000006 ! ordered region
relationship: part_of PRO:000015820 ! sulfotransferase 1A3/1A4

[Term]
id: DPO:000129
name: cystic fibrosis transmembrane conductance regulator region 1
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000001044 ! cystic fibrosis transmembrane conductance regulator (cftr)

[Term]
id: DPO:000130
name: choriogonadotropin subunit beta region 1
namespace: region
def: "." [DPO:curators, PMID:8202136]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000005391 ! choriogonadotropin subunit beta

[Term]
id: DPO:000131
name: clusterin region 1
namespace: region
def: "." [DPO:curators, PMID:11570883]
comment: This protein has been determined disordered based on numerous experimental results that indicate it contains flexible loops.  However, no exact amino acid locations of disorder are known and the domains specified were based on PONDR predictions.  
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000039 ! protein detergent

[Term]
id: DPO:000132
name: clusterin region 2
namespace: region
def: "." [DPO:curators, PMID:11570883]
comment: This protein has been determined disordered based on numerous experimental results that indicate it contains flexible loops.  However, no exact amino acid locations of disorder are known and the domains specified were based on PONDR predictions.  
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000039 ! protein detergent

[Term]
id: DPO:000133
name: clusterin region 3
namespace: region
def: "." [DPO:curators, PMID:11570883]
comment: This protein has been determined disordered based on numerous experimental results that indicate it contains flexible loops.  However, no exact amino acid locations of disorder are known and the domains specified were based on PONDR predictions.  
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000039 ! protein detergent

[Term]
id: DPO:000134
name: cAMP-dependent protein kinase inhibitor alpha region 1
namespace: region
def: "." [DPO:curators, PMID:1862343, PMID:2040607]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000135
name: cyclin-dependent kinase inhibitor 1 region 1
namespace: region
def: "." [DPO:curators, PMID:8876165, PMID:9297835]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000005274 ! cyclin-dependent kinase inhibitor 1
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000136
name: cyclin-dependent kinase inhibitor 1C region 1
namespace: region
def: "." [DPO:curators, PMID:9251023, PMID:11746698]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000005275 ! cyclin-dependent kinase inhibitor 1C
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000137
name: cyclin-dependent kinase inhibitor 1C region 2
namespace: region
def: "." [DPO:curators, PMID:11746698, PMID:9251023]
comment: This fragment had 90% inhibition activity towards A-CDK2.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000005275 ! cyclin-dependent kinase inhibitor 1C
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000138
name: cyclin-dependent kinase inhibitor 1B region 1
namespace: region
def: "." [DPO:curators, PMID:15024385, PMID:8684460]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003090 ! cyclin-dependent kinase inhibitor 1B

[Term]
id: DPO:000139
name: cytochrome b-c1 complex subunit Rieske, mitochondrial region 1
namespace: region
def: "." [DPO:curators, PMID:9651245]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000140
name: DNA-binding protein RAP1 region 1
namespace: region
def: "." [DPO:curators, PMID:8620531]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000141
name: elongation factor G region 1
namespace: region
def: "." [DPO:curators, PMID:11054294]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000142
name: elongation factor G region 2
namespace: region
def: "." [DPO:curators, PMID:11054294]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000143
name: EMB-1 protein region 1
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000144
name: estradiol 17-beta-dehydrogenase 1 region 1
namespace: region
def: "." [DPO:curators, PMID:8756321, PMID:7663947, PMID:10625652, PMID:9927655]
comment: The 3DHE:A PDB file gives this protein fragment as complexed with Dehydroepiandrosterone. The 1DHT:A PDB file gives this protein fragment as complexed with Dihydrotestosterone. The 1IOL PDB file gives this protein fragment as complexed with Estradiol. The 1BHS PDB file gives the amino acid sequence for the uncomplexed, unmutated crystal structure of this protein.  
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000008773 ! estradiol 17-beta-dehydrogenase 1

[Term]
id: DPO:000145
name: estradiol 17-beta-dehydrogenase 1 region 2
namespace: region
def: "." [DPO:curators, PMID:8756321]
comment: The 1IOL PDB file gives this protein fragment as complexed with Estradiol.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000008773 ! estradiol 17-beta-dehydrogenase 1
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000050 ! substrate/ligand binding

[Term]
id: DPO:000146
name: estradiol 17-beta-dehydrogenase 1 region 3
namespace: region
def: "." [DPO:curators, PMID:8805577]
comment: The 1FDT PDB gives this protein fragment as complexed with 17-Beta-Estradiol and NADP+ at low temperature, 123 K.  The 1FDS PDB file gives this protein fragment as complexed with 17-Beta-Estradiol at room temperature.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000008773 ! estradiol 17-beta-dehydrogenase 1
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000023 ! disordered region is not essential for protein function
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000147
name: estradiol 17-beta-dehydrogenase 1 region 4
namespace: region
def: "." [DPO:curators, PMID:8805577]
comment: The 1FDT PDB gives this protein fragment as complexed with 17-Beta-Estradiol and NADP+ at low temperature, 123 K.  The 1FDS PDB file gives this protein fragment as complexed with 17-Beta-Estradiol at room temperature.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000008773 ! estradiol 17-beta-dehydrogenase 1
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000023 ! disordered region is not essential for protein function
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000148
name: estradiol 17-beta-dehydrogenase 1 region 5
namespace: region
def: "." [DPO:curators, PMID:8805577, PMID:12490543, PMID:12223444, PMID:9525918]
comment: The 1I5R:A PDB file gives this protein as complexed with an 8-methylene-based inhibitor- an EM-1745 complex. The 1JTV:A PDB file gives this protein fragment as complexed with testosterone. The 1FDW PDB file gives this protein fragment as complexed with Estradiol and has the mutation H221Q. The 1FDT PDB file gives this protein fragment as complexed with 17-Beta-Estradiol and NADP+ at low temperature, 123 K. The experimental sequence used for PDB ID 1FDV contained a H221L substitution.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000008773 ! estradiol 17-beta-dehydrogenase 1
relationship: has_subfunction DPO:000023 ! disordered region is not essential for protein function
relationship: has_subfunction DPO:000042 ! protein-lipid interaction

[Term]
id: DPO:000149
name: estradiol 17-beta-dehydrogenase 1 region 6
namespace: region
def: "." [DPO:curators, PMID:8805577]
comment: The 1FDT PDB gives this protein fragment as complexed with 17-Beta-Estradiol and NADP+ at low temperature, 123 K.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000008773 ! estradiol 17-beta-dehydrogenase 1
relationship: has_subfunction DPO:000023 ! disordered region is not essential for protein function
relationship: has_subfunction DPO:000042 ! protein-lipid interaction

[Term]
id: DPO:000150
name: estradiol 17-beta-dehydrogenase 1 region 7
namespace: region
def: "." [DPO:curators, PMID:8805577]
comment: The 1FDT PDB gives this protein fragment as complexed with 17-Beta-Estradiol and NADP+ at low temperature, 123 K.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000008773 ! estradiol 17-beta-dehydrogenase 1
relationship: has_subfunction DPO:000023 ! disordered region is not essential for protein function
relationship: has_subfunction DPO:000042 ! protein-lipid interaction

[Term]
id: DPO:000151
name: estradiol 17-beta-dehydrogenase 1 region 8
namespace: region
def: "." [DPO:curators, PMID:8805577]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000008773 ! estradiol 17-beta-dehydrogenase 1
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000050 ! substrate/ligand binding

relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000152
name: estradiol 17-beta-dehydrogenase 1 region 9
namespace: region
def: "." [DPO:curators, PMID:8805577]
comment: The 1FDT PDB gives this protein fragment as complexed with 17-Beta-Estradiol and NADP+ at low temperature, 123 K. 
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000008773 ! estradiol 17-beta-dehydrogenase 1
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000153
name: estradiol 17-beta-dehydrogenase 1 region 10
namespace: region
def: "." [DPO:curators, PMID:9525918]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000008773 ! estradiol 17-beta-dehydrogenase 1
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000023 ! disordered region is not essential for protein function
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000154
name: estradiol 17-beta-dehydrogenase 1 region 11
namespace: region
def: "." [DPO:curators, PMID:9525918]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000008773 ! estradiol 17-beta-dehydrogenase 1
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000155
name: estradiol 17-beta-dehydrogenase 1 region 12
namespace: region
def: "." [DPO:curators, PMID:9525918]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000008773 ! estradiol 17-beta-dehydrogenase 1
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000156
name: estradiol 17-beta-dehydrogenase 1 region 13
namespace: region
def: "." [DPO:curators, PMID:9525918]
comment: The experimental sequence used for PDB ID 1FDV contained a H221L substitution.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000008773 ! estradiol 17-beta-dehydrogenase 1
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000157
name: estradiol 17-beta-dehydrogenase 1 region 14
namespace: region
def: "." [DPO:curators, PMID:9525918]
comment: The experimental sequence used for PDB ID 1FDV contained a H221L substitution.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000008773 ! estradiol 17-beta-dehydrogenase 1
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000050 ! substrate/ligand binding

[Term]
id: DPO:000158
name: estradiol 17-beta-dehydrogenase 1 region 15
namespace: region
def: "." [DPO:curators, PMID:9525918]
comment: The sequence used for PDB ID 1FDW contained a H221Q substitution.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000008773 ! estradiol 17-beta-dehydrogenase 1
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000023 ! disordered region is not essential for protein function
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000159
name: estradiol 17-beta-dehydrogenase 1 region 16
namespace: region
def: "." [DPO:curators, PMID:9525918]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000008773 ! estradiol 17-beta-dehydrogenase 1
relationship: has_subfunction DPO:000023 ! disordered region is not essential for protein function
relationship: has_subfunction DPO:000042 ! protein-lipid interaction

[Term]
id: DPO:000160
name: estradiol 17-beta-dehydrogenase 1 region 17
namespace: region
def: "." [DPO:curators, PMID:9927655]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000008773 ! estradiol 17-beta-dehydrogenase 1
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000161
name: estradiol 17-beta-dehydrogenase 1 region 18
namespace: region
def: "." [DPO:curators, PMID:10625652]
comment: The 3DHE PDB file gives this protein fragment as complexed with Dehydroepiandrosterone. The 1DHT PDB file gives this protein fragment as complexed with Dihydrotestosterone.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000008773 ! estradiol 17-beta-dehydrogenase 1
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000023 ! disordered region is not essential for protein function
relationship: has_subfunction DPO:000050 ! substrate/ligand binding

[Term]
id: DPO:000162
name: estradiol 17-beta-dehydrogenase 1 region 19
namespace: region
def: "." [DPO:curators, PMID:12490543]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000008773 ! estradiol 17-beta-dehydrogenase 1
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000163
name: protein E7 region 1
namespace: region
def: "." [DPO:curators, PMID:8245034]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000164
name: fibronectin-binding protein A region 1
namespace: region
def: "." [DPO:curators, PMID:9398523]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000165
name: flagellin region 1
namespace: region
def: "." [DPO:curators, PMID:2810365]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000166
name: flagellin region 2
namespace: region
def: "." [DPO:curators, PMID:2810365]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000167
name: negative regulator of flagellin synthesis region 1
namespace: region
def: "." [DPO:curators, PMID:9095196]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000168
name: eukaryotic translation initiation factor 4E-binding protein 1 region 1
namespace: region
def: "." [DPO:curators, PMID:9684899]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000006994 ! eukaryotic translation initiation factor 4E-binding protein 1

[Term]
id: DPO:000169
name: glial cell line-derived neurotrophic factor region 1
namespace: region
def: "." [DPO:curators, PMID:9187648, PMID:10545102]
comment: The first identifiable residue in 1AGQ was ASN 115 in chain A, LYS 114 in chain B, GLY 117 in chain C, and GLY 117 in chain D.  This supports claims in the Eigenbrot paper about dependency on the monomer.   The experimental protein consisted of residues 78 - 211 of SwissProt entry Q07731.
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000170
name: glial cell line-derived neurotrophic factor region 2
namespace: region
def: "." [DPO:curators, PMID:10545102]
comment: This sequence is part of a flexible loop that connects the alpha helix region to the second finger region of the protein.
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000171
name: glial cell line-derived neurotrophic factor region 3
namespace: region
def: "." [DPO:curators, PMID:9187648]
is_a: DPO:000006 ! ordered region

[Term]
id: DPO:000172
name: glial cell line-derived neurotrophic factor region 4
namespace: region
def: "." [DPO:curators, PMID:9187648]
is_a: DPO:000006 ! ordered region

[Term]
id: DPO:000173
name: glucocorticoid receptor region 1
namespace: region
def: "." [DPO:curators, PMID:10196139, PMID:7878043, PMID:12902338]
comment: The 58 residue Tau1 core region of the disordered polypeptide from 187-244 retains 60-70% of the activity of the domain. The disordered region is devoid of structure at neutral pH in aqueous solution. The ligand-binding domain becomes notably more structured in the presence of triflouroethanol (TFE). TFE creates a more non-polar environment and favors secondary structure formation. The propensity towards alpha-helicial structure may be an important step in Tau1-mediated gene activation
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000011406 ! glucocorticoid receptor
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000174
name: glucocorticoid receptor region 2
namespace: region
def: "." [DPO:curators, PMID:10196139]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000011406 ! glucocorticoid receptor
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000175
name: glycine N-methyltransferase region 1
namespace: region
def: "." [DPO:curators, PMID:10756111]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000176
name: glycyl-tRNA synthetase region 1
namespace: region
def: "." [DPO:curators, PMID:10064708, PMID:7556056]
comment: The PDB chains 1B76 A and B have the disordered region spanning residues 96-158.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000046 ! protein-tRNA binding

[Term]
id: DPO:000177
name: growth hormone receptor region 1
namespace: region
def: "." [DPO:curators, PMID:9571026]
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000178
name: growth hormone receptor region 2
namespace: region
def: "." [DPO:curators, PMID:9571026]
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000179
name: growth hormone receptor region 3
namespace: region
def: "." [DPO:curators, PMID:9571026]
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000180
name: growth hormone receptor region 4
namespace: region
def: "." [DPO:curators, PMID:9571026]
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000181
name: growth hormone receptor region 5
namespace: region
def: "." [DPO:curators, PMID:9571026, PMID:1549776]
comment: Residues 222-226 had poor electron density and were not modeled in the crystal structure (Clackson, 1998).
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000182
name: growth hormone receptor region 6
namespace: region
def: "." [DPO:curators, PMID:9571026, PMID:1549776]
comment: The binding proteins of the 1:2 (hormone:binding protein) complex are hGHbp I and hGHbp II. De Vos found this region to be disordered in hGHbp I (de Vos 1992).
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000183
name: growth hormone receptor region 7
namespace: region
def: "." [DPO:curators, PMID:8943276]
comment: The N-terminus region of the hGHbp, for both the native 1:2 complex and the mutated 1:1 complex, had missing electron density for the first 31 residues (Sundstrom, 1996).
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000184
name: growth hormone receptor region 8
namespace: region
def: "." [DPO:curators, PMID:8943276]
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000185
name: growth hormone receptor region 9
namespace: region
def: "." [DPO:curators, PMID:8943276]
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000186
name: growth hormone receptor region 10
namespace: region
def: "." [DPO:curators, PMID:8943276]
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000187
name: growth hormone receptor region 11
namespace: region
def: "." [DPO:curators, PMID:9571026]
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000188
name: growth hormone receptor region 12
namespace: region
def: "." [DPO:curators, PMID:9571026]
comment: This region is likely stabilized upon binding of the second receptor to the growth hormone in the 1:2 complex (Clackson, 1998).
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000189
name: growth hormone receptor region 13
namespace: region
def: "." [DPO:curators, PMID:1549776]
comment: The binding proteins of the 1:2 (hormone:binding protein) complex are hGHbp I and hGHbp II. De Vos found this region to be disordered in hGHbp II (de Vos 1992).
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000190
name: growth hormone receptor region 14
namespace: region
def: "." [DPO:curators, PMID:1549776]
comment: The binding proteins of the 1:2 (hormone:binding protein) complex are hGHbp I and hGHbp II. De Vos found this region to be disordered in hGHbp II (de Vos 1992).
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000191
name: growth hormone receptor region 15
namespace: region
def: "." [DPO:curators, PMID:1549776]
comment: In the de Vos reference, (de Vos_Science_255_306-312), they refer to both of the binding proteins of the 1:2 (hormone:binding proteins) complex. They are named hGHbp I and hGHbp II.  De Vos found this region to be disordered in the hGHbp II.
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000192
name: growth hormone receptor region 16
namespace: region
def: "." [DPO:curators, PMID:1549776]
comment: In the de Vos reference, (de Vos_Science_255_306-312), they refer to both of the binding proteins of the 1:2 (hormone:binding proteins) complex. They are named hGHbp I and hGHbp II.  De Vos found this region to be disordered in the hGHbp I.
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000193
name: growth hormone receptor region 17
namespace: region
def: "." [DPO:curators, PMID:1549776]
comment: The binding proteins of the 1:2 (hormone:binding protein) complex are hGHbp I and hGHbp II. De Vos found this region to be disordered in hGHbp I (de Vos 1992).
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000194
name: growth hormone receptor region 18
namespace: region
def: "." [DPO:curators, PMID:1549776]
comment: The binding proteins of the 1:2 (hormone:binding protein) complex are hGHbp I and hGHbp II. De Vos found this region to be disordered in hGHbp I (de Vos 1992).
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000195
name: attachment protein G3P region 1
namespace: region
def: "." [DPO:curators, PMID:10329170, PMID:10756036]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000196
name: guanine nucleotide-binding protein G(i), alpha-1 subunit region 1
namespace: region
def: "." [DPO:curators, PMID:8073283]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000197
name: heat shock factor protein region 1
namespace: region
def: "." [DPO:curators, PMID:8745404]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000198
name: heat shock factor protein region 2
namespace: region
def: "." [DPO:curators, PMID:7849597]
comment: The fragment used for solution structure determination was the DNA-binding domain.(aa194-aa282)
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)

[Term]
id: DPO:000199
name: heat shock factor protein region 3
namespace: region
def: "." [DPO:curators, PMID:7849597]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000040 ! protein-DNA binding

[Term]
id: DPO:000200
name: heat shock factor protein region 4
namespace: region
def: "." [DPO:curators, PMID:8284672]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000040 ! protein-DNA binding

[Term]
id: DPO:000201
name: probable peroxiredoxin region 1
namespace: region
def: "." [DPO:curators, PMID:16214169]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000202
name: probable peroxiredoxin region 2
namespace: region
def: "." [DPO:curators, PMID:16214169]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000203
name: probable peroxiredoxin region 3
namespace: region
def: "." [DPO:curators, PMID:16214169]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000204
name: probable peroxiredoxin region 4
namespace: region
def: "." [DPO:curators, PMID:16214169]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000205
name: probable peroxiredoxin region 5
namespace: region
def: "." [DPO:curators, PMID:16214169]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000206
name: non-histone chromosomal protein HMG-14 region 1
namespace: region
def: "." [DPO:curators, PMID:6273163]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000018 ! acetylation
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000207
name: non-histone chromosomal protein HMG-17 region 1
namespace: region
def: "." [DPO:curators, PMID:565710]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000008640 ! non-histone chromosomal protein HMG-17
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000018 ! acetylation
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000208
name: high mobility group protein HMG-I/HMG-Y region 1
namespace: region
def: "." [DPO:curators, PMID:7559428, PMID:10372360, PMID:11498590, PMID:11593421]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000008628 ! high mobility group protein HMG-I/HMG-Y
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000209
name: high mobility group-T protein region 1
namespace: region
def: "." [DPO:curators, PMID:6273163]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000210
name: non-histone chromosomal protein H6 region 1
namespace: region
def: "." [DPO:curators, PMID:6273163]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000211
name: protein tonB region 1
namespace: region
def: "." [DPO:curators, PMID:15644214]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000024083 ! protein tonB
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000212
name: histone H5 region 1
namespace: region
def: "." [DPO:curators, PMID:2181148]
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000213
name: histone H5 region 2
namespace: region
def: "." [DPO:curators, PMID:2181148]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000214
name: histone H5 region 3
namespace: region
def: "." [DPO:curators, PMID:2181148]
is_a: DPO:000006 ! ordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000052 ! ordered state

[Term]
id: DPO:000215
name: hypoxanthine-guanine phosphoribosyltransferase region 1
namespace: region
def: "." [DPO:curators, PMID:9790669]
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000216
name: hypoxanthine-guanine phosphoribosyltransferase region 2
namespace: region
def: "." [DPO:curators, PMID:9790669]
is_a: DPO:000006 ! ordered region

[Term]
id: DPO:000217
name: lymphoid enhancer-binding factor 1 region 1
namespace: region
def: "." [DPO:curators, PMID:7651541]
is_a: DPO:000008 ! disordered - extended region
relationship: has_subfunction DPO:000024 ! DNA bending
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000218
name: myelin basic protein region 1
namespace: region
def: "." [DPO:curators, PMID:10394626]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000042 ! protein-lipid interaction
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000219
name: protein Nef region 1
namespace: region
def: "." [DPO:curators, PMID:9351809]
comment: This region was disordered according to the PDB files.
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000047 ! regulation of proteolysis in vivo
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000042 ! protein-lipid interaction
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000030 ! fatty acylation (myristolation and palmitoylation)
relationship: has_structural_basis_for_function DPO:000053 ! disordered state
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000220
name: protein Nef region 2
namespace: region
def: "." [DPO:curators, PMID:9351809]
comment: This region was disordered according to the PDB files.
is_a: DPO:000008 ! disordered - extended region
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000221
name: protein Nef region 3
namespace: region
def: "." [DPO:curators, PMID:9351809]
comment: This region was disordered according to the PDB files.
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000222
name: protein Nef region 4
namespace: region
def: "." [DPO:curators, PMID:11406408]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000047 ! regulation of proteolysis in vivo
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000042 ! protein-lipid interaction
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000030 ! fatty acylation (myristolation and palmitoylation)
relationship: has_structural_basis_for_function DPO:000053 ! disordered state
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000223
name: protein Nef region 5
namespace: region
def: "." [DPO:curators, PMID:11406408]
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000224
name: protein Nef region 6
namespace: region
def: "." [DPO:curators, PMID:11406408]
is_a: DPO:000006 ! ordered region

[Term]
id: DPO:000225
name: protein Nef region 7
namespace: region
def: "." [DPO:curators, PMID:11406408]
is_a: DPO:000006 ! ordered region

[Term]
id: DPO:000226
name: myelin transcription factor 1-like protein region 1
namespace: region
def: "." [DPO:curators, PMID:10606515]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000227
name: neurofilament heavy polypeptide region 1
namespace: region
def: "." [DPO:curators, PMID:3220257, PMID:9424114, PMID:9714161]
comment: According to Brown (1997), the disordered region is a portion of the C-terminus. However, the exact numbered amino acids are not documented in the literature.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000011118 ! neurofilament heavy polypeptide

[Term]
id: DPO:000228
name: ornithine decarboxylase region 1
namespace: region
def: "." [DPO:curators, PMID:10563800]
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000229
name: ornithine decarboxylase region 2
namespace: region
def: "." [DPO:curators, PMID:10563800]
comment: PDB 1QU4 contains an A69K substitution
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000230
name: ornithine decarboxylase region 3
namespace: region
def: "." [DPO:curators, PMID:10563800]
comment: PDB 1QU4 contains an A69K substitution
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000231
name: ornithine decarboxylase region 4
namespace: region
def: "." [DPO:curators, PMID:10563800]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000232
name: ornithine decarboxylase region 5
namespace: region
def: "." [DPO:curators, PMID:10985770]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000233
name: ornithine decarboxylase region 6
namespace: region
def: "." [DPO:curators, PMID:10985770]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000234
name: ornithine decarboxylase region 7
namespace: region
def: "." [DPO:curators, PMID:10985770]
comment: PDB entry 1F3T contains an A69K substitution
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000235
name: ornithine decarboxylase region 8
namespace: region
def: "." [DPO:curators, PMID:10985770]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000236
name: SPARC region 1
namespace: region
def: "." [DPO:curators, PMID:3427055]
comment: Two calcium binding domains are known but more may exist.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000015475 ! SPARC
relationship: has_structural_basis_for_function DPO:000063 ! disorder to pre-molten globule transition

[Term]
id: DPO:000237
name: phenylalanyl-tRNA synthetase alpha chain region 1
namespace: region
def: "." [DPO:curators, PMID:9016717, PMID:7664121]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000238
name: phosphatidylinositol-4-phosphate 5-kinase type II beta region 1
namespace: region
def: "." [DPO:curators, PMID:9753329]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000012742 ! phosphatidylinositol-5-phosphate 4-kinase type-2 beta

[Term]
id: DPO:000239
name: phosphatidylinositol-4-phosphate 5-kinase type II beta region 2
namespace: region
def: "." [DPO:curators, PMID:9753329]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000012742 ! phosphatidylinositol-5-phosphate 4-kinase type-2 beta
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000240
name: phosphatidylinositol-4-phosphate 5-kinase type II beta region 3
namespace: region
def: "." [DPO:curators, PMID:9753329]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012742 ! phosphatidylinositol-5-phosphate 4-kinase type-2 beta

[Term]
id: DPO:000241
name: phosphatidylinositol-4-phosphate 5-kinase type II beta region 4
namespace: region
def: "." [DPO:curators, PMID:9753329]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012742 ! phosphatidylinositol-5-phosphate 4-kinase type-2 beta

[Term]
id: DPO:000242
name: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 region 1
namespace: region
def: "." [DPO:curators, PMID:8602259, PMID:8784353]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000243
name: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 region 2
namespace: region
def: "." [DPO:curators, PMID:8784353]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000244
name: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 region 3
namespace: region
def: "." [DPO:curators, PMID:8784353]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000245
name: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 region 4
namespace: region
def: "." [DPO:curators, PMID:8784353]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000246
name: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 region 5
namespace: region
def: "." [DPO:curators, PMID:8602259]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000247
name: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 region 6
namespace: region
def: "." [DPO:curators, PMID:8602259]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000248
name: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 region 7
namespace: region
def: "." [DPO:curators, PMID:8784353]
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000249
name: sperm histone region 1
namespace: region
def: "." [DPO:curators, PMID:2243113, PMID:2738040]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000250
name: prothymosin alpha region 1
namespace: region
def: "." [DPO:curators, PMID:7548085]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000251
name: modification methylase PvuII region 1
namespace: region
def: "." [DPO:curators, PMID:9207015]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000035 ! methylation

[Term]
id: DPO:000252
name: modification methylase PvuII region 2
namespace: region
def: "." [DPO:curators, PMID:9207015]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_subfunction DPO:000035 ! methylation
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000253
name: replication protein A 70 kDa DNA-binding subunit region 1
namespace: region
def: "." [DPO:curators, PMID:10526407]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000014170 ! replication protein A 70 kDa DNA-binding subunit

[Term]
id: DPO:000254
name: retinoic acid receptor RXR-alpha region 1
namespace: region
def: "." [DPO:curators, PMID:9698548, PMID:9826495]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000014372 ! retinoic acid receptor RXR-alpha
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000040 ! protein-DNA binding

[Term]
id: DPO:000255
name: retinoic acid receptor RXR-alpha region 2
namespace: region
def: "." [DPO:curators, PMID:9698548, PMID:9826495]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000014372 ! retinoic acid receptor RXR-alpha
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000256
name: retinoic acid receptor RXR-alpha region 3
namespace: region
def: "." [DPO:curators, PMID:9698548, PMID:9826495]
comment: This region contains the D-box as well as the second zinc binding domain and lies between the first and second helices. 
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000014372 ! retinoic acid receptor RXR-alpha
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000257
name: retinoic acid receptor RXR-alpha region 4
namespace: region
def: "." [DPO:curators, PMID:9698548, PMID:9826495]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000014372 ! retinoic acid receptor RXR-alpha
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000258
name: retinoic acid receptor RXR-alpha region 5
namespace: region
def: "." [DPO:curators, PMID:9698548, PMID:9826495]
comment: The C-terminal helix undergoes an order to disorder transition upon binding to DNA. The unwinding of the helix most likely facilitates homodimer formation by maximizing interactions between the two DNA-bound RXR proteins.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000014372 ! retinoic acid receptor RXR-alpha
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000059 ! order to disorder transition

[Term]
id: DPO:000259
name: regulator of G-protein signaling 4 region 1
namespace: region
def: "." [DPO:curators, PMID:9108480]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000260
name: regulator of G-protein signaling 4 region 2
namespace: region
def: "." [DPO:curators, PMID:9108480]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000261
name: capsid protein region 1
namespace: region
def: "." [DPO:curators, PMID:6854633]
comment: This region is disordered in all three subunits.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000262
name: capsid protein region 2
namespace: region
def: "." [DPO:curators, PMID:6854633]
comment: This region is disordered in both the A and B subunits.
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000263
name: capsid protein region 3
namespace: region
def: "." [DPO:curators, PMID:6854633]
comment: This region is disordered in both the A and B subunits.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000264
name: capsid protein region 4
namespace: region
def: "." [DPO:curators, PMID:6854633, PMID:6401119]
comment: This region corresponds to the C subunit only. This region is part of the flexible arm that helps to determine binding specificity.  
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000265
name: capsid protein region 5
namespace: region
def: "." [DPO:curators, PMID:6854633, PMID:6401119]
comment: This region corresponds to the A subunit only.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000266
name: capsid protein region 6
namespace: region
def: "." [DPO:curators, PMID:6854633, PMID:6401119]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000267
name: capsid protein region 7
namespace: region
def: "." [DPO:curators, PMID:6854633, PMID:3681993]
comment: This section is only ordered in the C subunit, and is important in stabilizing the capsid.
is_a: DPO:000006 ! ordered region
relationship: has_structural_basis_for_function DPO:000052 ! ordered state

[Term]
id: DPO:000268
name: capsid protein region 8
namespace: region
def: "." [DPO:curators, PMID:6854633]
comment: This region is only ordered in the C subunit.  
is_a: DPO:000006 ! ordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000052 ! ordered state

[Term]
id: DPO:000269
name: capsid protein region 9
namespace: region
def: "." [DPO:curators, PMID:6854633]
comment: This region is only ordered in the C subunit.
is_a: DPO:000006 ! ordered region
relationship: has_structural_basis_for_function DPO:000052 ! ordered state

[Term]
id: DPO:000270
name: serine-aspartate repeat-containing protein D region 1
namespace: region
def: "." [DPO:curators, PMID:9813018]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000271
name: structural polyprotein region 1
namespace: region
def: "." [DPO:curators, PMID:1944569]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000272
name: small heat shock protein HSP16.5 region 1
namespace: region
def: "." [DPO:curators, PMID:9707123]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000273
name: synaptosomal-associated protein 25 region 1
namespace: region
def: "." [DPO:curators, PMID:9671503]
comment: The sequence has 98% similarity to that of chicken and human SNAP-25 but there is no  100% match to any organism when Blasted.
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000274
name: vesicle-associated membrane protein 2 region 1
namespace: region
def: "." [DPO:curators, PMID:9346956]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000017249 ! vesicle-associated membrane protein 2
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000275
name: vesicle-associated membrane protein 2 region 2
namespace: region
def: "." [DPO:curators, PMID:10481273]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000017249 ! vesicle-associated membrane protein 2
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000276
name: vesicle-associated membrane protein 2 region 3
namespace: region
def: "." [DPO:curators, PMID:9852083]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000017249 ! vesicle-associated membrane protein 2
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000277
name: alpha-synuclein region 1
namespace: region
def: "." [DPO:curators, PMID:8901511, PMID:11312271, PMID:11590151, PMID:11286556]
comment: This region is composed of an N-terminal membrane anchoring region (residues 1 - 60), the central hydrophobic/amyloidogenic NAC region (residues 61-95), and a C-terminal acidic region (residues 96-140) that is inhibitory to amyloid formation.  Amyloid formation may be the result of both phosphorylation of Ser129 and metal binding in the C-terminal region.  When this occurs, residues 36 - 99 take on a cross-beta sheet structure characteristic of most amyloids, while the N- and C-termini remain statically and dynamically disordered, respectively.
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_subfunction DPO:000038 ! polymerization
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000278
name: homeobox protein Nkx-2.1 region 1
namespace: region
def: "." [DPO:curators, PMID:9425125]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000279
name: homeobox protein Nkx-2.1 region 2
namespace: region
def: "." [DPO:curators, PMID:9425125]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000280
name: homeobox protein Nkx-2.1 region 3
namespace: region
def: "." [DPO:curators, PMID:9425125]
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000281
name: estrogen receptor [Isoform long] region 1
namespace: region
def: "." [DPO:curators, PMID:11595744]
comment: The fragment used consisted of residues 1-184.
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000282
name: estrogen receptor [Isoform long] region 2
namespace: region
def: "." [DPO:curators, PMID:16100953]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000283
name: estrogen receptor [Isoform long] region 3
namespace: region
def: "." [DPO:curators, PMID:16100953]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000284
name: DNA topoisomerase 1 region 1
namespace: region
def: "." [DPO:curators, PMID:8567649, PMID:10380229, PMID:8631793]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000036 ! nuclear localization
relationship: has_subfunction DPO:000021 ! autoregulatory
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000023 ! disordered region is not essential for protein function
relationship: has_structural_basis_for_function DPO:000052 ! ordered state

[Term]
id: DPO:000285
name: DNA topoisomerase 1 region 2
namespace: region
def: "." [DPO:curators, PMID:8567649, PMID:9611241, PMID:10380229, PMID:8631793, PMID:8631794]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000021 ! autoregulatory
relationship: has_subfunction DPO:000023 ! disordered region is not essential for protein function
relationship: has_subfunction DPO:000036 ! nuclear localization
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000286
name: DNA topoisomerase 1 region 3
namespace: region
def: "." [DPO:curators, PMID:8567649, PMID:14654701, PMID:14741206, PMID:11283003, PMID:9488644]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1

[Term]
id: DPO:000287
name: DNA topoisomerase 1 region 4
namespace: region
def: "." [DPO:curators, PMID:8567649, PMID:14654701, PMID:14741206, PMID:11283003, PMID:9488652]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1

[Term]
id: DPO:000288
name: DNA topoisomerase 1 region 5
namespace: region
def: "." [DPO:curators, PMID:9488652]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1

[Term]
id: DPO:000289
name: DNA topoisomerase 1 region 6
namespace: region
def: "." [DPO:curators, PMID:9488644]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1

[Term]
id: DPO:000290
name: DNA topoisomerase 1 region 7
namespace: region
def: "." [DPO:curators, PMID:10497031, PMID:9488652]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1

[Term]
id: DPO:000291
name: DNA topoisomerase 1 region 8
namespace: region
def: "." [DPO:curators, PMID:9488652]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1

[Term]
id: DPO:000292
name: DNA topoisomerase 1 region 9
namespace: region
def: "." [DPO:curators, PMID:9488644]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1

[Term]
id: DPO:000293
name: DNA topoisomerase 1 region 10
namespace: region
def: "." [DPO:curators, PMID:9488644]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1

[Term]
id: DPO:000294
name: DNA topoisomerase 1 region 11
namespace: region
def: "." [DPO:curators, PMID:9488652]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1

[Term]
id: DPO:000295
name: DNA topoisomerase 1 region 12
namespace: region
def: "." [DPO:curators, PMID:9488644]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1

[Term]
id: DPO:000296
name: DNA topoisomerase 1 region 13
namespace: region
def: "." [DPO:curators, PMID:10497031]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1

[Term]
id: DPO:000297
name: DNA topoisomerase 1 region 14
namespace: region
def: "." [DPO:curators, PMID:10497031]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1

[Term]
id: DPO:000298
name: DNA topoisomerase 1 region 15
namespace: region
def: "." [DPO:curators, PMID:10497031]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1

[Term]
id: DPO:000299
name: DNA topoisomerase 1 region 16
namespace: region
def: "." [DPO:curators, PMID:10497031]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1

[Term]
id: DPO:000300
name: DNA topoisomerase 1 region 17
namespace: region
def: "." [DPO:curators, PMID:10497031]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1

[Term]
id: DPO:000301
name: DNA topoisomerase 1 region 18
namespace: region
def: "." [DPO:curators, PMID:10497031]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1

[Term]
id: DPO:000302
name: DNA topoisomerase 1 region 19
namespace: region
def: "." [DPO:curators, PMID:10497031]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1

[Term]
id: DPO:000303
name: DNA topoisomerase 1 region 20
namespace: region
def: "." [DPO:curators, PMID:10497031]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1

[Term]
id: DPO:000304
name: DNA topoisomerase 1 region 21
namespace: region
def: "." [DPO:curators, PMID:10497031]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1

[Term]
id: DPO:000305
name: DNA topoisomerase 1 region 22
namespace: region
def: "." [DPO:curators, PMID:10497031]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1

[Term]
id: DPO:000306
name: DNA topoisomerase 1 region 23
namespace: region
def: "." [DPO:curators, PMID:10497031]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1

[Term]
id: DPO:000307
name: DNA topoisomerase 1 region 24
namespace: region
def: "." [DPO:curators, PMID:10497031]
comment: The loop leading up to His632 (residues 626 - 632) is disordered in four out of five structures A-E. His632 may stabilize the transition state of the scissile phosphorus atom that was exposed through nucleophilic attack by an activated C4-oxygen atom of Tyr723.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016542 ! DNA topoisomerase 1

[Term]
id: DPO:000308
name: DNA topoisomerase 2 region 1
namespace: region
def: "." [DPO:curators, PMID:8538787]
comment: DP00076 - The experimental fragment was composed of residues 410 - 1202.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000309
name: DNA topoisomerase 2 region 2
namespace: region
def: "." [DPO:curators, PMID:8538787]
comment: DP00076 - The experimental fragment was composed of residues 410 - 1202.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000310
name: DNA topoisomerase 2 region 3
namespace: region
def: "." [DPO:curators, PMID:8538787]
comment: DP00076 - The experimental fragment was composed of residues 410 - 1202.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000311
name: DNA topoisomerase 2 region 4
namespace: region
def: "." [DPO:curators, PMID:8538787]
comment: DP00076 - The experimental fragment was composed of residues 410 - 1202.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000312
name: DNA topoisomerase 2 region 5
namespace: region
def: "." [DPO:curators, PMID:8538787]
comment: DP00076 - The experimental fragment was composed of residues 410 - 1202.
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000313
name: DNA topoisomerase 2 region 6
namespace: region
def: "." [DPO:curators, PMID:8538787]
comment: DP00076 - The experimental fragment was composed of residues 410 - 1202.
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000314
name: DNA topoisomerase 2 region 7
namespace: region
def: "." [DPO:curators, PMID:8538787]
comment: DP00076 - The experimental fragment was composed of residues 410 - 1202.
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000315
name: DNA topoisomerase 2 region 8
namespace: region
def: "." [DPO:curators, PMID:8538787]
comment: DP00076 - The experimental fragment was composed of residues 410 - 1202.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000316
name: DNA topoisomerase 2 region 9
namespace: region
def: "." [DPO:curators, PMID:8538787]
comment: DP00076 - The experimental fragment was composed of residues 410 - 1202.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000317
name: DNA topoisomerase 2 region 10
namespace: region
def: "." [DPO:curators, PMID:8538787]
comment: DP00076 - The experimental fragment was composed of residues 410 - 1202.
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000318
name: DNA topoisomerase 2 region 11
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000319
name: regulatory protein ADR1 region 1
namespace: region
def: "." [DPO:curators, PMID:9642072, PMID:3515197]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000320
name: regulatory protein ADR1 region 2
namespace: region
def: "." [DPO:curators, PMID:9642072, PMID:3515197]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000321
name: proto-oncogene protein c-fos region 1
namespace: region
def: "." [DPO:curators, PMID:10704222, PMID:11749217]
comment: Helical or beta-sheet structure is not induced in Fos-AD by changes in pH or ionic strength. Chemical shift data indicated that Fos-AD lacked the stable secondary or tertiary structure normally found with globular proteins. Fos-AD has a Stokes radius that is twice that of a compact globular protein (35 compared to 17) indicating that Fos-AD is unfolded, and sedimentation equilibrium indicated that Fos-AD is monomeric. Negative amide NOEs indicate that the main chain of Fos-AD is highly flexible and exists in a motional system expected for an unfolded protein.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000007597 ! proto-oncogene protein c-fos
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000021 ! autoregulatory
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000322
name: estrogen receptor beta [Isoform 1 (Beta-1)] region 1
namespace: region
def: "." [DPO:curators, PMID:11595744]
comment: The fragment consisted of residues 1-103.
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000050 ! substrate/ligand binding

[Term]
id: DPO:000323
name: cyclic AMP-responsive element-binding protein 1 region 1
namespace: region
def: "." [DPO:curators, PMID:9413984]
comment: Upon binding to the KIX domain of the CREB binding protein this region remains disordered.
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000324
name: cyclic AMP-responsive element-binding protein 1 region 2
namespace: region
def: "." [DPO:curators, PMID:9413984, PMID:9688563]
comment: Upon binding to the KIX domain of the CREB binding protein this region forms two alpha helices, alphaA and alphaB. The two fold into mutually perpendicular helices that run from Asp-120 to Ser-129 and Pro-132 to Asp-144, respectively. 
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000325
name: cyclic AMP-responsive element-binding protein 1 region 3
namespace: region
def: "." [DPO:curators, PMID:9413984]
comment: Upon binding to the KIX domain of the CREB binding protein this region remains unstructured.
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000326
name: transcription initiation factor TFIID subunit 1 region 1
namespace: region
def: "." [DPO:curators, PMID:9741622]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000327
name: eukaryotic initiation factor 4F subunit p150 region 1
namespace: region
def: "." [DPO:curators, PMID:10409688]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000328
name: general control protein GCN4 region 1
namespace: region
def: "." [DPO:curators, PMID:2145515]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000329
name: protein max [Isoform 2] region 1
namespace: region
def: "." [DPO:curators, PMID:9399572, PMID:16171389]
comment: The experimental sequence consisted of the first 110 residues of Max.
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000330
name: protein max [Isoform 2] region 2
namespace: region
def: "." [DPO:curators, PMID:16171389]
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000331
name: transcription factor p65 region 1
namespace: region
def: "." [DPO:curators, PMID:1935902, PMID:7929265]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000013875 ! transcription factor p65
relationship: has_function DPO:000014 ! modification site
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000021 ! autoregulatory
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000332
name: transcription factor p65 region 2
namespace: region
def: "." [DPO:curators, PMID:1935902, PMID:7929265]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000013875 ! transcription factor p65
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000333
name: transcription factor p65 region 3
namespace: region
def: "." [DPO:curators, PMID:7929265]
comment: NMR analysis of a protein corresponding to the C-terminal 123 amino acids showed a random coil conformation, which indicates that the entire transactivating C-terminus is unstructured. 
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000013875 ! transcription factor p65
relationship: has_function DPO:000014 ! modification site
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000334
name: cellular tumor antigen p53 region 1
namespace: region
def: "." [DPO:curators, PMID:7559631]
comment: This disordered region was discovered in an engineered fragment containing residues 1-73.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000003035 ! cellular tumor antigen p53
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000335
name: cellular tumor antigen p53 region 2
namespace: region
def: "." [DPO:curators, PMID:8875929]
comment: This disordered region was discovered in an engineered fragment containing residues 15-29.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000003035 ! cellular tumor antigen p53
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000336
name: cellular tumor antigen p53 region 3
namespace: region
def: "." [DPO:curators, PMID:8875929]
comment: The protein studied was an engineered fragment containing residues 15-29.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000003035 ! cellular tumor antigen p53
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000337
name: cellular tumor antigen p53 region 4
namespace: region
def: "." [DPO:curators, PMID:12351827, PMID:12110597]
comment: The disordered region characterized was studied in an engineered fragment containing residues 95-292.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000003035 ! cellular tumor antigen p53

[Term]
id: DPO:000338
name: cellular tumor antigen p53 region 5
namespace: region
def: "." [DPO:curators, PMID:12351827, PMID:12110597]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000003035 ! cellular tumor antigen p53

[Term]
id: DPO:000339
name: cellular tumor antigen p53 region 6
namespace: region
def: "." [DPO:curators, PMID:12351827, PMID:12110597]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000003035 ! cellular tumor antigen p53

[Term]
id: DPO:000340
name: cellular tumor antigen p53 region 7
namespace: region
def: "." [DPO:curators, PMID:14534297]
comment: The disordered region characterized was from an engineered fragment containing residues 94-312 and mutations at M133L, V203A, N239Y, N268D.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000003035 ! cellular tumor antigen p53

[Term]
id: DPO:000341
name: cellular tumor antigen p53 region 8
namespace: region
def: "." [DPO:curators]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000003035 ! cellular tumor antigen p53
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000342
name: cellular tumor antigen p53 region 9
namespace: region
def: "." [DPO:curators]
comment: This disordered region was located in an engineered fragment containing residues 319-360.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000003035 ! cellular tumor antigen p53
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000343
name: tegument protein VP16 region 1
namespace: region
def: "." [DPO:curators, PMID:10398682]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000344
name: tegument protein VP16 region 2
namespace: region
def: "." [DPO:curators, PMID:10398682]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000345
name: ubiquinol oxidase subunit 1 region 1
namespace: region
def: "." [DPO:curators, PMID:11017202, PMID:2162835]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022369 ! ubiquinol oxidase subunit 1

[Term]
id: DPO:000346
name: ubiquinol oxidase subunit 1 region 2
namespace: region
def: "." [DPO:curators, PMID:11017202, PMID:2162835]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022369 ! ubiquinol oxidase subunit 1

[Term]
id: DPO:000347
name: ubiquinol oxidase subunit 1 region 3
namespace: region
def: "." [DPO:curators, PMID:11017202, PMID:2162835]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022369 ! ubiquinol oxidase subunit 1

[Term]
id: DPO:000348
name: ubiquinol oxidase subunit 1 region 4
namespace: region
def: "." [DPO:curators, PMID:11017202, PMID:2162835]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022369 ! ubiquinol oxidase subunit 1

[Term]
id: DPO:000349
name: ubiquinol oxidase subunit 1 region 5
namespace: region
def: "." [DPO:curators, PMID:11017202, PMID:2162835]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022369 ! ubiquinol oxidase subunit 1

[Term]
id: DPO:000350
name: ubiquinol oxidase subunit 2 region 1
namespace: region
def: "." [DPO:curators, PMID:11017202]
comment: This region is located in the periplasmic space. Abramson et al. could not assign a sequence for residues 1-36 or 113-124. However the PDB file locates electron density for residues 27-283.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022368 ! ubiquinol oxidase subunit 2

[Term]
id: DPO:000351
name: ubiquinol oxidase subunit 2 region 2
namespace: region
def: "." [DPO:curators, PMID:11017202]
comment: This region is located in the periplasmic space.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022368 ! ubiquinol oxidase subunit 2

[Term]
id: DPO:000352
name: ubiquinol oxidase subunit 2 region 3
namespace: region
def: "." [DPO:curators, PMID:1324168, PMID:8433374, PMID:8618822]
comment: This region is located in the periplasmic space.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022368 ! ubiquinol oxidase subunit 2

[Term]
id: DPO:000353
name: ubiquinol oxidase subunit 2 region 4
namespace: region
def: "." [DPO:curators, PMID:1324168, PMID:8433374, PMID:8618822]
comment: This region is located in the periplasmic space.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022368 ! ubiquinol oxidase subunit 2

[Term]
id: DPO:000354
name: voltage-gated potassium channel subunit beta-1 [Isoform KvB1.1] region 1
namespace: region
def: "." [DPO:curators, PMID:10585425]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000355
name: DNA repair protein complementing XP-A cells homolog region 1
namespace: region
def: "." [DPO:curators, PMID:11344324]
comment: The results from the laboratory experiments were compared to PONDR predictions and found to be identical.  
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000356
name: DNA repair protein complementing XP-A cells homolog region 2
namespace: region
def: "." [DPO:curators, PMID:11344324]
comment: The results from the laboratory experiments were compared to PONDR predictions and found to be identical.  
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000357
name: calcineurin subunit B type 1 region 1
namespace: region
def: "." [DPO:curators, PMID:8524402, PMID:12357034, PMID:8524402]
comment: Mass spectrometry combined with enzymatic digestion showed that the N-terminal residues were  sensitive to proteolysis. (Jin and Harrison, 2002)
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000013150 ! calcineurin subunit B type 1

[Term]
id: DPO:000358
name: calcineurin subunit B type 1 region 2
namespace: region
def: "." [DPO:curators, PMID:8524402, PMID:12357034]
comment: The disordered region from 374-468 includes the CaM-binding domain predicted to lie between residues 390-414.  As in the crystal structure of native CaN, the C-terminal portion of CaNA is disordered beyond the CaNB-binding helix (343-373), and electron density for the CaM-binding domain of CaNA is not visible. (Kissinger CR, et al.)  Mass spectrometry combined with enzymatic digestion showed that the calmodulin-binding region was removed by trypsin, indicating that this disordered region is sensitive to proteolysis. Calmodulin binds to this disordered region between the CnB-binding site and the autoinhibitory helix, and this segment takes on an alpha-helical conformation to pull the AI helix away from the catalytic site in order to activate the phosphatase activity.  (Jin and Harrison) Calmodulin is a protein that wraps around a target helix in calcineurin upon binding.  The ~20-residue target helix is located within a 95-residue disordered region that is not observed in crystal structures.  The disorder allows the target helix to separate from the rest of the protein, thus permitting access for binding.  For the calmodulin/target helix interaction, it is unknown whether the other ~75 disordered residues become ordered upon binding, but it is thought that this region takes on an alpha-helical conformation when calmodulin binds (Jin and Harrison).  The function of the disordered region is to make the helix accessible for calmodulin binding, and this region of disorder is essential to the regulation of calcineurin by calcium/calmodulin.  Binding of calcium/calcineurin activates calcineurin's serine/threonine phosphatase activity.  (Dunker et al., 2001)
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000013150 ! calcineurin subunit B type 1
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000021 ! autoregulatory
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000359
name: calcineurin subunit B type 1 region 3
namespace: region
def: "." [DPO:curators, PMID:8524402]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000013150 ! calcineurin subunit B type 1
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000021 ! autoregulatory
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000360
name: calcineurin subunit B type 1 region 4
namespace: region
def: "." [DPO:curators, PMID:8524402]
comment: As in the crystal structure of native CaN, the C-terminal portion of CaNA is disordered beyond the CaNB-binding helix (343-373), which indicates that the autoinhibitory domain is disordered. However, this disordered region is present for PDB 1AUI. Unlike the native CaN crystal structure, the AI segment of CaN is not seen in the crystal structure of the FKBP12-FK506-CaN complex. This might indicate that the autoinhibitory complex is ordered when CaNA is in a complex with CaNB, but other evidence suggests that when the AI domain is either not in contact with the catalytic domain (as is the case with immunosuppressants) or when CaNA exists as a monomer, the AI domain may not be structured.  Calmodulin binds to the disordered region between the CnB-binding site and the autoinhibitory helix, and this segment takes on an alpha-helical conformation to pull the AI helix away from the catalytic site in order to activate the phosphatase activity according to Jin and Harrison.  When this occurs, the structure of the AI helix may change as well, leading to disorder.  Further evidence needs to be found in order to indicate the state of the AI domain.  For now, the AI domain will be considered disordered based on the statement made by Kissinger above and the information provided by Jin and Harrison in regards to proteolytic sensitivity.  The autoinhibitory domain lies over the substrate-binding cleft in the catalytic domain and consists of two short alpha-helical regions plus five residues in an extended conformation.  The helical regions restrict interaction with the substrate-binding cleft when the AI segment contacts the cleft. (Kissinger CR, et al.)  Mass spectrometry combined with enzymatic digestion showed that the autoinhibitory helix was removed by trypsin, indicating that this disordered region is sensitive to proteolysis. (Jin and Harrison, 2002) 
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000013150 ! calcineurin subunit B type 1
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000021 ! autoregulatory
relationship: has_structural_basis_for_function DPO:000059 ! order to disorder transition
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000361
name: calcineurin subunit B type 1 region 5
namespace: region
def: "." [DPO:curators, PMID:8524402]
comment: CaNA residues 487 - 521 are not visible in the electron density map of the crystal structure and are disordered.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000013150 ! calcineurin subunit B type 1

[Term]
id: DPO:000362
name: calcineurin subunit B type 1 region 6
namespace: region
def: "." [DPO:curators, PMID:8524402]
is_a: DPO:000006 ! ordered region
relationship: part_of PRO:000013150 ! calcineurin subunit B type 1

[Term]
id: DPO:000363
name: tyrosine 3-monooxygenase region 1
namespace: region
def: "." [DPO:curators, PMID:8104613]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000364
name: tyrosyl-tRNA synthetase region 1
namespace: region
def: "." [DPO:curators, PMID:2504923, PMID:12005430]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000050 ! substrate/ligand binding

[Term]
id: DPO:000365
name: lipoate-protein ligase A subunit 1 region 1
namespace: region
def: "." [DPO:curators, PMID:16384580]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000050 ! substrate/ligand binding

[Term]
id: DPO:000366
name: histone H1.0 region 1
namespace: region
def: "." [DPO:curators, PMID:11584004]
comment: The fragment used consisted of residues 1-20.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000008405 ! histone H1.0
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000367
name: histone H1.0 region 2
namespace: region
def: "." [DPO:curators, PMID:11584004]
comment: The fragment used consisted of residues 8-30.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000008405 ! histone H1.0
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000368
name: histone H1.0 region 3
namespace: region
def: "." [DPO:curators, PMID:16006555]
comment: The fragment used consisted of residues 96-193.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000008405 ! histone H1.0
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000369
name: histone H1.0 region 4
namespace: region
def: "." [DPO:curators, PMID:10794405, PMID:11413144]
comment: The fragment used consisted of residues 99-121.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000008405 ! histone H1.0
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000370
name: collagen adhesin region 1
namespace: region
def: "." [DPO:curators, PMID:9334749, PMID:8218209]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000371
name: glycine amidinotransferase, mitochondrial region 1
namespace: region
def: "." [DPO:curators, PMID:9218780, PMID:9165070]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000007865 ! glycine amidinotransferase, mitochondrial

[Term]
id: DPO:000372
name: ATP-dependent hsl protease ATP-binding subunit hslU region 1
namespace: region
def: "." [DPO:curators, PMID:10693812]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022934 ! ATP-dependent hsl protease ATP-binding subunit hslU

[Term]
id: DPO:000373
name: **Gag polyprotein** region 2
namespace: region
def: "." [DPO:curators, PMID:16234236]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000374
name: **Gag polyprotein** region 3
namespace: region
def: "." [DPO:curators, PMID:16234236]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000375
name: myosin-11 region 1
namespace: region
def: "." [DPO:curators, PMID:9741621]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000376
name: myosin-11 region 2
namespace: region
def: "." [DPO:curators, PMID:9741621]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000377
name: myosin-11 region 3
namespace: region
def: "." [DPO:curators, PMID:9147986]
comment: The sequence information for this region came from Rovner et. al. (1997).  It is a deviation from the Yanagisawa et. al sequence.  This region is part of a 7 amino acid insert that helps to differentiate between fast and slow smooth muscle.  The insert increases the proteins enzymatic capabilities, as well as its ability to bind and move actin filaments.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000378
name: myosin-11 region 4
namespace: region
def: "." [DPO:curators, PMID:9741621]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000379
name: myosin-11 region 5
namespace: region
def: "." [DPO:curators, PMID:9741621]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000380
name: myosin-11 region 6
namespace: region
def: "." [DPO:curators, PMID:9741621]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000381
name: myosin-11 region 7
namespace: region
def: "." [DPO:curators, PMID:9741621]
comment: The PDB file 1BR2 shows the disordered region ending at amino acid PRO-548.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000382
name: myosin-11 region 8
namespace: region
def: "." [DPO:curators, PMID:9741621]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000383
name: myosin-11 region 9
namespace: region
def: "." [DPO:curators, PMID:9741621]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000384
name: myosin-11 region 10
namespace: region
def: "." [DPO:curators, PMID:9741621]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000385
name: protein grpE region 1
namespace: region
def: "." [DPO:curators, PMID:9103205]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022840 ! protein grpE

[Term]
id: DPO:000386
name: transcription initiation factor IIA large subunit region 1
namespace: region
def: "." [DPO:curators, PMID:8610010]
comment: The fragment used for structure determination consisted of the C-terminal 76 residues.(aa210-aa286)
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000387
name: diol dehydrase beta subunit region 1
namespace: region
def: "." [DPO:curators, PMID:10467140]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000388
name: diol dehydrase gamma subunit region 1
namespace: region
def: "." [DPO:curators, PMID:10467140]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000389
name: periplasmic [Fe] hydrogenase large subunit region 1
namespace: region
def: "." [DPO:curators, PMID:10368269]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000390
name: carbonic anhydrase region 1
namespace: region
def: "." [DPO:curators, PMID:10924115]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000391
name: protein C-ets-1 region 1
namespace: region
def: "." [DPO:curators, PMID:9770451]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000007221 ! protein C-ets-1

[Term]
id: DPO:000392
name: protein C-ets-1 region 2
namespace: region
def: "." [DPO:curators, PMID:15994560]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000007221 ! protein C-ets-1
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_subfunction DPO:000021 ! autoregulatory
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000393
name: desiccation-related protein clone PCC6-19 region 1
namespace: region
def: "." [DPO:curators, PMID:9067253]
is_a: DPO:000010 ! disordered - molten globule region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000058 ! molten globule to order transition

[Term]
id: DPO:000394
name: synaptobrevin homolog 1 region 1
namespace: region
def: "." [DPO:curators, PMID:9326367]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000395
name: tubulin beta-4 chain region 1
namespace: region
def: "." [DPO:curators, PMID:10211825]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000016820 ! tubulin beta-4 chain

[Term]
id: DPO:000396
name: osteocalcin region 1
namespace: region
def: "." [DPO:curators, PMID:8101026, PMID:8218200]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000397
name: protein transport protein Sec61 subunit gamma region 1
namespace: region
def: "." [DPO:curators, PMID:8942632]
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000398
name: protein transport protein Sec61 subunit gamma region 2
namespace: region
def: "." [DPO:curators, PMID:8942632]
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000399
name: protein transport protein Sec61 subunit gamma region 3
namespace: region
def: "." [DPO:curators, PMID:8942632]
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000400
name: protein transport protein Sec61 subunit gamma region 4
namespace: region
def: "." [DPO:curators, PMID:8942632]
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000401
name: chromogranin-A region 1
namespace: region
def: "." [DPO:curators, PMID:3473966, PMID:8243650]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000402
name: basic salivary proline-rich protein 4 region 1
namespace: region
def: "." [DPO:curators, PMID:4093242]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000013175 ! basic salivary proline-rich protein 4

[Term]
id: DPO:000403
name: caldesmon region 1
namespace: region
def: "." [DPO:curators, PMID:2803315, PMID:14635127, PMID:11996092]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000057 ! pre-molten globule to order transition

[Term]
id: DPO:000404
name: protein L precursor region 1
namespace: region
def: "." [DPO:curators]
is_a: DPO:000008 ! disordered - extended region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000405
name: protein L precursor region 2
namespace: region
def: "." [DPO:curators, PMID:9007989]
is_a: DPO:000008 ! disordered - extended region
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000406
name: protein L precursor region 3
namespace: region
def: "." [DPO:curators, PMID:9007989]
is_a: DPO:000008 ! disordered - extended region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000407
name: protein L precursor region 4
namespace: region
def: "." [DPO:curators, PMID:9007989]
is_a: DPO:000008 ! disordered - extended region
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000408
name: protein L precursor region 5
namespace: region
def: "." [DPO:curators, PMID:9007989]
is_a: DPO:000008 ! disordered - extended region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000409
name: protein L precursor region 6
namespace: region
def: "." [DPO:curators, PMID:9007989]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000410
name: microtubule-associated protein 2 region 1
namespace: region
def: "." [DPO:curators, PMID:15751971]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000411
name: T-cell surface glycoprotein CD4 region 1
namespace: region
def: "." [DPO:curators, PMID:9622505]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000001004 ! CD4
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000412
name: secretogranin-1 region 1
namespace: region
def: "." [DPO:curators, PMID:9136897]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000413
name: somatoliberin region 1
namespace: region
def: "." [DPO:curators, PMID:9375414]
comment: U-90699F is an analog of the bovine growth hormone releasing factor.  It is a fragment that contains the following substitutions:  Ile32, Ser38, Ala45, Leu57, and Ser58.  It also has a C-terminal tag of Hse-NH-ethyl x Ch3COOH.  
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000414
name: microtubule-associated protein tau [Isoform Tau-F] region 1
namespace: region
def: "." [DPO:curators, PMID:14769047, PMID:2484340, PMID:15147841, PMID:7929085]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000415
name: microtubule-associated protein tau [Isoform Tau-F] region 2
namespace: region
def: "." [DPO:curators, PMID:2484340, PMID:15147841, PMID:7929085]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000416
name: microtubule-associated protein tau [Isoform Tau-F] region 3
namespace: region
def: "." [DPO:curators, PMID:14769047, PMID:2484340, PMID:7929085]
comment: This the microtubule binding domain.
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000417
name: microtubule-associated protein tau [Isoform Tau-F] region 4
namespace: region
def: "." [DPO:curators, PMID:2484340, PMID:15147841, PMID:7929085]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000418
name: microtubule-associated protein tau [Isoform Tau-F] region 5
namespace: region
def: "." [DPO:curators, PMID:14769047, PMID:2484340, PMID:7929085]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000419
name: microtubule-associated protein tau [Isoform Tau-F] region 6
namespace: region
def: "." [DPO:curators, PMID:15654759]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000420
name: fibronectin binding protein region 1
namespace: region
def: "." [DPO:curators, PMID:8576127]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000421
name: protein transport protein SEC9 region 1
namespace: region
def: "." [DPO:curators, PMID:10048921]
comment: Sec9 is completely disordered in isolation, but acquires some structure when forming a complex with Sso1.
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000422
name: protein transport protein SEC9 region 2
namespace: region
def: "." [DPO:curators, PMID:9326367]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000423
name: transcription factor p65 region 1
namespace: region
def: "." [DPO:curators, PMID:12686541]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000013875 ! transcription factor p65

[Term]
id: DPO:000424
name: transcription factor p65 region 2
namespace: region
def: "." [DPO:curators, PMID:12686541]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000013875 ! transcription factor p65

[Term]
id: DPO:000425
name: transcription factor p65 region 3
namespace: region
def: "." [DPO:curators, PMID:9384558]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000013875 ! transcription factor p65
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000036 ! nuclear localization

[Term]
id: DPO:000426
name: small proline-rich protein 2E region 1
namespace: region
def: "." [DPO:curators, PMID:3133554, PMID:9722562]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000015577 ! small proline-rich protein 2E
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000427
name: small proline-rich protein 2E region 2
namespace: region
def: "." [DPO:curators, PMID:3133554, PMID:9722562]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000015577 ! small proline-rich protein 2E
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000428
name: tropomodulin region 1
namespace: region
def: "." [DPO:curators, PMID:11423419, PMID:15475586]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000429
name: calsequestrin-1 region 1
namespace: region
def: "." [DPO:curators, PMID:4472093, PMID:6725251, PMID:6480588]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000430
name: calsequestrin-1 region 2
namespace: region
def: "." [DPO:curators, PMID:9628486]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000431
name: calsequestrin-1 region 3
namespace: region
def: "." [DPO:curators, PMID:9628486]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000432
name: calsequestrin-1 region 4
namespace: region
def: "." [DPO:curators, PMID:9628486]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000433
name: fragile X mental retardation 1 protein region 1
namespace: region
def: "." [DPO:curators, PMID:10496225]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000043 ! protein-mRNA binding
relationship: has_structural_basis_for_function DPO:000059 ! order to disorder transition

[Term]
id: DPO:000434
name: fragile X mental retardation 1 protein region 2
namespace: region
def: "." [DPO:curators, PMID:10496225]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000043 ! protein-mRNA binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000435
name: heat shock factor protein region 1
namespace: region
def: "." [DPO:curators, PMID:8745404]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000436
name: histone H1.2 region 1
namespace: region
def: "." [DPO:curators, PMID:9109385, PMID:2373370]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000437
name: histone H1.2 region 2
namespace: region
def: "." [DPO:curators, PMID:9109385, PMID:2373370]
is_a: DPO:000010 ! disordered - molten globule region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000058 ! molten globule to order transition

[Term]
id: DPO:000438
name: histone H1.2 region 3
namespace: region
def: "." [DPO:curators, PMID:9109385, PMID:2373370]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000439
name: hirudin variant-1 region 1
namespace: region
def: "." [DPO:curators, PMID:2567183, PMID:3013692]
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000440
name: parathyroid hormone-related protein region 1
namespace: region
def: "." [DPO:curators, PMID:10050767, PMID:8138348]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000013433 ! parathyroid hormone-related protein
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000441
name: parathyroid hormone-related protein region 2
namespace: region
def: "." [DPO:curators, PMID:10050767, PMID:8138348]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000013433 ! parathyroid hormone-related protein
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000442
name: parathyroid hormone-related protein region 3
namespace: region
def: "." [DPO:curators, PMID:10050767, PMID:8138348]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000013433 ! parathyroid hormone-related protein
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000050 ! substrate/ligand binding

[Term]
id: DPO:000443
name: 50S ribosomal protein L27 region 1
namespace: region
def: "." [DPO:curators, PMID:11673426, PMID:3297162]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023832 ! 50S ribosomal protein L27
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000444
name: zinc finger FYVE domain-containing protein 9 [Isoform 1] region 1
namespace: region
def: "." [DPO:curators, PMID:15231848]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000000313 ! sara isoform 1
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000445
name: heat shock protein beta-1 region 1
namespace: region
def: "." [DPO:curators, PMID:7649277]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000008814 ! heat shock protein beta-1
relationship: has_function DPO:000011 ! chaperone
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000446
name: 50S ribosomal protein L33 region 1
namespace: region
def: "." [DPO:curators, PMID:3297162]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023839 ! 50S ribosomal protein L33

[Term]
id: DPO:000447
name: histone RNA hairpin-binding protein region 1
namespace: region
def: "." [DPO:curators, PMID:15260482]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000448
name: 30S ribosomal protein S12 region 1
namespace: region
def: "." [DPO:curators, PMID:6751823]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023865 ! 30S ribosomal protein S12

[Term]
id: DPO:000449
name: 30S ribosomal protein S18 region 1
namespace: region
def: "." [DPO:curators, PMID:6751823]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023871 ! 30S ribosomal protein S18

[Term]
id: DPO:000450
name: 30S ribosomal protein S19 region 1
namespace: region
def: "." [DPO:curators, PMID:6751823]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023872 ! 30S ribosomal protein S19

[Term]
id: DPO:000451
name: DNA repair protein XRCC4 region 1
namespace: region
def: "." [DPO:curators, PMID:11702069]
comment: The experiments were conducted using a fragment of Xrcc4 spanning residues 1 - 213.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000017507 ! DNA repair protein XRCC4
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding

[Term]
id: DPO:000452
name: DNA repair protein XRCC4 region 2
namespace: region
def: "." [DPO:curators, PMID:11702069]
comment: The experiments were conducted using a fragment of Xrcc4 spanning residues 1 - 213.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000017507 ! DNA repair protein XRCC4

[Term]
id: DPO:000453
name: DNA repair protein XRCC4 region 3
namespace: region
def: "." [DPO:curators, PMID:11702069]
comment: The experiments were conducted using a fragment of Xrcc4 spanning residues 1 - 213.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000017507 ! DNA repair protein XRCC4

[Term]
id: DPO:000454
name: DNA repair protein XRCC4 region 4
namespace: region
def: "." [DPO:curators, PMID:11702069]
comment: The experiments were conducted using a fragment of Xrcc4 spanning residues 1 - 213.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000017507 ! DNA repair protein XRCC4
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding

[Term]
id: DPO:000455
name: DNA repair protein XRCC4 region 5
namespace: region
def: "." [DPO:curators, PMID:11080143]
comment: The experiments were conducted using a fragment of Xrcc4 spanning residues 1 - 265.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000017507 ! DNA repair protein XRCC4

[Term]
id: DPO:000456
name: DNA repair protein XRCC4 region 6
namespace: region
def: "." [DPO:curators, PMID:11080143]
comment: This region is disordered in the S subunit. The experiments were conducted using a fragment of Xrcc4 spanning residues 1 - 213.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000017507 ! DNA repair protein XRCC4
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000457
name: GTPase HRas region 1
namespace: region
def: "." [DPO:curators, PMID:9230043]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000458
name: GTPase HRas region 2
namespace: region
def: "." [DPO:curators, PMID:9230043]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000459
name: GTPase HRas region 3
namespace: region
def: "." [DPO:curators, PMID:9230043]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000460
name: GTPase HRas region 4
namespace: region
def: "." [DPO:curators, PMID:9230043, PMID:8142349]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000461
name: GTPase HRas region 5
namespace: region
def: "." [DPO:curators, PMID:8142349, PMID:2406906]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000462
name: GTPase HRas region 6
namespace: region
def: "." [DPO:curators, PMID:9230043]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000463
name: GTPase HRas region 7
namespace: region
def: "." [DPO:curators, PMID:12842038]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000464
name: GTPase HRas region 8
namespace: region
def: "." [DPO:curators, PMID:9230043]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000465
name: GTPase HRas region 9
namespace: region
def: "." [DPO:curators, PMID:9230043]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000466
name: GTPase HRas region 10
namespace: region
def: "." [DPO:curators, PMID:9230043]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000467
name: GTPase HRas region 11
namespace: region
def: "." [DPO:curators, PMID:9230043, PMID:8142349, PMID:2406906]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000468
name: GTPase HRas region 12
namespace: region
def: "." [DPO:curators, PMID:12842038]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000469
name: GTPase HRas region 13
namespace: region
def: "." [DPO:curators, PMID:2406906]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000470
name: GTPase HRas region 14
namespace: region
def: "." [DPO:curators, PMID:2406906]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000471
name: GTPase HRas region 15
namespace: region
def: "." [DPO:curators, PMID:2406906]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000472
name: GTPase HRas region 16
namespace: region
def: "." [DPO:curators, PMID:2406906]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000473
name: GTPase HRas region 17
namespace: region
def: "." [DPO:curators, PMID:9230043]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000474
name: GTPase HRas region 18
namespace: region
def: "." [DPO:curators, PMID:9230043, PMID:8142349]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000475
name: GTPase HRas region 19
namespace: region
def: "." [DPO:curators, PMID:2406906]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000476
name: GTPase HRas region 20
namespace: region
def: "." [DPO:curators, PMID:2406906]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000477
name: SHC-transforming protein 1 region 1
namespace: region
def: "." [DPO:curators, PMID:12906822]
comment: This entry is from the characterization of the experimental fragment in complex with a 12 residue tyrosine-phosphated peptide. The experimental fragment consisted of residues 128 - 318 of the Swiss-Prot sequence.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000003178 ! shc-transforming protein 1
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000478
name: SHC-transforming protein 1 region 2
namespace: region
def: "." [DPO:curators, PMID:12906822]
comment: This entry is from the characterization of a fragment containing residues 17-207 in solution.	 The experimental fragment consisted of residues 128 - 318 of the Swiss-Prot sequence.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000003178 ! shc-transforming protein 1
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000479
name: SHC-transforming protein 1 region 3
namespace: region
def: "." [DPO:curators, PMID:12906822]
comment: This entry is from the characterization of a fragment containing residues 17-207 in solution.	 The experimental fragment consisted of residues 128 - 318 of the Swiss-Prot sequence.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003178 ! shc-transforming protein 1
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000480
name: SHC-transforming protein 1 region 4
namespace: region
def: "." [DPO:curators, PMID:12906822]
comment: This entry is from the characterization of the experimental fragment in complex with a 12 residue tyrosine-phosphated peptide. The experimental fragment consisted of residues 128 - 318 of the Swiss-Prot sequence.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003178 ! shc-transforming protein 1
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000481
name: SHC-transforming protein 1 region 5
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003178 ! shc-transforming protein 1

[Term]
id: DPO:000482
name: syntaxin-1A region 1
namespace: region
def: "." [DPO:curators, PMID:12680753]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000483
name: UV excision repair protein RAD23 homolog A region 1
namespace: region
def: "." [DPO:curators, PMID:14557549]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000013669 ! UV excision repair protein RAD23 A
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000484
name: UV excision repair protein RAD23 homolog A region 2
namespace: region
def: "." [DPO:curators, PMID:14557549]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000013669 ! UV excision repair protein RAD23 A
relationship: has_function DPO:000012 ! entropic chain
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000485
name: UV excision repair protein RAD23 homolog A region 3
namespace: region
def: "." [DPO:curators, PMID:14557549]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000013669 ! UV excision repair protein RAD23 A
relationship: has_function DPO:000012 ! entropic chain
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000486
name: UV excision repair protein RAD23 homolog A region 4
namespace: region
def: "." [DPO:curators, PMID:14557549]
comment: The UBL region interacts with UBA domains of the same protein.  It is unable to bind to both simultaneously, but does so in equilibrium with each.
is_a: DPO:000006 ! ordered region
relationship: part_of PRO:000013669 ! UV excision repair protein RAD23 A
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000052 ! ordered state

[Term]
id: DPO:000487
name: UV excision repair protein RAD23 homolog A region 5
namespace: region
def: "." [DPO:curators, PMID:14557549]
comment: The UBA1 domain binds with the UBL domain of the same protein.  It does so at equilibrium with UBA2.
is_a: DPO:000006 ! ordered region
relationship: part_of PRO:000013669 ! UV excision repair protein RAD23 A
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000052 ! ordered state

[Term]
id: DPO:000488
name: UV excision repair protein RAD23 homolog A region 6
namespace: region
def: "." [DPO:curators, PMID:14557549]
is_a: DPO:000006 ! ordered region
relationship: part_of PRO:000013669 ! UV excision repair protein RAD23 A

[Term]
id: DPO:000489
name: UV excision repair protein RAD23 homolog A region 7
namespace: region
def: "." [DPO:curators, PMID:14557549]
is_a: DPO:000006 ! ordered region
relationship: part_of PRO:000013669 ! UV excision repair protein RAD23 A
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000052 ! ordered state

[Term]
id: DPO:000490
name: cell invasion protein sipA region 1
namespace: region
def: "." [DPO:curators, PMID:14512630]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000491
name: cell invasion protein sipA region 2
namespace: region
def: "." [DPO:curators, PMID:14512630]
is_a: DPO:000006 ! ordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000038 ! polymerization
relationship: has_structural_basis_for_function DPO:000052 ! ordered state

[Term]
id: DPO:000492
name: cell invasion protein sipA region 3
namespace: region
def: "." [DPO:curators, PMID:14512630]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000493
name: ssl1911 protein region 1
namespace: region
def: "." [DPO:curators, PMID:12824490]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000494
name: cadherin-1 region 1
namespace: region
def: "." [DPO:curators, PMID:11121423]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000001447 ! epithelial cadherin
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000495
name: nucleoprotein region 1
namespace: region
def: "." [DPO:curators, PMID:12621042, PMID:3211755]
is_a: DPO:000009 ! disordered - pre-molten globule region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000496
name: cell division protein zipA region 1
namespace: region
def: "." [DPO:curators, PMID:12107152]
comment: The EM used in this study is a novel approach to demonstrate an unstructured protein. The unstructured protein is placed between two small globular domains and imaged by EM. Knowing the contour length, one can determine the persistance lengh from the average spacing of the two globular domains. A persistence length of 0.3-0.6 nm is characteristic of an unstructrured protein.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000024247 ! cell division protein zipA

[Term]
id: DPO:000497
name: stannin region 1
namespace: region
def: "." [DPO:curators, PMID:16246365]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000015329 ! stannin
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000498
name: protein GIR2 region 1
namespace: region
def: "." [DPO:curators, PMID:15896712]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000499
name: 60S acidic ribosomal protein P1-alpha region 1
namespace: region
def: "." [DPO:curators, PMID:10913306]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000500
name: pyridoxine/pyridoxamine 5'-phosphate oxidase region 1
namespace: region
def: "." [DPO:curators, PMID:15858270]
comment: Disorder in this region is found in monomer A of the tetragonal unit cell.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023504 ! pyridoxine/pyridoxamine 5'-phosphate oxidase
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000501
name: pyridoxine/pyridoxamine 5'-phosphate oxidase region 2
namespace: region
def: "." [DPO:curators, PMID:15858270]
comment: Disorder in this region is found in monomer B of the tetragonal unit cell.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023504 ! pyridoxine/pyridoxamine 5'-phosphate oxidase
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000502
name: pyridoxine/pyridoxamine 5'-phosphate oxidase region 3
namespace: region
def: "." [DPO:curators, PMID:15858270]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023504 ! pyridoxine/pyridoxamine 5'-phosphate oxidase
relationship: has_function DPO:000014 ! modification site
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000503
name: pyridoxine/pyridoxamine 5'-phosphate oxidase region 4
namespace: region
def: "." [DPO:curators, PMID:15858270]
comment: Disorder in this region is found in monomer B of the tetragonal unit cell.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023504 ! pyridoxine/pyridoxamine 5'-phosphate oxidase
relationship: has_function DPO:000014 ! modification site
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000504
name: troponin I, cardiac muscle region 1
namespace: region
def: "." [DPO:curators, PMID:12840750]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016506 ! troponin I, cardiac muscle
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000505
name: troponin I, cardiac muscle region 2
namespace: region
def: "." [DPO:curators, PMID:12840750]
comment: This disordered region becomes ordered when in complex with Troponin T.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016506 ! troponin I, cardiac muscle
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000506
name: troponin I, cardiac muscle region 3
namespace: region
def: "." [DPO:curators, PMID:12840750]
comment: This disordered region is thought to be the binding sites for actin and tropomyosin.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016506 ! troponin I, cardiac muscle
relationship: has_function DPO:000012 ! entropic chain
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000507
name: troponin I, cardiac muscle region 4
namespace: region
def: "." [DPO:curators, PMID:12840750]
comment: Residues 163-191 were disordered in one of the two Troponin I molecules that were obtained through crystallization. 
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016506 ! troponin I, cardiac muscle
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000012 ! entropic chain
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000508
name: troponin I, cardiac muscle region 5
namespace: region
def: "." [DPO:curators, PMID:12840750]
comment: This disordered region undergoes a conformational change when interacting with other Troponin moledules.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016506 ! troponin I, cardiac muscle
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000012 ! entropic chain
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000509
name: troponin I, cardiac muscle region 6
namespace: region
def: "." [DPO:curators, PMID:12840750]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000016506 ! troponin I, cardiac muscle
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000510
name: ras-related protein Rap-2a region 1
namespace: region
def: "." [DPO:curators, PMID:9312017]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000013723 ! ras-related protein Rap-2a
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000511
name: ras-related protein Rap-2a region 2
namespace: region
def: "." [DPO:curators, PMID:10591105]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000013723 ! ras-related protein Rap-2a
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000512
name: ras-related protein Rap-2a region 3
namespace: region
def: "." [DPO:curators, PMID:9312017]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000013723 ! ras-related protein Rap-2a
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000513
name: ras-related protein Rap-2a region 4
namespace: region
def: "." [DPO:curators, PMID:10591105]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000013723 ! ras-related protein Rap-2a
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000514
name: ras-related protein Rap-2a region 5
namespace: region
def: "." [DPO:curators, PMID:10591105]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000013723 ! ras-related protein Rap-2a
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000515
name: pyridoxine-5'-phosphate oxidase region 1
namespace: region
def: "." [DPO:curators, PMID:12824491]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012949 ! pyridoxine-5'-phosphate oxidase
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000516
name: tubulin beta-2 chain region 1
namespace: region
def: "." [DPO:curators, PMID:10211825]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000517
name: tubulin beta-2 chain region 2
namespace: region
def: "." [DPO:curators, PMID:10211825]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000518
name: tubulin beta-2 chain region 3
namespace: region
def: "." [DPO:curators, PMID:10211825]
comment: Disorder may be caused by the truncation of this fragment
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000519
name: tubulin beta-2 chain region 4
namespace: region
def: "." [DPO:curators, PMID:10211825]
comment: Disorder may be caused by the truncation of this fragment
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000520
name: tubulin beta-2 chain region 5
namespace: region
def: "." [DPO:curators, PMID:10211825]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000521
name: dehydrin-like protein region 1
namespace: region
def: "." [DPO:curators, PMID:12644649]
is_a: DPO:000008 ! disordered - extended region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000522
name: RAF proto-oncogene serine/threonine-protein kinase region 1
namespace: region
def: "." [DPO:curators, PMID:7791872]
comment: Disordered region may be present due to the fragmentation of the sequence.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003244 ! RAF proto-oncogene serine/threonine-protein kinase

[Term]
id: DPO:000523
name: RAF proto-oncogene serine/threonine-protein kinase region 2
namespace: region
def: "." [DPO:curators, PMID:7766599]
comment: Disordered region may be present due to the fragmentation of the sequence.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003244 ! RAF proto-oncogene serine/threonine-protein kinase

[Term]
id: DPO:000524
name: RAF proto-oncogene serine/threonine-protein kinase region 3
namespace: region
def: "." [DPO:curators, PMID:7766599]
comment: Disordered region may be present due to the fragmentation of the sequence.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003244 ! RAF proto-oncogene serine/threonine-protein kinase

[Term]
id: DPO:000525
name: RAF proto-oncogene serine/threonine-protein kinase region 4
namespace: region
def: "." [DPO:curators, PMID:7766599]
comment: Disordered region may be present due to the fragmentation of the sequence.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003244 ! RAF proto-oncogene serine/threonine-protein kinase

[Term]
id: DPO:000526
name: RAF proto-oncogene serine/threonine-protein kinase region 5
namespace: region
def: "." [DPO:curators, PMID:7791872]
comment: Disordered region may be present due to the fragmentation of the sequence.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003244 ! RAF proto-oncogene serine/threonine-protein kinase

[Term]
id: DPO:000527
name: RAF proto-oncogene serine/threonine-protein kinase region 6
namespace: region
def: "." [DPO:curators, PMID:8756332]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000003244 ! RAF proto-oncogene serine/threonine-protein kinase

[Term]
id: DPO:000528
name: RAF proto-oncogene serine/threonine-protein kinase region 7
namespace: region
def: "." [DPO:curators, PMID:7766599]
comment: Disordered region may be present due to the fragmentation of the sequence.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003244 ! RAF proto-oncogene serine/threonine-protein kinase

[Term]
id: DPO:000529
name: RAF proto-oncogene serine/threonine-protein kinase region 8
namespace: region
def: "." [DPO:curators, PMID:7766599]
comment: Disordered region may be present due to the fragmentation of the sequence.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003244 ! RAF proto-oncogene serine/threonine-protein kinase

[Term]
id: DPO:000530
name: RAF proto-oncogene serine/threonine-protein kinase region 9
namespace: region
def: "." [DPO:curators, PMID:8710867]
comment: Disordered region may be present due to the fragmentation of the sequence.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003244 ! RAF proto-oncogene serine/threonine-protein kinase

[Term]
id: DPO:000531
name: RAF proto-oncogene serine/threonine-protein kinase region 10
namespace: region
def: "." [DPO:curators, PMID:8710867]
comment: Disordered region may be present due to the fragmentation of the sequence.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003244 ! RAF proto-oncogene serine/threonine-protein kinase

[Term]
id: DPO:000532
name: RAF proto-oncogene serine/threonine-protein kinase region 11
namespace: region
def: "." [DPO:curators, PMID:8710867]
comment: Disordered region may be present due to the fragmentation of the sequence.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003244 ! RAF proto-oncogene serine/threonine-protein kinase

[Term]
id: DPO:000533
name: POU domain class 2-associating factor 1 region 1
namespace: region
def: "." [DPO:curators, PMID:10541551]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000013034 ! POU domain class 2-associating factor 1
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000534
name: POU domain class 2-associating factor 1 region 2
namespace: region
def: "." [DPO:curators, PMID:10541551]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000013034 ! POU domain class 2-associating factor 1
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000535
name: POU domain class 2-associating factor 1 region 3
namespace: region
def: "." [DPO:curators, PMID:10541551]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000013034 ! POU domain class 2-associating factor 1
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000536
name: POU domain class 2-associating factor 1 region 4
namespace: region
def: "." [DPO:curators, PMID:10541551]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000013034 ! POU domain class 2-associating factor 1
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000537
name: DNA fragmentation factor subunit alpha [Isoform DFF45] region 1
namespace: region
def: "." [DPO:curators, PMID:11371636]
comment: This fragment is disordered in solution and becomes ordered when it interacts with DFF40.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000002283 ! DNA fragmentation factor subunit alpha isoform 1
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000538
name: stathmin region 1
namespace: region
def: "." [DPO:curators, PMID:12860982, PMID:10675326]
comment: pH had little to no effect upon the disordered regions of this protein.  Temperature however, did play a factor in measurement of the disordered regions.  At lower temperatures, such as 5 C, this protein was found to be extensively helical.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000015759 ! stathmin
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000539
name: transcription factor 7-like 2 region 1
namespace: region
def: "." [DPO:curators, PMID:11237626, PMID:11713476]
comment: In the PDB file, the disorder to order transition upon binding with beta-catenin can be seen: residues 13-25 and 40-50 form alpha helicies upon binding to the armadillo repeats of catenin.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000016186 ! transcription factor 7-like 2
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000540
name: **Fe(3+)-pyochelin receptor** region 1
namespace: region
def: "." [DPO:curators, PMID:16139844]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000541
name: **Fe(3+)-pyochelin receptor** region 2
namespace: region
def: "." [DPO:curators, PMID:16139844]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000050 ! substrate/ligand binding

[Term]
id: DPO:000542
name: **Fe(3+)-pyochelin receptor** region 3
namespace: region
def: "." [DPO:curators, PMID:16139844]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000050 ! substrate/ligand binding

[Term]
id: DPO:000543
name: RNA polymerase II subunit A C-terminal domain phosphatase region 1
namespace: region
def: "." [DPO:curators, PMID:12732728]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000005999 ! RNA polymerase II subunit A C-terminal domain phosphatase
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000544
name: protease A inhibitor 3 region 1
namespace: region
def: "." [DPO:curators, PMID:10655612]
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000545
name: salt-mediated killer protoxin 1 region 1
namespace: region
def: "." [DPO:curators, PMID:9089808]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000546
name: DNA-directed RNA polymerase II subunit RPB1 region 1
namespace: region
def: "." [DPO:curators, PMID:10704311]
comment: The first 8 repeats of SPTSPSY that make up this region are essential.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012987 ! DNA-directed RNA polymerase II subunit RPB1

[Term]
id: DPO:000547
name: DNA-directed RNA polymerase II subunit RPB1 region 2
namespace: region
def: "." [DPO:curators, PMID:10704311]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012987 ! DNA-directed RNA polymerase II subunit RPB1

[Term]
id: DPO:000548
name: ferripyoverdine receptor region 1
namespace: region
def: "." [DPO:curators, PMID:15733922]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000549
name: vitamin D3 receptor region 1
namespace: region
def: "." [DPO:curators, PMID:10678179]
comment: Experimental sequence extended from 410 to 1202 of the SwissProt sequence.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000017283 ! vitamin D3 receptor

[Term]
id: DPO:000550
name: late embryogenesis-abundant protein region 1
namespace: region
def: "." [DPO:curators, PMID:11891239]
is_a: DPO:000008 ! disordered - extended region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000551
name: late embryogenesis abundant protein 1 region 1
namespace: region
def: "." [DPO:curators, PMID:12569097]
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000552
name: major prion protein region 1
namespace: region
def: "." [DPO:curators, PMID:9391046]
is_a: DPO:000008 ! disordered - extended region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000553
name: major prion protein region 2
namespace: region
def: "." [DPO:curators, PMID:9391046]
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000554
name: protein Nef region 1
namespace: region
def: "." [DPO:curators, PMID:10339411]
comment: The experimental protein consisted of residues 2 - 57 of SwissProt entry P04324.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000555
name: protein Nef region 2
namespace: region
def: "." [DPO:curators, PMID:10339411]
comment: The experimental protein consisted of residues 2 - 57 of SwissProt entry P04324.
is_a: DPO:000006 ! ordered region

[Term]
id: DPO:000556
name: protein Nef region 3
namespace: region
def: "." [DPO:curators, PMID:10339411]
comment: The experimental protein consisted of residues 2 - 57 of SwissProt entry P04324.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000557
name: protein Nef region 4
namespace: region
def: "." [DPO:curators, PMID:10339411]
comment: The experimental protein consisted of residues 2 - 57 of SwissProt entry P04324.
is_a: DPO:000006 ! ordered region

[Term]
id: DPO:000558
name: protein Nef region 5
namespace: region
def: "." [DPO:curators, PMID:10339411]
comment: The experimental protein consisted of residues 2 - 57 of SwissProt entry P04324.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000559
name: sulfite reductase [NADPH] flavoprotein alpha-component region 1
namespace: region
def: "." [DPO:curators, PMID:10860732]
comment: This is the FMN binding domain of this protein.  It transfers electrons from the ferredoxin NADP+ reductase (FNR) module to the beta subunit, which contains Fe4S4 and siroheme.  The FMN of one molecule binds to the FNR of an adjacent molecule.  The flexibility of this region is believed to be important in optimal molecular arrangment during electron transfer.    
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022381 ! sulfite reductase [NADPH] flavoprotein alpha-component
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000022 ! cofactor/heme binding
relationship: has_subfunction DPO:000026 ! electron transfer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000560
name: sulfite reductase [NADPH] flavoprotein alpha-component region 2
namespace: region
def: "." [DPO:curators, PMID:10860732]
is_a: DPO:000006 ! ordered region
relationship: part_of PRO:000022381 ! sulfite reductase [NADPH] flavoprotein alpha-component
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000022 ! cofactor/heme binding
relationship: has_structural_basis_for_function DPO:000052 ! ordered state

[Term]
id: DPO:000561
name: sulfite reductase [NADPH] flavoprotein alpha-component region 3
namespace: region
def: "." [DPO:curators, PMID:10860732]
is_a: DPO:000006 ! ordered region
relationship: part_of PRO:000022381 ! sulfite reductase [NADPH] flavoprotein alpha-component
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000562
name: sulfite reductase [NADPH] flavoprotein alpha-component region 4
namespace: region
def: "." [DPO:curators, PMID:10860732]
is_a: DPO:000006 ! ordered region
relationship: part_of PRO:000022381 ! sulfite reductase [NADPH] flavoprotein alpha-component
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000022 ! cofactor/heme binding
relationship: has_structural_basis_for_function DPO:000052 ! ordered state

[Term]
id: DPO:000563
name: sulfite reductase [NADPH] flavoprotein alpha-component region 5
namespace: region
def: "." [DPO:curators, PMID:10860732]
is_a: DPO:000006 ! ordered region
relationship: part_of PRO:000022381 ! sulfite reductase [NADPH] flavoprotein alpha-component

[Term]
id: DPO:000564
name: sulfite reductase [NADPH] flavoprotein alpha-component region 6
namespace: region
def: "." [DPO:curators, PMID:10860732]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022381 ! sulfite reductase [NADPH] flavoprotein alpha-component
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000022 ! cofactor/heme binding
relationship: has_subfunction DPO:000026 ! electron transfer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000565
name: plasminogen region 1
namespace: region
def: "." [DPO:curators, PMID:15299951]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012867 ! plasminogen

[Term]
id: DPO:000566
name: plasminogen region 2
namespace: region
def: "." [DPO:curators, PMID:15299951]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012867 ! plasminogen

[Term]
id: DPO:000567
name: plasminogen region 3
namespace: region
def: "." [DPO:curators, PMID:15299951]
comment: This residue is part of the first disordered residue patch on the surface of the protein.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012867 ! plasminogen

[Term]
id: DPO:000568
name: plasminogen region 4
namespace: region
def: "." [DPO:curators, PMID:15299951]
comment: This residue is part of the second disordered residue patch on the surface of the protein.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012867 ! plasminogen

[Term]
id: DPO:000569
name: plasminogen region 5
namespace: region
def: "." [DPO:curators, PMID:15299951]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012867 ! plasminogen

[Term]
id: DPO:000570
name: plasminogen region 6
namespace: region
def: "." [DPO:curators, PMID:15299951]
comment: This residue is part of the second disordered residue patch on the surface of the protein.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012867 ! plasminogen

[Term]
id: DPO:000571
name: plasminogen region 7
namespace: region
def: "." [DPO:curators, PMID:15299951]
comment: The carbonyl group of this residue is associated with serine 91 via a strong water-mediated hydrogen bond to the nitrogen atom of the amide group.  
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012867 ! plasminogen
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000572
name: plasminogen region 8
namespace: region
def: "." [DPO:curators, PMID:15299951]
comment: Part of a disordered disulfide bridge (with residue 426).
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012867 ! plasminogen

[Term]
id: DPO:000573
name: plasminogen region 9
namespace: region
def: "." [DPO:curators, PMID:15299951]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012867 ! plasminogen

[Term]
id: DPO:000574
name: plasminogen region 10
namespace: region
def: "." [DPO:curators, PMID:15299951]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012867 ! plasminogen

[Term]
id: DPO:000575
name: plasminogen region 11
namespace: region
def: "." [DPO:curators, PMID:15299951]
comment: Part of a disordered disulfide bridge (with residue 449).
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012867 ! plasminogen

[Term]
id: DPO:000576
name: kappa-casein region 1
namespace: region
def: "." [DPO:curators, PMID:11784308]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly

[Term]
id: DPO:000577
name: kappa-casein region 2
namespace: region
def: "." [DPO:curators, PMID:6402987]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000578
name: kappa-casein region 3
namespace: region
def: "." [DPO:curators, PMID:6402987]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000579
name: kappa-casein region 4
namespace: region
def: "." [DPO:curators, PMID:6402987]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000580
name: kappa-casein region 5
namespace: region
def: "." [DPO:curators, PMID:6402987]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000581
name: beta-lactoglobulin region 1
namespace: region
def: "." [DPO:curators, PMID:9141136]
is_a: DPO:000010 ! disordered - molten globule region

[Term]
id: DPO:000582
name: stringent starvation protein B region 1
namespace: region
def: "." [DPO:curators, PMID:14536075]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023993 ! stringent starvation protein B
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000583
name: non-histone chromosomal protein HMG-17 region 1
namespace: region
def: "." [DPO:curators, PMID:565710]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000584
name: calpastatin region 1
namespace: region
def: "." [DPO:curators, PMID:15751971]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000005060 ! calpastatin

[Term]
id: DPO:000585
name: translation initiation factor IF-3 region 1
namespace: region
def: "." [DPO:curators, PMID:9054966]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023014 ! translation initiation factor IF-3
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer

[Term]
id: DPO:000586
name: transcriptional activator protein traR region 1
namespace: region
def: "." [DPO:curators, PMID:11171981]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000587
name: beta-casein region 1
namespace: region
def: "." [DPO:curators, PMID:3074304, PMID:4624541]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000005941 ! beta-casein
relationship: has_function DPO:000014 ! modification site
relationship: has_function DPO:000017 ! molecular recognition scavenger
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000588
name: T-cell surface glycoprotein CD3 zeta chain [Isoform 1] region 1
namespace: region
def: "." [DPO:curators, PMID:14967045]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000001029 ! CD247 isoform CD3 zeta
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000038 ! polymerization
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000589
name: ATP synthase-coupling factor 6, mitochondrial region 1
namespace: region
def: "." [DPO:curators, PMID:15327958]
comment: The SwissProt sequence includes a signal sequence that spans from residue 1 to 32 and was not included in the experimental sequence.
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000590
name: ATP synthase-coupling factor 6, mitochondrial region 2
namespace: region
def: "." [DPO:curators, PMID:15327958]
comment: The SwissProt sequence includes a signal sequence that spans from residue 1 to 32 and was not included in the experimental sequence.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000591
name: ATP synthase-coupling factor 6, mitochondrial region 3
namespace: region
def: "." [DPO:curators, PMID:15327958]
comment: The SwissProt sequence includes a signal sequence that spans from residue 1 to 32 and was not included in the experimental sequence.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000592
name: UPF0243 zinc-binding protein yacG region 1
namespace: region
def: "." [DPO:curators, PMID:12211008]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000593
name: UPF0243 zinc-binding protein yacG region 2
namespace: region
def: "." [DPO:curators, PMID:12211008]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000594
name: thermonuclease region 1
namespace: region
def: "." [DPO:curators, PMID:2780539]
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000595
name: thermonuclease region 2
namespace: region
def: "." [DPO:curators, PMID:1896431]
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000596
name: thermonuclease region 3
namespace: region
def: "." [DPO:curators, PMID:2780539]
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000597
name: thermonuclease region 4
namespace: region
def: "." [DPO:curators, PMID:1896431]
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000598
name: thermonuclease region 5
namespace: region
def: "." [DPO:curators, PMID:1896431]
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000599
name: metal-binding protein smbP region 1
namespace: region
def: "." [DPO:curators, PMID:15366930]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000013 ! metal sponge
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000600
name: fimbrial protein region 1
namespace: region
def: "." [DPO:curators, PMID:11294863]
comment: The experimental sequence consisted of seven residues from the cloning vector followed by residues 8 through 157 of SwissProt sequence P17838.
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000601
name: fimbrial protein region 2
namespace: region
def: "." [DPO:curators, PMID:11294863]
comment: The experimental sequence consisted of seven residues from the cloning vector followed by residues 8 through 157 of SwissProt sequence P17838.
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000602
name: fimbrial protein region 3
namespace: region
def: "." [DPO:curators, PMID:11294863]
comment: The experimental sequence consisted of seven residues from the cloning vector followed by residues 8 through 157 of SwissProt sequence P17838.
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000603
name: fimbrial protein region 4
namespace: region
def: "." [DPO:curators, PMID:11294863]
comment: The experimental sequence consisted of seven residues from the cloning vector followed by residues 8 through 157 of SwissProt sequence P17838.
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000604
name: fimbrial protein region 5
namespace: region
def: "." [DPO:curators, PMID:11294863]
comment: The experimental sequence consisted of seven residues from the cloning vector followed by residues 8 through 157 of SwissProt sequence P17838.
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000605
name: fimbrial protein region 6
namespace: region
def: "." [DPO:curators, PMID:11294863]
comment: The experimental sequence consisted of seven residues from the cloning vector followed by residues 8 through 157 of SwissProt sequence P17838.
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000606
name: ribonuclease E region 1
namespace: region
def: "." [DPO:curators, PMID:15236960]
comment: CTD can be cross-linked to itself, thus forming dimers.   The region that can self-interact is from 500-752 residues. Within the disordered CTD, there are four regions that have predicted structural propensity.  These segments are called RISPs (regions of increased structural propensity).  The RISPs are; segment A- residues 565-585, segment B- residues 633-712, segment C- residues 839-850 and segment D- residues 1021-1061.   
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023789 ! ribonuclease E
relationship: has_subfunction DPO:000045 ! protein-rRNA binding
relationship: has_subfunction DPO:000021 ! autoregulatory
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000607
name: ribonuclease E region 2
namespace: region
def: "." [DPO:curators, PMID:15236960]
comment: The experimental domain included the coiled coil segment B region. The 7SrRNA binding region is within this domain. There is an arginine-rich region within this domain, residues 796-819, that may gain some structure upon the binding to RNA.    This domain contains the portion of the disordered CTD that binds helicase RhlB.  It binds helicase RhlB in a 1:1 ratio.  The binding of helicase RhlB to this domain stimulates the ATPase activity of the helicase.  Binding to the helicase protein does not induce folding of the R-domain.  
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023789 ! ribonuclease E
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000045 ! protein-rRNA binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000608
name: ribonuclease E region 3
namespace: region
def: "." [DPO:curators, PMID:15236960]
comment: This region is completely contained within the R-domain.   This region is disordered because it is within the CTD domain of the protein but it is thought to gain structure upon the binding of RNA. 
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000023789 ! ribonuclease E
relationship: has_subfunction DPO:000045 ! protein-rRNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000609
name: ribonuclease E region 4
namespace: region
def: "." [DPO:curators, PMID:15236960]
comment: This domain contains the entire C segment, residues 839-850.   This fragment is a version of CTD isolated under native conditions without affinity tags. This domain was co-purified with enolase.  The binding region included residues 816-1038.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000023789 ! ribonuclease E
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000610
name: sortase region 1
namespace: region
def: "." [DPO:curators, PMID:11371637, PMID:15117963]
comment: The PDB file does not contain the first 59 amino acids of the sequence (Zhong 2004).  It was shown that the removal of this N terminal region had no effect on the enzymatic activity of the protein.  The disordered region is part of the "catalytic core" of the protein (Ilangovan 2001).
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000611
name: beta-defensin 12 region 1
namespace: region
def: "." [DPO:curators, PMID:7577957]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000612
name: growth factor receptor-bound protein 2 region 1
namespace: region
def: "." [DPO:curators, PMID:11178911]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000008224 ! growth factor receptor-bound protein 2
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000613
name: growth factor receptor-bound protein 2 region 2
namespace: region
def: "." [DPO:curators, PMID:11178911]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000008224 ! growth factor receptor-bound protein 2
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000614
name: insulin-like growth factor-binding protein 6 region 1
namespace: region
def: "." [DPO:curators, PMID:15308688]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000008952 ! insulin-like growth factor-binding protein 6

[Term]
id: DPO:000615
name: insulin-like growth factor-binding protein 6 region 2
namespace: region
def: "." [DPO:curators, PMID:15308688]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000008952 ! insulin-like growth factor-binding protein 6

[Term]
id: DPO:000616
name: insulin-like growth factor-binding protein 6 region 3
namespace: region
def: "." [DPO:curators, PMID:15308688]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000008952 ! insulin-like growth factor-binding protein 6

[Term]
id: DPO:000617
name: osteopontin region 1
namespace: region
def: "." [DPO:curators, PMID:11162539]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000015561 ! osteopontin
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000618
name: wiskott-Aldrich syndrome protein region 1
namespace: region
def: "." [DPO:curators, PMID:10724160]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000017371 ! wiskott-Aldrich syndrome protein
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000619
name: wiskott-Aldrich syndrome protein region 2
namespace: region
def: "." [DPO:curators, PMID:10724160]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000017371 ! wiskott-Aldrich syndrome protein
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000620
name: wiskott-Aldrich syndrome protein region 3
namespace: region
def: "." [DPO:curators, PMID:10724160]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000017371 ! wiskott-Aldrich syndrome protein

[Term]
id: DPO:000621
name: BN28a region 1
namespace: region
def: "." [DPO:curators, PMID:9046590]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000622
name: nucleoplasmin region 1
namespace: region
def: "." [DPO:curators, PMID:11248694]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000623
name: protein phosphatase 1 regulatory subunit 12A [Isoform 2] region 1
namespace: region
def: "." [DPO:curators, PMID:15164081]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000624
name: protein phosphatase 1 regulatory subunit 11 region 1
namespace: region
def: "." [DPO:curators, PMID:9843442]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000013106 ! protein phosphatase 1 regulatory subunit 11
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000625
name: peripherin-2 region 1
namespace: region
def: "." [DPO:curators]
is_a: DPO:000008 ! disordered - extended region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000626
name: involucrin region 1
namespace: region
def: "." [DPO:curators, PMID:10601302]
comment: Experimental fragment was three repeats of LEQQEGQLEH. This consensus repeat sequence had the following deviations from the native sequence; E248Q and E354K. Note that there are several LEQQEGQLEH repeats in native sequence.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000009167 ! involucrin

[Term]
id: DPO:000627
name: involucrin region 2
namespace: region
def: "." [DPO:curators, PMID:10601302]
comment: The experimental sequence consisted of three repeats of PEQQEGQLEL.  Note that there are several PEQQEGQLEL repeats in the native sequence.  
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000009167 ! involucrin

[Term]
id: DPO:000628
name: nucleoporin NUP2 region 1
namespace: region
def: "." [DPO:curators, PMID:12065587]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000629
name: G2/mitotic-specific cyclin-B1 region 1
namespace: region
def: "." [DPO:curators, PMID:12220679]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000005116 ! G2/mitotic-specific cyclin-B1
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000630
name: transcription factor 4 region 1
namespace: region
def: "." [DPO:curators, PMID:11237626]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000016183 ! transcription factor 4
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000631
name: transcription factor 4 region 2
namespace: region
def: "." [DPO:curators, PMID:11237626]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000016183 ! transcription factor 4
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000632
name: transcription factor 4 region 3
namespace: region
def: "." [DPO:curators, PMID:11237626]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000016183 ! transcription factor 4
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000633
name: clathrin coat assembly protein AP180 region 1
namespace: region
def: "." [DPO:curators, PMID:11756460]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000634
name: calcyclin-binding protein region 1
namespace: region
def: "." [DPO:curators, PMID:15996101]
is_a: DPO:000006 ! ordered region
relationship: part_of PRO:000004958 ! calcyclin-binding protein
relationship: has_structural_basis_for_function DPO:000052 ! ordered state

[Term]
id: DPO:000635
name: calcyclin-binding protein region 2
namespace: region
def: "." [DPO:curators, PMID:15996101]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000004958 ! calcyclin-binding protein
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000636
name: calcyclin-binding protein region 3
namespace: region
def: "." [DPO:curators, PMID:15996101]
is_a: DPO:000006 ! ordered region
relationship: part_of PRO:000004958 ! calcyclin-binding protein
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000052 ! ordered state

[Term]
id: DPO:000637
name: calcyclin-binding protein region 4
namespace: region
def: "." [DPO:curators, PMID:15996101]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000004958 ! calcyclin-binding protein
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000638
name: omega gliadin storage protein region 1
namespace: region
def: "." [DPO:curators, PMID:12741823]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000639
name: voltage-dependent L-type calcium channel subunit alpha-1S region 1
namespace: region
def: "." [DPO:curators, PMID:12620094]
comment: Peptide C is sufficient to activate the ryanodine receptor at physiological concentrations. Structure determination experiments were conducted on isolated peptide C.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000640
name: lupus La protein region 1
namespace: region
def: "." [DPO:curators, PMID:12842046]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000015647 ! lupus La protein

[Term]
id: DPO:000641
name: lupus La protein region 2
namespace: region
def: "." [DPO:curators, PMID:16387655]
comment: This disordered protein entry is based solely on missing electron density in the Protein Data Bank.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000015647 ! lupus La protein

[Term]
id: DPO:000642
name: lupus La protein region 3
namespace: region
def: "." [DPO:curators, PMID:16387655]
comment: This disordered protein entry is based solely on missing electron density in the Protein Data Bank.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000015647 ! lupus La protein

[Term]
id: DPO:000643
name: lupus La protein region 4
namespace: region
def: "." [DPO:curators, PMID:12842046]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000015647 ! lupus La protein

[Term]
id: DPO:000644
name: lupus La protein region 5
namespace: region
def: "." [DPO:curators, PMID:15004549]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000015647 ! lupus La protein
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000645
name: growth factor receptor-bound protein 14 region 1
namespace: region
def: "." [DPO:curators, PMID:14623073]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000008223 ! growth factor receptor-bound protein 14
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000646
name: POU domain, class 2, transcription factor 1 region 1
namespace: region
def: "." [DPO:curators, PMID:11380252]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000013035 ! POU domain, class 2, transcription factor 1
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000647
name: POU domain, class 2, transcription factor 1 region 2
namespace: region
def: "." [DPO:curators, PMID:11380252]
comment: There was no increase in structure when a fragment of Oct-1 containing the activation domain was incubated with the binding partner, Bob-1.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000013035 ! POU domain, class 2, transcription factor 1
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000648
name: POU domain, class 2, transcription factor 1 region 3
namespace: region
def: "." [DPO:curators, PMID:8479524, PMID:8156594]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000013035 ! POU domain, class 2, transcription factor 1
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000649
name: POU domain, class 2, transcription factor 1 region 4
namespace: region
def: "." [DPO:curators, PMID:8479524]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000013035 ! POU domain, class 2, transcription factor 1
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000650
name: protein phosphatase inhibitor 2 region 1
namespace: region
def: "." [DPO:curators, PMID:6245879, PMID:10807923]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000651
name: fibrinogen alpha chain [Isoform 1 (Alpha-E)] region 1
namespace: region
def: "." [DPO:curators, PMID:11601975]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000652
name: fibrinogen alpha chain [Isoform 1 (Alpha-E)] region 2
namespace: region
def: "." [DPO:curators, PMID:11601975]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000653
name: fibrinogen beta chain region 1
namespace: region
def: "." [DPO:curators, PMID:11601975]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000654
name: fibrinogen gamma chain region 1
namespace: region
def: "." [DPO:curators, PMID:11601975]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000655
name: fibrinogen gamma chain region 2
namespace: region
def: "." [DPO:curators, PMID:11601975]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000656
name: myelin basic protein region 1
namespace: region
def: "." [DPO:curators, PMID:7500383]
comment: The experimental sequence was the 18.5 kDa isoform and therefore did not include residues 1 - 133 of the sequence listed in SwissProt.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000010228 ! myelin basic protein
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000657
name: myelin basic protein region 1
namespace: region
def: "." [DPO:curators, PMID:12372316]
comment: The experimental sequence was the 18.5 kDa isoform. The experimental sequence had a C-terminal hexahistidine tagged.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000010228 ! myelin basic protein
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000658
name: breast cancer type 1 susceptibility protein region 1
namespace: region
def: "." [DPO:curators, PMID:15571721]
comment: The structure of the 1480 residue central region was investigated by characterizing 21 different fragments.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000004803 ! breast cancer type 1 susceptibility protein
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000659
name: breast cancer type 1 susceptibility protein region 2
namespace: region
def: "." [DPO:curators, PMID:15609993]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000004803 ! breast cancer type 1 susceptibility protein

[Term]
id: DPO:000660
name: breast cancer type 1 susceptibility protein region 3
namespace: region
def: "." [DPO:curators, PMID:15609993]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000004803 ! breast cancer type 1 susceptibility protein

[Term]
id: DPO:000661
name: breast cancer type 1 susceptibility protein region 4
namespace: region
def: "." [DPO:curators, PMID:15609993]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000004803 ! breast cancer type 1 susceptibility protein

[Term]
id: DPO:000662
name: breast cancer type 1 susceptibility protein region 5
namespace: region
def: "." [DPO:curators, PMID:15609993]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000004803 ! breast cancer type 1 susceptibility protein

[Term]
id: DPO:000663
name: carbon monoxide dehydrogenase region 1
namespace: region
def: "." [DPO:curators, PMID:11593006]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000664
name: carbon monoxide dehydrogenase region 2
namespace: region
def: "." [DPO:curators, PMID:11593006]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000665
name: alpha-adducin [Isoform 1] region 1
namespace: region
def: "." [DPO:curators, PMID:7642559]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000666
name: beta-adducin [Isoform 1] region 1
namespace: region
def: "." [DPO:curators, PMID:7642559]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000667
name: 30S ribosomal protein S17 region 1
namespace: region
def: "." [DPO:curators, PMID:6751823]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023870 ! 30S ribosomal protein S17
relationship: has_function DPO:000015 ! molecular assembly

[Term]
id: DPO:000668
name: DNA-repair protein complementing XP-A cells region 1
namespace: region
def: "." [DPO:curators, PMID:9699634, PMID:10050037]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000017493 ! DNA repair protein complementing XP-A cells

[Term]
id: DPO:000669
name: DNA-repair protein complementing XP-A cells region 2
namespace: region
def: "." [DPO:curators, PMID:9699634, PMID:10050037]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000017493 ! DNA repair protein complementing XP-A cells

[Term]
id: DPO:000670
name: DNA-repair protein complementing XP-A cells region 3
namespace: region
def: "." [DPO:curators, PMID:9699634, PMID:10050037]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000017493 ! DNA repair protein complementing XP-A cells

[Term]
id: DPO:000671
name: DNA-repair protein complementing XP-A cells region 4
namespace: region
def: "." [DPO:curators, PMID:9699634, PMID:10050037]
is_a: DPO:000006 ! ordered region
relationship: part_of PRO:000017493 ! DNA repair protein complementing XP-A cells

[Term]
id: DPO:000672
name: DNA-repair protein complementing XP-A cells region 5
namespace: region
def: "." [DPO:curators, PMID:9699634, PMID:10050037]
is_a: DPO:000006 ! ordered region
relationship: part_of PRO:000017493 ! DNA repair protein complementing XP-A cells

[Term]
id: DPO:000673
name: DNA-repair protein complementing XP-A cells region 6
namespace: region
def: "." [DPO:curators, PMID:9699634, PMID:10050037]
is_a: DPO:000006 ! ordered region
relationship: part_of PRO:000017493 ! DNA repair protein complementing XP-A cells

[Term]
id: DPO:000674
name: cAMP-dependent protein kinase type I-alpha regulatory subunit region 1
namespace: region
def: "." [DPO:curators, PMID:15692043, PMID:6487597]
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000675
name: macrophage scavenger receptor types I and II [Isoform 1] region 1
namespace: region
def: "." [DPO:curators, PMID:11785981]
comment: The experimental sequence consisted of the first 50 residues of bovine MSR with a C17A substitution and a GC appended to the C-terminus. The C17A substitution has been shown to have no affect on the cell surface expression and endocytosis of MSR.
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000676
name: probable transcriptional regulatory protein pdtaR region 1
namespace: region
def: "." [DPO:curators, PMID:15341725]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000677
name: probable transcriptional regulatory protein pdtaR region 2
namespace: region
def: "." [DPO:curators, PMID:15341725]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000678
name: probable transcriptional regulatory protein pdtaR region 3
namespace: region
def: "." [DPO:curators, PMID:15341725]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000679
name: acylamino-acid-releasing enzyme region 1
namespace: region
def: "." [DPO:curators, PMID:15296741]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000680
name: acylamino-acid-releasing enzyme region 2
namespace: region
def: "." [DPO:curators, PMID:15296741]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000681
name: acylamino-acid-releasing enzyme region 3
namespace: region
def: "." [DPO:curators, PMID:15296741]
comment: This region is disordered when in a complex with p-nitrophenyl phosphate (pNP).
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000682
name: troponin C, slow skeletal and cardiac muscles region 1
namespace: region
def: "." [DPO:curators, PMID:2933134]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000683
name: cholera enterotoxin subunit A region 1
namespace: region
def: "." [DPO:curators, PMID:15049684]
comment: This region is disordered in crystal form 1.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000021962 ! cholera enterotoxin subunit A
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000684
name: cholera enterotoxin subunit A region 2
namespace: region
def: "." [DPO:curators, PMID:15049684]
comment: This region is disordered in crystal form 2.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000021962 ! cholera enterotoxin subunit A
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000685
name: cholera enterotoxin subunit A region 3
namespace: region
def: "." [DPO:curators, PMID:15049684]
comment: This region is disordered in crystal form 3.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000021962 ! cholera enterotoxin subunit A
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000686
name: epsin-1 region 1
namespace: region
def: "." [DPO:curators, PMID:11756460]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000687
name: tryptophan synthase alpha chain region 1
namespace: region
def: "." [DPO:curators, PMID:15667212]
comment: These densities were unclear in molecule A only.  The region stayed disordered when in a complex with molecule B.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000024117 ! tryptophan synthase alpha chain
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000059 ! order to disorder transition

[Term]
id: DPO:000688
name: tryptophan synthase alpha chain region 2
namespace: region
def: "." [DPO:curators, PMID:15667212]
comment: These densities were unclear in molecules A and B.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000024117 ! tryptophan synthase alpha chain

[Term]
id: DPO:000689
name: tryptophan synthase alpha chain region 3
namespace: region
def: "." [DPO:curators, PMID:15667212]
comment: These densities are unclear in molecule B only.  The region stayed disordered when in complex with molecule A.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000024117 ! tryptophan synthase alpha chain
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000059 ! order to disorder transition

[Term]
id: DPO:000690
name: myristoylated alanine-rich C-kinase substrate region 1
namespace: region
def: "." [DPO:curators, PMID:9468306, PMID:15640140]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000010184 ! myristoylated alanine-rich C-kinase substrate
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000691
name: myristoylated alanine-rich C-kinase substrate region 2
namespace: region
def: "." [DPO:curators, PMID:9468306, PMID:15640140]
comment: This protein was found to be disordered while in a complex with calmodulin.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000010184 ! myristoylated alanine-rich C-kinase substrate
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000692
name: protein tyrosine phosphatase type IVA 3 [Isoform 1] region 1
namespace: region
def: "." [DPO:curators, PMID:14704153]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000693
name: protein tyrosine phosphatase type IVA 3 [Isoform 1] region 2
namespace: region
def: "." [DPO:curators, PMID:14704153]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000694
name: protein tyrosine phosphatase type IVA 3 [Isoform 1] region 3
namespace: region
def: "." [DPO:curators, PMID:14704153]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000695
name: protein tyrosine phosphatase type IVA 1 [Isoform 1] region 1
namespace: region
def: "." [DPO:curators, PMID:15213447]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000013440 ! protein tyrosine phosphatase type IVA 1

[Term]
id: DPO:000696
name: protein tyrosine phosphatase type IVA 1 [Isoform 1] region 2
namespace: region
def: "." [DPO:curators, PMID:15213447]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000013440 ! protein tyrosine phosphatase type IVA 1

[Term]
id: DPO:000697
name: protein tyrosine phosphatase type IVA 1 [Isoform 1] region 3
namespace: region
def: "." [DPO:curators, PMID:15213447]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000013440 ! protein tyrosine phosphatase type IVA 1

[Term]
id: DPO:000698
name: securin region 1
namespace: region
def: "." [DPO:curators, PMID:12220679]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000699
name: superoxide dismutase-like protein yojM region 1
namespace: region
def: "." [DPO:curators, PMID:15897454]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000700
name: superoxide dismutase-like protein yojM region 2
namespace: region
def: "." [DPO:curators, PMID:15897454]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000701
name: superoxide dismutase-like protein yojM region 3
namespace: region
def: "." [DPO:curators, PMID:15897454]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000702
name: superoxide dismutase-like protein yojM region 4
namespace: region
def: "." [DPO:curators, PMID:15897454]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000703
name: lysozyme C region 1
namespace: region
def: "." [DPO:curators, PMID:1515108, PMID:15805597]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000704
name: lysozyme C region 2
namespace: region
def: "." [DPO:curators, PMID:15805597]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000705
name: lysozyme C region 3
namespace: region
def: "." [DPO:curators, PMID:15805597]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000706
name: lysozyme C region 4
namespace: region
def: "." [DPO:curators, PMID:15805597]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000707
name: lysozyme C region 5
namespace: region
def: "." [DPO:curators, PMID:15805597]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000708
name: myc proto-oncogene protein [Isoform 1] region 1
namespace: region
def: "." [DPO:curators, PMID:15663936]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000000228 ! c-myc protein isoform 1
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)

[Term]
id: DPO:000709
name: myc proto-oncogene protein [Isoform 1] region 2
namespace: region
def: "." [DPO:curators, PMID:15663936]
is_a: DPO:000010 ! disordered - molten globule region
relationship: part_of PRO:000000228 ! c-myc protein isoform 1
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000055 ! molten globule state

[Term]
id: DPO:000710
name: myc proto-oncogene protein [Isoform 1] region 3
namespace: region
def: "." [DPO:curators, PMID:8755740, PMID:15663936]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000000228 ! c-myc protein isoform 1
relationship: has_function DPO:000014 ! modification site
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000711
name: sialidase-2 region 1
namespace: region
def: "." [DPO:curators, PMID:15501818]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000011146 ! sialidase-2
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000712
name: sialidase-2 region 2
namespace: region
def: "." [DPO:curators, PMID:15501818]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000011146 ! sialidase-2
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000713
name: hypoxia-inducible factor 1 alpha [Isoform 1] region 1
namespace: region
def: "." [DPO:curators, PMID:15629713]
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000714
name: hypoxia-inducible factor 1 alpha [Isoform 1] region 2
namespace: region
def: "." [DPO:curators, PMID:15629713]
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000715
name: hypoxia-inducible factor 1 alpha [Isoform 1] region 3
namespace: region
def: "." [DPO:curators, PMID:11959977]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000716
name: fatty acid-binding protein, intestinal region 1
namespace: region
def: "." [DPO:curators, PMID:9063893]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000717
name: fatty acid-binding protein, intestinal region 2
namespace: region
def: "." [DPO:curators, PMID:9063893]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000718
name: major prion protein region 1
namespace: region
def: "." [DPO:curators, PMID:9280298]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000001886 ! major prion protein

[Term]
id: DPO:000719
name: potassium voltage-gated channel protein Shaker [Isoform E] region 1
namespace: region
def: "." [DPO:curators, PMID:2122519]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000028 ! entropic clock
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000720
name: DE-cadherin region 1
namespace: region
def: "." [DPO:curators, PMID:11121423, PMID:7958432]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000721
name: **Fab DNA-1** region 1
namespace: region
def: "." [DPO:curators, PMID:15784256]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000722
name: **Fab DNA-1** region 2
namespace: region
def: "." [DPO:curators, PMID:7506692, PMID:15784256]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000723
name: rhodopsin region 1
namespace: region
def: "." [DPO:curators, PMID:10926528]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000724
name: rhodopsin region 2
namespace: region
def: "." [DPO:curators, PMID:10926528]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000725
name: rhodopsin region 3
namespace: region
def: "." [DPO:curators, PMID:10926528]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000726
name: rhodopsin region 4
namespace: region
def: "." [DPO:curators, PMID:10926528]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000727
name: rhodopsin region 5
namespace: region
def: "." [DPO:curators, PMID:10926528]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000728
name: mu-type opioid receptor [Isoform 1] region 1
namespace: region
def: "." [DPO:curators, PMID:15680247]
comment: The fragment used for structure determination contained residues 97-176 of the human µR.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector

[Term]
id: DPO:000729
name: guanine nucleotide-binding protein G(t) subunit alpha-1 region 1
namespace: region
def: "." [DPO:curators, PMID:9539726]
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000059 ! order to disorder transition

[Term]
id: DPO:000730
name: collagen alpha-1(II) chain [Isoform 2] region 1
namespace: region
def: "." [DPO:curators, PMID:15466413]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000731
name: yersinia crystallin region 1
namespace: region
def: "." [DPO:curators, PMID:15536081]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000013 ! metal sponge
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000732
name: yersinia crystallin region 2
namespace: region
def: "." [DPO:curators, PMID:15536081, PMID:16470515]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000013 ! metal sponge
relationship: has_subfunction DPO:000034 ! metal binding

[Term]
id: DPO:000733
name: membrane fusion protein p14 region 1
namespace: region
def: "." [DPO:curators, PMID:15448165]
comment: This region contains an extended "loop structure" comprising residues Pro5 to Pro13.
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000734
name: membrane fusion protein p14 region 2
namespace: region
def: "." [DPO:curators, PMID:15448165]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000735
name: cytochrome c oxidase copper chaperone region 1
namespace: region
def: "." [DPO:curators, PMID:15465825]
comment: This is the Cox17 protein in the apo form
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000736
name: cytochrome c oxidase copper chaperone region 2
namespace: region
def: "." [DPO:curators, PMID:15465825]
comment: This is the Cox17 protein in complex with copper.
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000737
name: cytochrome c oxidase copper chaperone region 3
namespace: region
def: "." [DPO:curators, PMID:15465825]
comment: This is the Cox17 protein is its apo form.
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000738
name: cytochrome c oxidase copper chaperone region 4
namespace: region
def: "." [DPO:curators, PMID:15465825]
comment: This is the Cox17 protein in complex with copper.
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000739
name: gap junction alpha-1 protein region 1
namespace: region
def: "." [DPO:curators, PMID:15492000, PMID:14699011, PMID:12151412, PMID:15284189]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000740
name: gap junction alpha-1 protein region 2
namespace: region
def: "." [DPO:curators, PMID:15492000, PMID:14699011, PMID:12151412, PMID:15284189]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000741
name: gap junction alpha-1 protein region 3
namespace: region
def: "." [DPO:curators, PMID:15492000, PMID:14699011, PMID:12151412, PMID:15284189]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000742
name: olfactory marker protein region 1
namespace: region
def: "." [DPO:curators, PMID:16008352]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000743
name: olfactory marker protein region 2
namespace: region
def: "." [DPO:curators, PMID:16008352]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000744
name: olfactory marker protein region 3
namespace: region
def: "." [DPO:curators, PMID:16008352]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000745
name: perfringolysin O region 1
namespace: region
def: "." [DPO:curators, PMID:15797734, PMID:10555145]
comment: The six alpha-helices in domain 3 undergo a conformational change into two beta-hairpins that span the membrane.  This order to order transition proceeds through a disordered intermediate.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000746
name: perfringolysin O region 2
namespace: region
def: "." [DPO:curators, PMID:15797734, PMID:10555145]
comment: The six alpha-helices in domain 3 undergo a conformational change into two beta-hairpins that span the membrane.  This order to order transition proceeds through a disordered intermediate.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000747
name: copper-transporting ATPase 1 [Isoform 4] region 1
namespace: region
def: "." [DPO:curators, PMID:14572476]
comment: A single point mutation of MNKr2 was created with a F72I substitution, as discussed in the Jones et al. article.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000748
name: copper-transporting ATPase 1 [Isoform 4] region 2
namespace: region
def: "." [DPO:curators, PMID:15035611, PMID:14572476]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000749
name: copper-transporting ATPase 1 [Isoform 4] region 3
namespace: region
def: "." [DPO:curators, PMID:14572476]
comment: A single point mutation of MNKr2 was created with a F72I substitution, as discussed in the Jones et al. article.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000750
name: **Tail-associated lysozyme** region 1
namespace: region
def: "." [DPO:curators, PMID:15701513]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000050 ! substrate/ligand binding

[Term]
id: DPO:000751
name: glutenin, high molecular weight subunit DX5 region 1
namespace: region
def: "." [DPO:curators, PMID:12741823]
is_a: DPO:000009 ! disordered - pre-molten globule region

[Term]
id: DPO:000752
name: von Hippel-Lindau disease tumor suppressor [Isoform 1] region 1
namespace: region
def: "." [DPO:curators, PMID:14963040]
comment: The physiological role of pVHL is not fully understood. However, it is suggested to play a role in protein degradation in the ubiquitin pathway and to be a regulator of multiple transcription pathways.
is_a: DPO:000010 ! disordered - molten globule region
relationship: has_structural_basis_for_function DPO:000055 ! molten globule state

[Term]
id: DPO:000753
name: prevent host death protein region 1
namespace: region
def: "." [DPO:curators, PMID:9915794]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000754
name: EntI protein region 1
namespace: region
def: "." [DPO:curators, PMID:12832790, PMID:15753083]
comment: This region was disordered in chain A of the native molecule.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000755
name: EntI protein region 2
namespace: region
def: "." [DPO:curators, PMID:12832790, PMID:15753083]
comment: This region was disordered in chain A of the native molecule.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000756
name: EntI protein region 3
namespace: region
def: "." [DPO:curators, PMID:12832790, PMID:15753083]
comment: This region was disordered in chain B of the native molecule.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000757
name: EntI protein region 4
namespace: region
def: "." [DPO:curators, PMID:12832790, PMID:15753083]
comment: This region was disordered in chain B of the native molecule.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000758
name: EntI protein region 5
namespace: region
def: "." [DPO:curators, PMID:12832790, PMID:15753083]
comment: This region was disordered in chain C of the native molecule.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000759
name: EntI protein region 6
namespace: region
def: "." [DPO:curators, PMID:12832790, PMID:15753083]
comment: This region was disordered in chain C of the native molecule.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000760
name: EntI protein region 7
namespace: region
def: "." [DPO:curators, PMID:15753083]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000761
name: EntI protein region 8
namespace: region
def: "." [DPO:curators, PMID:15753083]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000762
name: EscJ region 1
namespace: region
def: "." [DPO:curators, PMID:15752191]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000763
name: calsenilin [Isoform 1] region 1
namespace: region
def: "." [DPO:curators, PMID:15746104]
comment: DREAM-C is a mutant containing residues 65-256 of the full length protein, and contains the mutant residues D150N, E186Q, and E234Q.
is_a: DPO:000010 ! disordered - molten globule region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000764
name: phosphorelay protein luxU region 1
namespace: region
def: "." [DPO:curators, PMID:15740742]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000765
name: phosphorelay protein luxU region 2
namespace: region
def: "." [DPO:curators, PMID:15740742]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000766
name: phosphorelay protein luxU region 3
namespace: region
def: "." [DPO:curators, PMID:15740742]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000767
name: phosphorelay protein luxU region 4
namespace: region
def: "." [DPO:curators, PMID:15740742]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000768
name: methyl-accepting chemotaxis protein II region 1
namespace: region
def: "." [DPO:curators, PMID:15774032]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000024026 ! methyl-accepting chemotaxis protein II
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000769
name: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase region 1
namespace: region
def: "." [DPO:curators, PMID:15735341]
comment: This region was disordered in chain A. This region contained an additional C-terminal His tag that was composed of the following residues:  GVPRGAAALEHHHHHH.  These residues were also found to be disordered in the experiment.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000033 ! intraprotein interaction
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000770
name: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase region 2
namespace: region
def: "." [DPO:curators, PMID:15735341]
comment: This region was disordered in chain B. This region contained an additional C-terminal His tag that was composed of the following residues:  GVPRGAAALEHHHHHH.  These residues were also found to be disordered in the experiment.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000033 ! intraprotein interaction
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000771
name: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase region 3
namespace: region
def: "." [DPO:curators, PMID:15735341]
comment: This region was disordered in chain C. This region contained an additional C-terminal His tag that was composed of the following residues:  GVPRGAAALEHHHHHH.  These residues were also found to be disordered in the experiment.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000033 ! intraprotein interaction
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000772
name: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase region 4
namespace: region
def: "." [DPO:curators, PMID:15735341]
comment: This region was disordered in chain D. This region contained an additional C-terminal His tag that was composed of the following residues:  GVPRGAAALEHHHHHH.  These residues were also found to be disordered in the experiment.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000033 ! intraprotein interaction
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000773
name: PemI-like protein 1 region 1
namespace: region
def: "." [DPO:curators, PMID:12743116, PMID:15735309]
comment: This region is disordered while complexed with the protein fragment VHH.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000774
name: PemI-like protein 1 region 2
namespace: region
def: "." [DPO:curators, PMID:15735309, PMID:12743116]
comment: The PDB files have this region starting at R48. This region is disordered while complexed with the protein fragment VHH.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000020 ! apoptosis
relationship: has_structural_basis_for_function DPO:000066 ! disorder to molten globule transition

[Term]
id: DPO:000775
name: PemI-like protein 1 region 3
namespace: region
def: "." [DPO:curators, PMID:12718874, PMID:15735309]
comment: This region is disordered while complexed with the protein MazF.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000020 ! apoptosis
relationship: has_structural_basis_for_function DPO:000066 ! disorder to molten globule transition

[Term]
id: DPO:000776
name: apoptosis regulator Bcl-2 region 1
namespace: region
def: "." [DPO:curators, PMID:15733859]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000002307 ! apoptosis regulator Bcl-2
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000777
name: bcl-2-like protein 1 region 1
namespace: region
def: "." [DPO:curators, PMID:8692274]
comment: The PDB file 1R2G has this region being disordered from S28 to I81.  
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000002308 ! Bcl-2-like protein 1

[Term]
id: DPO:000778
name: bcl-2-like protein 1 region 2
namespace: region
def: "." [DPO:curators, PMID:8692274]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000002308 ! Bcl-2-like protein 1

[Term]
id: DPO:000779
name: bcl-2-like protein 1 region 3
namespace: region
def: "." [DPO:curators, PMID:14534311]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000002308 ! Bcl-2-like protein 1

[Term]
id: DPO:000780
name: bcl-2-like protein 1 region 4
namespace: region
def: "." [DPO:curators, PMID:14534311]
comment: This disordered region contains an extra poly-histine tail at the C-terminus of the fragment that was added in the experiment to facilitate purification.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000002308 ! Bcl-2-like protein 1

[Term]
id: DPO:000781
name: bcl-2-like protein 1 region 5
namespace: region
def: "." [DPO:curators, PMID:14534311]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000002308 ! Bcl-2-like protein 1

[Term]
id: DPO:000782
name: bcl-2-like protein 1 region 6
namespace: region
def: "." [DPO:curators, PMID:14534311]
comment: This disordered region contains an extra poly-histine tail at the C-terminus of the fragment that was added in the experiment to facilitate purification.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000002308 ! Bcl-2-like protein 1

[Term]
id: DPO:000783
name: PemK-like protein 1 region 1
namespace: region
def: "." [DPO:curators, PMID:12718874]
comment: Molecule B
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022284 ! pemK-like protein 1
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000020 ! apoptosis
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000784
name: PemK-like protein 1 region 2
namespace: region
def: "." [DPO:curators, PMID:12718874]
comment: Molecule A
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022284 ! pemK-like protein 1
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000020 ! apoptosis
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000785
name: PemK-like protein 1 region 3
namespace: region
def: "." [DPO:curators, PMID:12718874]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022284 ! pemK-like protein 1

[Term]
id: DPO:000786
name: methyl-accepting chemotaxis protein I region 1
namespace: region
def: "." [DPO:curators, PMID:15774032]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000024134 ! methyl-accepting chemotaxis protein I
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000787
name: dihydrofolate reductase region 1
namespace: region
def: "." [DPO:curators, PMID:14717591, PMID:9012674]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000788
name: dihydrofolate reductase region 2
namespace: region
def: "." [DPO:curators, PMID:14717591, PMID:9012674]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000789
name: dihydrofolate reductase region 3
namespace: region
def: "." [DPO:curators, PMID:14717591, PMID:9012674]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000790
name: dihydrofolate reductase region 4
namespace: region
def: "." [DPO:curators, PMID:9012674, PMID:14717591]
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000791
name: dihydrofolate reductase region 5
namespace: region
def: "." [DPO:curators, PMID:9012674, PMID:14717591]
comment: PDB ID 5DFR had V10, L28, E120, D122, and D127 containing disordered side chains.   PDB ID 6DFR had the side chains beyond the CB of E120 and D127 being disordered.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000792
name: dihydrofolate reductase region 6
namespace: region
def: "." [DPO:curators, PMID:9012674, PMID:14717591]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000793
name: dihydrofolate reductase region 7
namespace: region
def: "." [DPO:curators, PMID:9012674, PMID:14717591]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000794
name: putative stringent starvation protein A region 1
namespace: region
def: "." [DPO:curators, PMID:15735307]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)

[Term]
id: DPO:000795
name: putative stringent starvation protein A region 2
namespace: region
def: "." [DPO:curators, PMID:15735307]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000796
name: putative stringent starvation protein A region 3
namespace: region
def: "." [DPO:curators, PMID:15735307]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)

[Term]
id: DPO:000797
name: myoglobin region 1
namespace: region
def: "." [DPO:curators, PMID:8844864, PMID:12079388]
comment: This region becomes disordered between a pressure change of 500 and 1200 bar. 
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000798
name: myoglobin region 2
namespace: region
def: "." [DPO:curators, PMID:8844864, PMID:12079388]
comment: This region becomes disordered between a pressure change of 500 and 1200 bar. 
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000799
name: myoglobin region 3
namespace: region
def: "." [DPO:curators, PMID:8844864, PMID:12079388]
comment: This region is the only disordered region for the natively folded protein when at a pressure of 30 bar.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000800
name: myoglobin region 4
namespace: region
def: "." [DPO:curators, PMID:12079388, PMID:8844864]
comment: This region becomes disordered between a pressure change of 500 and 1200 bar. 
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000801
name: myoglobin region 5
namespace: region
def: "." [DPO:curators, PMID:12079388, PMID:8844864]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000802
name: myoglobin region 6
namespace: region
def: "." [DPO:curators, PMID:12079388, PMID:8844864]
comment: This region becomes disordered between a pressure change of 500 and 1200 bar. 
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000803
name: myoglobin region 7
namespace: region
def: "." [DPO:curators, PMID:12079388, PMID:8844864]
comment: The entire protein forms into a molten globule conformation at a pressure of 2000 bar.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000804
name: myoglobin region 8
namespace: region
def: "." [DPO:curators, PMID:12079388, PMID:8844864]
comment: The entire protein forms into an extended, disordered conformation at a pressure of 3000 bar.
is_a: DPO:000008 ! disordered - extended region

[Term]
id: DPO:000805
name: RAC-beta serine/threonine-protein kinase region 1
namespace: region
def: "." [DPO:curators, PMID:12086620]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003912 ! RAC-beta serine/threonine-protein kinase

[Term]
id: DPO:000806
name: RAC-beta serine/threonine-protein kinase region 2
namespace: region
def: "." [DPO:curators, PMID:12086620]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003912 ! RAC-beta serine/threonine-protein kinase

[Term]
id: DPO:000807
name: RAC-beta serine/threonine-protein kinase region 3
namespace: region
def: "." [DPO:curators, PMID:12086620]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003912 ! RAC-beta serine/threonine-protein kinase

[Term]
id: DPO:000808
name: RAC-beta serine/threonine-protein kinase region 4
namespace: region
def: "." [DPO:curators, PMID:12086620]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003912 ! RAC-beta serine/threonine-protein kinase

[Term]
id: DPO:000809
name: RAC-beta serine/threonine-protein kinase region 5
namespace: region
def: "." [DPO:curators, PMID:12517337]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003912 ! RAC-beta serine/threonine-protein kinase

[Term]
id: DPO:000810
name: RAC-beta serine/threonine-protein kinase region 6
namespace: region
def: "." [DPO:curators, PMID:12517337]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003912 ! RAC-beta serine/threonine-protein kinase

[Term]
id: DPO:000811
name: RAC-beta serine/threonine-protein kinase region 7
namespace: region
def: "." [DPO:curators, PMID:12517337]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003912 ! RAC-beta serine/threonine-protein kinase

[Term]
id: DPO:000812
name: RAC-beta serine/threonine-protein kinase region 8
namespace: region
def: "." [DPO:curators, PMID:12517337]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003912 ! RAC-beta serine/threonine-protein kinase

[Term]
id: DPO:000813
name: RAC-beta serine/threonine-protein kinase region 9
namespace: region
def: "." [DPO:curators, PMID:12517337]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003912 ! RAC-beta serine/threonine-protein kinase

[Term]
id: DPO:000814
name: RAC-beta serine/threonine-protein kinase region 10
namespace: region
def: "." [DPO:curators, PMID:12517337]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003912 ! RAC-beta serine/threonine-protein kinase

[Term]
id: DPO:000815
name: RAC-beta serine/threonine-protein kinase region 11
namespace: region
def: "." [DPO:curators, PMID:12517337]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003912 ! RAC-beta serine/threonine-protein kinase

[Term]
id: DPO:000816
name: carnitine O-acetyltransferase [Isoform 1] region 1
namespace: region
def: "." [DPO:curators, PMID:12562770]
comment: The PDB file has an additional sequence of missing residues at the C terminus of this disordered region.  It consists of the following residues: ISEEDLSLISG.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000817
name: early activation antigen CD69 region 1
namespace: region
def: "." [DPO:curators, PMID:11101293]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000001343 ! early activation antigen CD69

[Term]
id: DPO:000818
name: cyclin-H region 1
namespace: region
def: "." [DPO:curators, PMID:8941715]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000005130 ! cyclin-H

[Term]
id: DPO:000819
name: cyclin-H region 2
namespace: region
def: "." [DPO:curators, PMID:8941715]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000005130 ! cyclin-H

[Term]
id: DPO:000820
name: uroporphyrinogen decarboxylase region 1
namespace: region
def: "." [DPO:curators, PMID:11719352]
comment: This disordered region contains the first 9 amino acids of the SwissProt sequence, and does not include the N-terminal tag as found in the PDB file and both references.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000017134 ! uroporphyrinogen decarboxylase

[Term]
id: DPO:000821
name: uroporphyrinogen decarboxylase region 2
namespace: region
def: "." [DPO:curators, PMID:11719352, PMID:9564029]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000017134 ! uroporphyrinogen decarboxylase

[Term]
id: DPO:000822
name: uroporphyrinogen decarboxylase region 4
namespace: region
def: "." [DPO:curators, PMID:9564029]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000017134 ! uroporphyrinogen decarboxylase

[Term]
id: DPO:000823
name: epidermal growth factor receptor [Isoform 1] region 1
namespace: region
def: "." [DPO:curators, PMID:12196540]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000824
name: epidermal growth factor receptor [Isoform 1] region 2
namespace: region
def: "." [DPO:curators, PMID:12196540]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000825
name: epidermal growth factor receptor [Isoform 1] region 3
namespace: region
def: "." [DPO:curators, PMID:12196540]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000826
name: eukaryotic peptide chain release factor subunit 1 region 1
namespace: region
def: "." [DPO:curators, PMID:10676813]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000007214 ! eukaryotic peptide chain release factor subunit 1

[Term]
id: DPO:000827
name: eukaryotic peptide chain release factor subunit 1 region 2
namespace: region
def: "." [DPO:curators, PMID:10676813]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000007214 ! eukaryotic peptide chain release factor subunit 1

[Term]
id: DPO:000828
name: eukaryotic peptide chain release factor subunit 1 region 3
namespace: region
def: "." [DPO:curators, PMID:10676813]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000007214 ! eukaryotic peptide chain release factor subunit 1

[Term]
id: DPO:000829
name: eukaryotic peptide chain release factor subunit 1 region 4
namespace: region
def: "." [DPO:curators, PMID:10676813]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000007214 ! eukaryotic peptide chain release factor subunit 1

[Term]
id: DPO:000830
name: immunoglobulin alpha Fc receptor [Isoform A.1] region 1
namespace: region
def: "." [DPO:curators, PMID:12783876]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000831
name: immunoglobulin alpha Fc receptor [Isoform A.1] region 2
namespace: region
def: "." [DPO:curators, PMID:12783876]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000832
name: immunoglobulin alpha Fc receptor [Isoform A.1] region 3
namespace: region
def: "." [DPO:curators, PMID:12783876]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000833
name: FL cytokine receptor region 1
namespace: region
def: "." [DPO:curators, PMID:14759363]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000002001 ! FL cytokine receptor

[Term]
id: DPO:000834
name: FL cytokine receptor region 2
namespace: region
def: "." [DPO:curators, PMID:14759363]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000002001 ! FL cytokine receptor

[Term]
id: DPO:000835
name: FL cytokine receptor region 3
namespace: region
def: "." [DPO:curators, PMID:14759363]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000002001 ! FL cytokine receptor

[Term]
id: DPO:000836
name: FL cytokine receptor region 4
namespace: region
def: "." [DPO:curators, PMID:14759363]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000002001 ! FL cytokine receptor

[Term]
id: DPO:000837
name: interferon-induced guanylate-binding protein 1 region 1
namespace: region
def: "." [DPO:curators, PMID:10676968]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000007874 ! interferon-induced guanylate-binding protein 1

[Term]
id: DPO:000838
name: interferon-induced guanylate-binding protein 1 region 2
namespace: region
def: "." [DPO:curators, PMID:10676968]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000007874 ! interferon-induced guanylate-binding protein 1

[Term]
id: DPO:000839
name: interferon-induced guanylate-binding protein 1 region 3
namespace: region
def: "." [DPO:curators, PMID:10676968]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000007874 ! interferon-induced guanylate-binding protein 1

[Term]
id: DPO:000840
name: interferon-induced guanylate-binding protein 1 region 4
namespace: region
def: "." [DPO:curators, PMID:10676968]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000007874 ! interferon-induced guanylate-binding protein 1

[Term]
id: DPO:000841
name: interferon-induced guanylate-binding protein 1 region 5
namespace: region
def: "." [DPO:curators, PMID:10676968]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000007874 ! interferon-induced guanylate-binding protein 1

[Term]
id: DPO:000842
name: interferon-induced guanylate-binding protein 1 region 6
namespace: region
def: "." [DPO:curators, PMID:10676968]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000007874 ! interferon-induced guanylate-binding protein 1

[Term]
id: DPO:000843
name: ADP-ribosylation factor-binding protein GGA1 [Isoform 1] region 1
namespace: region
def: "." [DPO:curators, PMID:12668765]
comment: The PDB file contains an additional 5 amino acid insert consisting of GAMGS at the N-terminus of this region.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000844
name: ADP-ribosylation factor-binding protein GGA1 [Isoform 1] region 2
namespace: region
def: "." [DPO:curators, PMID:12668765]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000845
name: ADP-ribosylation factor-binding protein GGA1 [Isoform 1] region 3
namespace: region
def: "." [DPO:curators, PMID:12668765]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000846
name: ADP-ribosylation factor-binding protein GGA1 [Isoform 1] region 4
namespace: region
def: "." [DPO:curators, PMID:12679809]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000847
name: ADP-ribosylation factor-binding protein GGA1 [Isoform 1] region 5
namespace: region
def: "." [DPO:curators, PMID:12679809]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000848
name: ADP-ribosylation factor-binding protein GGA1 [Isoform 1] region 6
namespace: region
def: "." [DPO:curators, PMID:12767220]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000849
name: ADP-ribosylation factor-binding protein GGA1 [Isoform 1] region 7
namespace: region
def: "." [DPO:curators, PMID:12767220]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000850
name: serine protease HTRA2, mitochondrial [Isoform 1 (13B)] region 1
namespace: region
def: "." [DPO:curators, PMID:11967569]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000851
name: serine protease HTRA2, mitochondrial [Isoform 1 (13B)] region 2
namespace: region
def: "." [DPO:curators, PMID:11967569]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000852
name: serine protease HTRA2, mitochondrial [Isoform 1 (13B)] region 3
namespace: region
def: "." [DPO:curators, PMID:11967569]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000853
name: hepatocyte growth factor receptor [Isoform 1] region 1
namespace: region
def: "." [DPO:curators, PMID:14559966]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000854
name: hepatocyte growth factor receptor [Isoform 1] region 2
namespace: region
def: "." [DPO:curators, PMID:14559966]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000855
name: hepatocyte growth factor receptor [Isoform 1] region 3
namespace: region
def: "." [DPO:curators, PMID:14559966]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000856
name: hepatocyte growth factor receptor [Isoform 1] region 4
namespace: region
def: "." [DPO:curators, PMID:14559966]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000857
name: hepatocyte growth factor receptor [Isoform 1] region 5
namespace: region
def: "." [DPO:curators, PMID:15167892]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000858
name: hepatocyte growth factor receptor [Isoform 1] region 6
namespace: region
def: "." [DPO:curators, PMID:15167892]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000859
name: hepatocyte growth factor receptor [Isoform 1] region 7
namespace: region
def: "." [DPO:curators, PMID:15167892]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000860
name: hepatocyte growth factor receptor [Isoform 1] region 8
namespace: region
def: "." [DPO:curators, PMID:15167892]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000861
name: hepatocyte growth factor receptor [Isoform 1] region 9
namespace: region
def: "." [DPO:curators, PMID:15167892]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000862
name: nuclear pore complex protein Nup133 region 1
namespace: region
def: "." [DPO:curators, PMID:15557116]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000011507 ! nuclear pore complex protein Nup133

[Term]
id: DPO:000863
name: nuclear pore complex protein Nup133 region 2
namespace: region
def: "." [DPO:curators, PMID:15557116]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000011507 ! nuclear pore complex protein Nup133

[Term]
id: DPO:000864
name: nuclear pore complex protein Nup133 region 3
namespace: region
def: "." [DPO:curators, PMID:15557116]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000011507 ! nuclear pore complex protein Nup133

[Term]
id: DPO:000865
name: nuclear pore complex protein Nup133 region 4
namespace: region
def: "." [DPO:curators, PMID:15557116]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000011507 ! nuclear pore complex protein Nup133

[Term]
id: DPO:000866
name: nuclear pore complex protein Nup133 region 5
namespace: region
def: "." [DPO:curators, PMID:15557116]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000011507 ! nuclear pore complex protein Nup133

[Term]
id: DPO:000867
name: tumor protein p73 [Isoform Alpha] region 1
namespace: region
def: "." [DPO:curators, PMID:11264583]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000868
name: tumor protein p73 [Isoform Alpha] region 2
namespace: region
def: "." [DPO:curators, PMID:11264583]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000869
name: plasminogen activator inhibitor 1 region 1
namespace: region
def: "." [DPO:curators, PMID:7664104]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000014702 ! plasminogen activator inhibitor 1

[Term]
id: DPO:000870
name: protein-arginine deiminase type-4 region 1
namespace: region
def: "." [DPO:curators, PMID:15247907]
comment: According to the PDB fle, this region had an additional 7 amino acid tag on the N-terminal end consisting of GPLGSPQ.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012222 ! protein-arginine deiminase type-4

[Term]
id: DPO:000871
name: protein-arginine deiminase type-4 region 2
namespace: region
def: "." [DPO:curators, PMID:15247907]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012222 ! protein-arginine deiminase type-4

[Term]
id: DPO:000872
name: protein-arginine deiminase type-4 region 3
namespace: region
def: "." [DPO:curators, PMID:15247907]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012222 ! protein-arginine deiminase type-4

[Term]
id: DPO:000873
name: protein-arginine deiminase type-4 region 4
namespace: region
def: "." [DPO:curators, PMID:15247907]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012222 ! protein-arginine deiminase type-4

[Term]
id: DPO:000874
name: protein-arginine deiminase type-4 region 5
namespace: region
def: "." [DPO:curators, PMID:15247907]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012222 ! protein-arginine deiminase type-4

[Term]
id: DPO:000875
name: protein-arginine deiminase type-4 region 6
namespace: region
def: "." [DPO:curators, PMID:15247907]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012222 ! protein-arginine deiminase type-4

[Term]
id: DPO:000876
name: protein-arginine deiminase type-4 region 7
namespace: region
def: "." [DPO:curators, PMID:15247907]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012222 ! protein-arginine deiminase type-4

[Term]
id: DPO:000877
name: protein-arginine deiminase type-4 region 8
namespace: region
def: "." [DPO:curators, PMID:15247907]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012222 ! protein-arginine deiminase type-4

[Term]
id: DPO:000878
name: protein-arginine deiminase type-4 region 9
namespace: region
def: "." [DPO:curators, PMID:15247907]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012222 ! protein-arginine deiminase type-4

[Term]
id: DPO:000879
name: protein-arginine deiminase type-4 region 10
namespace: region
def: "." [DPO:curators, PMID:15247907]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012222 ! protein-arginine deiminase type-4

[Term]
id: DPO:000880
name: proto-oncogene serine/threonine-protein kinase Pim-1 [Isoform 2] region 1
namespace: region
def: "." [DPO:curators, PMID:15525646]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000881
name: proto-oncogene serine/threonine-protein kinase Pim-1 [Isoform 2] region 2
namespace: region
def: "." [DPO:curators, PMID:15525646]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000882
name: nuclear receptor subfamily 1 group I member 2 [Isoform 1A (1)(PRR1-A)] region 1
namespace: region
def: "." [DPO:curators, PMID:11408620]
comment: There is an additional 11 amino acids in the disordered region based upon the PDB sequence.  The sequence is as follows: MKKGHHHHHHG.  It is located from residue 119 to 129.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000883
name: nuclear receptor subfamily 1 group I member 2 [Isoform 1A (1)(PRR1-A)] region 2
namespace: region
def: "." [DPO:curators, PMID:11408620]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000884
name: nuclear receptor subfamily 1 group I member 2 [Isoform 1A (1)(PRR1-A)] region 3
namespace: region
def: "." [DPO:curators, PMID:11408620]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000885
name: heterogeneous nuclear ribonucleoprotein A1 [Isoform A1-B] region 1
namespace: region
def: "." [DPO:curators, PMID:11917013]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000886
name: heterogeneous nuclear ribonucleoprotein A1 [Isoform A1-B] region 2
namespace: region
def: "." [DPO:curators, PMID:11917013]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000887
name: heterogeneous nuclear ribonucleoprotein A1 [Isoform A1-B] region 3
namespace: region
def: "." [DPO:curators, PMID:11917013]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000888
name: protein phosphatase 1 regulatory subunit 1A region 1
namespace: region
def: "." [DPO:curators, PMID:208844]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000889
name: DNA ligase region 1
namespace: region
def: "." [DPO:curators, PMID:15296738]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000890
name: phytanoyl-CoA dioxygenase, peroxisomal region 1
namespace: region
def: "." [DPO:curators, PMID:16186124]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012674 ! phytanoyl-CoA dioxygenase, peroxisomal

[Term]
id: DPO:000891
name: phytanoyl-CoA dioxygenase, peroxisomal region 2
namespace: region
def: "." [DPO:curators, PMID:16186124]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012674 ! phytanoyl-CoA dioxygenase, peroxisomal

[Term]
id: DPO:000892
name: phytanoyl-CoA dioxygenase, peroxisomal region 3
namespace: region
def: "." [DPO:curators, PMID:16186124]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012674 ! phytanoyl-CoA dioxygenase, peroxisomal
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000893
name: phytanoyl-CoA dioxygenase, peroxisomal region 4
namespace: region
def: "." [DPO:curators, PMID:16186124]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012674 ! phytanoyl-CoA dioxygenase, peroxisomal
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000894
name: phytanoyl-CoA dioxygenase, peroxisomal region 5
namespace: region
def: "." [DPO:curators, PMID:16186124]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012674 ! phytanoyl-CoA dioxygenase, peroxisomal
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000895
name: transcription factor GAGA [Isoform B] region 1
namespace: region
def: "." [DPO:curators, PMID:9878427]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000896
name: transcription factor GAGA [Isoform B] region 2
namespace: region
def: "." [DPO:curators, PMID:9878427]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding

[Term]
id: DPO:000897
name: transcription factor GAGA [Isoform B] region 3
namespace: region
def: "." [DPO:curators, PMID:9878427]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding

[Term]
id: DPO:000898
name: beta-casein region 1
namespace: region
def: "." [DPO:curators, PMID:8373815]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000899
name: beta-casein region 2
namespace: region
def: "." [DPO:curators, PMID:7305393]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000900
name: alpha-S1-casein region 1
namespace: region
def: "." [DPO:curators, PMID:7305393]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000901
name: bone sialoprotein 2 region 1
namespace: region
def: "." [DPO:curators, PMID:11162539]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000008878 ! bone sialoprotein 2
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000902
name: calreticulin region 1
namespace: region
def: "." [DPO:curators, PMID:11101311]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000004984 ! calreticulin

[Term]
id: DPO:000903
name: calreticulin region 2
namespace: region
def: "." [DPO:curators, PMID:11101311]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000004984 ! calreticulin

[Term]
id: DPO:000904
name: E3 ubiquitin-protein ligase Mdm2 [Isoform Mdm2] region 1
namespace: region
def: "." [DPO:curators, PMID:11718560]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000905
name: E3 ubiquitin-protein ligase Mdm2 [Isoform Mdm2] region 2
namespace: region
def: "." [DPO:curators, PMID:12630860]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000906
name: E3 ubiquitin-protein ligase Mdm2 [Isoform Mdm2] region 3
namespace: region
def: "." [DPO:curators, PMID:15953616]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000907
name: cyclin-dependent kinase inhibitor 2A [Isoform 3] region 1
namespace: region
def: "." [DPO:curators, PMID:11718560]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000908
name: cyclin-dependent kinase inhibitor 2A [Isoform 4] region 1
namespace: region
def: "." [DPO:curators, PMID:11718560, PMID:12630860]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000909
name: deoxyuridine 5'-triphosphate nucleotidohydrolase region 1
namespace: region
def: "." [DPO:curators, PMID:1311056]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022493 ! deoxyuridine 5'-triphosphate nucleotidohydrolase

[Term]
id: DPO:000910
name: deoxyuridine 5'-triphosphate nucleotidohydrolase region 2
namespace: region
def: "." [DPO:curators, PMID:11257499]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022493 ! deoxyuridine 5'-triphosphate nucleotidohydrolase

[Term]
id: DPO:000911
name: histo-blood group B transferase region 1
namespace: region
def: "." [DPO:curators, PMID:15987364]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000912
name: histo-blood group B transferase region 2
namespace: region
def: "." [DPO:curators, PMID:15987364]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000913
name: histo-blood group A transferase region 1
namespace: region
def: "." [DPO:curators, PMID:15987364]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003587 ! histo-blood group ABO system transferase

[Term]
id: DPO:000914
name: histo-blood group A transferase region 2
namespace: region
def: "." [DPO:curators, PMID:15987364]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003587 ! histo-blood group ABO system transferase

[Term]
id: DPO:000915
name: catenin beta-1 region 1
namespace: region
def: "." [DPO:curators, PMID:9298899]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000002198 ! catenin beta-1

[Term]
id: DPO:000916
name: catenin beta-1 region 2
namespace: region
def: "." [DPO:curators, PMID:9298899]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000002198 ! catenin beta-1

[Term]
id: DPO:000917
name: catenin beta-1 region 3
namespace: region
def: "." [DPO:curators, PMID:9298899]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000002198 ! catenin beta-1

[Term]
id: DPO:000918
name: catenin beta-1 region 4
namespace: region
def: "." [DPO:curators, PMID:15629534]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000002198 ! catenin beta-1
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000919
name: colicin-E9 region 1
namespace: region
def: "." [DPO:curators, PMID:12054823]
comment: N-terminus responsible for translocation of the cytotoxic domain into the target cell.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000920
name: nuclear receptor coactivator 3 [Isoform 3, variant] region 1
namespace: region
def: "." [DPO:curators, PMID:11823864]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000921
name: nuclear receptor coactivator 3 [Isoform 3, variant] region 2
namespace: region
def: "." [DPO:curators, PMID:11823864]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000922
name: nuclear receptor coactivator 3 [Isoform 3, variant] region 3
namespace: region
def: "." [DPO:curators, PMID:11823864]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000923
name: leukotoxin region 1
namespace: region
def: "." [DPO:curators, PMID:7703231]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000924
name: retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma region 1
namespace: region
def: "." [DPO:curators, PMID:12643535]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000925
name: CREB-binding protein region 1
namespace: region
def: "." [DPO:curators, PMID:11823864]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000000090 ! creb-binding protein
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000926
name: CREB-binding protein region 2
namespace: region
def: "." [DPO:curators, PMID:11583620]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000000090 ! creb-binding protein
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000059 ! order to disorder transition

[Term]
id: DPO:000927
name: CREB-binding protein region 3
namespace: region
def: "." [DPO:curators, PMID:11823864]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000000090 ! creb-binding protein

[Term]
id: DPO:000928
name: bifunctional protein birA region 1
namespace: region
def: "." [DPO:curators, PMID:11124029]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022227 ! bifunctional protein birA
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000929
name: bifunctional protein birA region 2
namespace: region
def: "." [DPO:curators, PMID:1409631]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022227 ! bifunctional protein birA
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000930
name: bifunctional protein birA region 3
namespace: region
def: "." [DPO:curators, PMID:10497026]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022227 ! bifunctional protein birA
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000931
name: bifunctional protein birA region 4
namespace: region
def: "." [DPO:curators, PMID:11124029]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022227 ! bifunctional protein birA
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000932
name: bifunctional protein birA region 5
namespace: region
def: "." [DPO:curators, PMID:10497026]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022227 ! bifunctional protein birA
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000933
name: bifunctional protein birA region 6
namespace: region
def: "." [DPO:curators, PMID:11124029]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022227 ! bifunctional protein birA
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000934
name: bifunctional protein birA region 7
namespace: region
def: "." [DPO:curators, PMID:10497026]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022227 ! bifunctional protein birA
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000935
name: bifunctional protein birA region 8
namespace: region
def: "." [DPO:curators, PMID:1409631]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022227 ! bifunctional protein birA

[Term]
id: DPO:000936
name: chemotaxis protein cheW region 1
namespace: region
def: "." [DPO:curators, PMID:11799399]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000937
name: chemotaxis protein cheW region 2
namespace: region
def: "." [DPO:curators, PMID:11799399]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000938
name: chemotaxis protein cheW region 3
namespace: region
def: "." [DPO:curators, PMID:11799399]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000939
name: chemotaxis protein cheW region 4
namespace: region
def: "." [DPO:curators, PMID:11799399]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000940
name: chemotaxis protein cheW region 5
namespace: region
def: "." [DPO:curators, PMID:11799399, PMID:12488014]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000941
name: chemotaxis protein cheW region 6
namespace: region
def: "." [DPO:curators, PMID:11799399, PMID:12488014]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000942
name: chemotaxis protein cheW region 7
namespace: region
def: "." [DPO:curators, PMID:12488014]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000943
name: putative tyrosine-protein phosphatase auxilin region 1
namespace: region
def: "." [DPO:curators, PMID:12732633]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000944
name: glycyl-glycine endopeptidase lytM region 1
namespace: region
def: "." [DPO:curators, PMID:16269153]
comment: The fragment used to determine the crystal structure consisted of residues 185-316.
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000034 ! metal binding

[Term]
id: DPO:000945
name: glycyl-glycine endopeptidase lytM region 2
namespace: region
def: "." [DPO:curators, PMID:16269153]
comment: The fragment used to determine the crystal structure consisted of residues 185-316.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000946
name: glycyl-glycine endopeptidase lytM region 3
namespace: region
def: "." [DPO:curators, PMID:16269153]
comment: The fragment used to determine the crystal structure consisted of residues 185-316.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000947
name: glycyl-glycine endopeptidase lytM region 4
namespace: region
def: "." [DPO:curators, PMID:16269153]
comment: The fragment used to determine the crystal structure consisted of residues 185-316.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000948
name: protein URE2 region 1
namespace: region
def: "." [DPO:curators, PMID:10224139, PMID:11327838, PMID:15628874]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000038 ! polymerization
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000949
name: fibronectin binding protein region 1
namespace: region
def: "." [DPO:curators, PMID:15292204]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000950
name: apolipoprotein E region 1
namespace: region
def: "." [DPO:curators, PMID:10850798, PMID:2063194]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000004155 ! apolipoprotein E

[Term]
id: DPO:000951
name: apolipoprotein E region 2
namespace: region
def: "." [DPO:curators, PMID:10850798, PMID:2063194]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000004155 ! apolipoprotein E
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000042 ! protein-lipid interaction
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000952
name: apolipoprotein E region 3
namespace: region
def: "." [DPO:curators, PMID:10850798, PMID:2063194]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000004155 ! apolipoprotein E

[Term]
id: DPO:000953
name: Cbp/p300-interacting transactivator 2 [Isoform 1] region 1
namespace: region
def: "." [DPO:curators, PMID:14594809]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000954
name: thymosin beta-4 region 1
namespace: region
def: "." [DPO:curators, PMID:15039431, PMID:8269922]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000016463 ! thymosin beta-4
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000038 ! polymerization
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000955
name: prostaglandin E synthase 3 region 1
namespace: region
def: "." [DPO:curators, PMID:10543959]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000013423 ! prostaglandin E synthase 3
relationship: has_function DPO:000011 ! chaperone
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000059 ! order to disorder transition

[Term]
id: DPO:000956
name: prostaglandin E synthase 3 region 2
namespace: region
def: "." [DPO:curators, PMID:10811660]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000013423 ! prostaglandin E synthase 3
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000957
name: calvin cycle protein CP12 region 1
namespace: region
def: "." [DPO:curators, PMID:12846565, PMID:16259044, PMID:16427344]
comment: The presence of copper cations catalyzes the re-formation of disulfide bonds in the reduced form of this protein.  This in turn leads to the formation of the oxidized CP12, which can then bind a copper ion.  
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000017 ! molecular recognition scavenger
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000958
name: calvin cycle protein CP12 region 2
namespace: region
def: "." [DPO:curators, PMID:16259044, PMID:16427344, PMID:12846565]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000959
name: calvin cycle protein CP12 region 3
namespace: region
def: "." [DPO:curators, PMID:12846565, PMID:16259044, PMID:16427344]
is_a: DPO:000010 ! disordered - molten globule region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000960
name: cytoplasmic dynein 1 intermediate chain 1 [Isoform 1] region 1
namespace: region
def: "." [DPO:curators, PMID:15581372, PMID:11914076, PMID:15051340]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000961
name: XO lethal protein 1 [Isoform b] region 1
namespace: region
def: "." [DPO:curators, PMID:12672694]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000962
name: XO lethal protein 1 [Isoform b] region 2
namespace: region
def: "." [DPO:curators, PMID:12672694]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000963
name: XO lethal protein 1 [Isoform b] region 3
namespace: region
def: "." [DPO:curators, PMID:12672694]
comment: Electron density was not visible for residues 190-195 in monomer 1, and residues 190-194 in monomer 2.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000964
name: UDP-N-acetylhexosamine pyrophosphorylase [Isoform AGX1] region 1
namespace: region
def: "." [DPO:curators, PMID:11707391]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000965
name: GTP-binding protein Rheb region 1
namespace: region
def: "." [DPO:curators, PMID:15728574]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000013975 ! GTP-binding protein Rheb
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000966
name: serine/threonine protein phosphatase 5 region 1
namespace: region
def: "." [DPO:curators, PMID:15713458]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000013157 ! serine/threonine-protein phosphatase 5
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000058 ! molten globule to order transition

[Term]
id: DPO:000967
name: urease accessory protein UreG region 1
namespace: region
def: "." [DPO:curators, PMID:15542602]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000011 ! chaperone
relationship: has_subfunction DPO:000022 ! cofactor/heme binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000968
name: uncharacterized protein C8orf4 region 1
namespace: region
def: "." [DPO:curators, PMID:15087392]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000969
name: penaeidin-3a region 1
namespace: region
def: "." [DPO:curators, PMID:12842879]
comment: The SwissProt sequence contained an additional 19 amino acids at the N-terminus of this protein that were not used in the Yang et al. paper.  
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000970
name: diphtheria toxin repressor region 1
namespace: region
def: "." [DPO:curators, PMID:10339551]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000971
name: ProP effector region 1
namespace: region
def: "." [DPO:curators, PMID:15476391]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023600 ! proP effector
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000972
name: methane monooxygenase component C region 1
namespace: region
def: "." [DPO:curators, PMID:15379538]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:000973
name: methane monooxygenase component C region 2
namespace: region
def: "." [DPO:curators, PMID:15379538]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000974
name: methane monooxygenase component C region 3
namespace: region
def: "." [DPO:curators, PMID:15379538]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000975
name: putative carnobacteriocin-B2 immunity protein region 1
namespace: region
def: "." [DPO:curators, PMID:15362858]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000976
name: aryl hydrocarbon receptor region 1
namespace: region
def: "." [DPO:curators, PMID:15641800]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003858 ! aryl hydrocarbon receptor
relationship: has_function DPO:000014 ! modification site
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000977
name: ribonuclease P protein component 1 region 1
namespace: region
def: "." [DPO:curators, PMID:15518563]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000978
name: ribonuclease P protein component 1 region 2
namespace: region
def: "." [DPO:curators, PMID:15518563]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000979
name: aldehyde dehydrogenase, mitochondrial region 1
namespace: region
def: "." [DPO:curators, PMID:15983043]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003925 ! aldehyde dehydrogenase, mitochondrial

[Term]
id: DPO:000980
name: aldehyde dehydrogenase, mitochondrial region 2
namespace: region
def: "." [DPO:curators, PMID:15983043]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003925 ! aldehyde dehydrogenase, mitochondrial

[Term]
id: DPO:000981
name: aldehyde dehydrogenase, mitochondrial region 3
namespace: region
def: "." [DPO:curators, PMID:15983043]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003925 ! aldehyde dehydrogenase, mitochondrial

[Term]
id: DPO:000982
name: glycogen synthase kinase-3 beta [Isoform 1] region 1
namespace: region
def: "." [DPO:curators, PMID:11440715]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000021 ! autoregulatory

[Term]
id: DPO:000983
name: glycogen synthase kinase-3 beta [Isoform 1] region 2
namespace: region
def: "." [DPO:curators, PMID:11440715]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000984
name: glycogen synthase kinase-3 beta [Isoform 1] region 3
namespace: region
def: "." [DPO:curators, PMID:12554650]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000985
name: glycogen synthase kinase-3 beta [Isoform 1] region 4
namespace: region
def: "." [DPO:curators, PMID:11427888]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000986
name: ribonuclease P protein component region 1
namespace: region
def: "." [DPO:curators, PMID:11258888, PMID:16185070]
comment: RNase P is predominantly unfolded when isolated from RNA and small molecule anions in a low-ionic strength buffer. The P protein can be induced to refold by increasing the anion concentration in solution or by the addition of the osmolyte trimethylamine N-oxide (TMAO).
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000041 ! protein-genomic RNA binding
relationship: has_structural_basis_for_function DPO:000052 ! ordered state

[Term]
id: DPO:000987
name: hemolysin, chromosomal region 1
namespace: region
def: "." [DPO:curators, PMID:7703231]
comment: The 61 bp C-terminus disordered region published in the Zhang paper contains discrepancies when compared to the SwisProt sequence. The SwisProt sequence at regions 964, 965, 970 and 996 are L, A, G, A, compared to the disorder paper sequence of S, T, D, S respectively.
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000988
name: beta-arrestin-1 [Isoform 1A] region 1
namespace: region
def: "." [DPO:curators, PMID:11566136]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000989
name: beta-arrestin-1 [Isoform 1A] region 3
namespace: region
def: "." [DPO:curators, PMID:11566136]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:000990
name: nuclear cap-binding protein subunit 1 region 1
namespace: region
def: "." [DPO:curators, PMID:11545740]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000011026 ! nuclear cap-binding protein subunit 1

[Term]
id: DPO:000991
name: nuclear cap-binding protein subunit 1 region 2
namespace: region
def: "." [DPO:curators, PMID:11545740]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000011026 ! nuclear cap-binding protein subunit 1

[Term]
id: DPO:000992
name: nuclear cap-binding protein subunit 1 region 3
namespace: region
def: "." [DPO:curators, PMID:11545740]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000011026 ! nuclear cap-binding protein subunit 1

[Term]
id: DPO:000993
name: nuclear cap-binding protein subunit 1 region 4
namespace: region
def: "." [DPO:curators, PMID:11545740]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000011026 ! nuclear cap-binding protein subunit 1

[Term]
id: DPO:000994
name: nuclear cap-binding protein subunit 1 region 5
namespace: region
def: "." [DPO:curators, PMID:11545740]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000011026 ! nuclear cap-binding protein subunit 1

[Term]
id: DPO:000995
name: nuclear cap-binding protein subunit 1 region 6
namespace: region
def: "." [DPO:curators, PMID:11545740]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000011026 ! nuclear cap-binding protein subunit 1

[Term]
id: DPO:000996
name: nuclear cap-binding protein subunit 2 [Isoform 1] region 1
namespace: region
def: "." [DPO:curators, PMID:11545740]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000041 ! protein-genomic RNA binding

[Term]
id: DPO:000997
name: nuclear cap-binding protein subunit 2 [Isoform 1] region 2
namespace: region
def: "." [DPO:curators, PMID:11545740]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000041 ! protein-genomic RNA binding
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:000998
name: nuclear cap-binding protein subunit 2 [Isoform 1] region 3
namespace: region
def: "." [DPO:curators, PMID:11545740]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:000999
name: nuclear cap-binding protein subunit 2 [Isoform 1] region 4
namespace: region
def: "." [DPO:curators, PMID:11545740]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001000
name: nuclear cap-binding protein subunit 2 [Isoform 1] region 5
namespace: region
def: "." [DPO:curators, PMID:11545740]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000041 ! protein-genomic RNA binding

[Term]
id: DPO:001001
name: nuclear cap-binding protein subunit 2 [Isoform 1] region 6
namespace: region
def: "." [DPO:curators, PMID:11545740]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000041 ! protein-genomic RNA binding

[Term]
id: DPO:001002
name: subtilisin E region 1
namespace: region
def: "." [DPO:curators, PMID:11519747]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000011 ! chaperone
relationship: has_subfunction DPO:000021 ! autoregulatory
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001003
name: calmodulin-sensitive adenylate cyclase region 1
namespace: region
def: "." [DPO:curators, PMID:11807546]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001004
name: eukaryotic peptide chain release factor GTP-binding subunit region 1
namespace: region
def: "." [DPO:curators, PMID:15099522]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001005
name: eukaryotic peptide chain release factor GTP-binding subunit region 2
namespace: region
def: "." [DPO:curators, PMID:15099522]
comment: Disordered region 2 is contained within Switch I of the protein.
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001006
name: eukaryotic peptide chain release factor GTP-binding subunit region 3
namespace: region
def: "." [DPO:curators, PMID:15099522]
comment: The fragment used for structure determination consisted of residues 196-662. Disordered region 3 is contained within Switch II of the protein.
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001007
name: exostosin-like 2 region 1
namespace: region
def: "." [DPO:curators, PMID:12562774]
comment: The fragment used to determine the crystal structure consisted of residues 63-327.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000007271 ! exostosin-like 2
relationship: has_function DPO:000014 ! modification site
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001008
name: acetolactate synthase catalytic subunit, mitochondrial region 1
namespace: region
def: "." [DPO:curators, PMID:11902841]
comment: The mature protein, consisting of residues 58-687, was used for crystal structure determination.  A 47 residue N-terminal peptide containing a hexahistidine tag was added. This region was disordered in monomer A.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001009
name: acetolactate synthase catalytic subunit, mitochondrial region 2
namespace: region
def: "." [DPO:curators, PMID:11902841]
comment: The mature protein, consisting of residues 58-687, was used for crystal structure determination. A 47 residue N-terminal peptide containing a hexahistidine tag was added. This region was disordered in monomer A.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001010
name: acetolactate synthase catalytic subunit, mitochondrial region 3
namespace: region
def: "." [DPO:curators, PMID:11902841]
comment: The mature protein, consisting of residues 58-687, was used for crystal structure determination. A 47 residue N-terminal peptide containing a hexahistidine tag was added. This region was traceable in monomer B, but completely disordered in monomer A.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000021 ! autoregulatory
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001011
name: acetolactate synthase catalytic subunit, mitochondrial region 4
namespace: region
def: "." [DPO:curators, PMID:11902841]
comment: This region is disordered in monomer B, but monomer A contains the additional  disordered lysine residue at position 648 in addition to those in monomer B.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000021 ! autoregulatory
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001012
name: inosine-5'-monophosphate dehydrogenase region 1
namespace: region
def: "." [DPO:curators, PMID:9271497]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001013
name: inosine-5'-monophosphate dehydrogenase region 2
namespace: region
def: "." [DPO:curators, PMID:9271497]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001014
name: inosine-5'-monophosphate dehydrogenase region 3
namespace: region
def: "." [DPO:curators, PMID:9271497]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001015
name: inosine-5'-monophosphate dehydrogenase region 4
namespace: region
def: "." [DPO:curators, PMID:9271497]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001016
name: lipid A export ATP-binding/permease protein msbA region 1
namespace: region
def: "." [DPO:curators, PMID:11546864]
comment: The electron densities are "diffuse" for amino acids 58 through 63. 
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023294 ! lipid A export ATP-binding/permease protein msbA
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001017
name: lipid A export ATP-binding/permease protein msbA region 2
namespace: region
def: "." [DPO:curators, PMID:11546864]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023294 ! lipid A export ATP-binding/permease protein msbA
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001018
name: lipid A export ATP-binding/permease protein msbA region 3
namespace: region
def: "." [DPO:curators, PMID:11546864]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023294 ! lipid A export ATP-binding/permease protein msbA

[Term]
id: DPO:001019
name: multidrug resistance protein mexA region 1
namespace: region
def: "." [DPO:curators, PMID:15226509]
comment: The mature protein, consisiting of resisdues 24-383, was used for structure determination.  It also had a C24S mutation to prevent fatty acid attachment at the N-terminal.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000042 ! protein-lipid interaction

[Term]
id: DPO:001020
name: multidrug resistance protein mexA region 2
namespace: region
def: "." [DPO:curators, PMID:15226509]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000042 ! protein-lipid interaction

[Term]
id: DPO:001021
name: sulfotransferase family cytosolic 2B member 1 [Isoform 2 (SULT2B1a)(A)] region 1
namespace: region
def: "." [DPO:curators, PMID:12923182, PMID:12923182]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001022
name: sulfotransferase family cytosolic 2B member 1 [Isoform 2 (SULT2B1a)(A)] region 2
namespace: region
def: "." [DPO:curators, PMID:12923182]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001023
name: chemotaxis protein cheA [Isoform cheA(L)(Long)(Large)] region 1
namespace: region
def: "." [DPO:curators, PMID:8639521]
comment: The experimental fragment consisted of residues 124-257 of the Swiss Prot sequence.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000025252 ! chemotaxis protein cheA isoform 2
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001024
name: chemotaxis protein cheA [Isoform cheA(L)(Long)(Large)] region 2
namespace: region
def: "." [DPO:curators, PMID:8639521]
comment: The experimental fragment consisted of residues 124-257 of the Swiss Prot sequence.
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000025252 ! chemotaxis protein cheA isoform 2
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001025
name: ras-related C3 botulinum toxin substrate 1 [Isoform A (Rac1A)] region 1
namespace: region
def: "." [DPO:curators, PMID:14625275]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001026
name: ras-related C3 botulinum toxin substrate 1 [Isoform A (Rac1A)] region 2
namespace: region
def: "." [DPO:curators, PMID:14625275]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001027
name: 10 kDa chaperonin region 1
namespace: region
def: "." [DPO:curators, PMID:8876186, PMID:16223749, PMID:15238634]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000011 ! chaperone
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001028
name: biotin carboxyl carrier protein of acetyl-CoA carboxylase region 1
namespace: region
def: "." [DPO:curators, PMID:11956202]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001029
name: protein jagged-1 region 1
namespace: region
def: "." [DPO:curators, PMID:16427310]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000001921 ! protein jagged-1
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001030
name: thymidine kinase region 1
namespace: region
def: "." [DPO:curators, PMID:7628623]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001031
name: thymidine kinase region 2
namespace: region
def: "." [DPO:curators, PMID:7628623]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001032
name: thymidine kinase region 3
namespace: region
def: "." [DPO:curators, PMID:7628623]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001033
name: thymidine kinase region 4
namespace: region
def: "." [DPO:curators, PMID:9336833]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001034
name: thymidine kinase region 5
namespace: region
def: "." [DPO:curators, PMID:9336833]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001035
name: thymidine kinase region 6
namespace: region
def: "." [DPO:curators, PMID:9336833]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001036
name: protein phosphatase 1 regulatory subunit 1B region 1
namespace: region
def: "." [DPO:curators, PMID:6319628]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:001037
name: DNA-binding protein fis region 1
namespace: region
def: "." [DPO:curators, PMID:1619650, PMID:1946369, PMID:11183780, PMID:9362499]
comment: A mutant Fis crystal structure reveals that the transactivation domain of Fis contains two beta-hairpin arms that protrude over 20 Å from the protein core (EMBO J. 1997, 16, 6860-6873). The most critical activating residues are located near the tips of the beta-arms.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000022626 ! DNA-binding protein fis
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state
relationship: has_structural_basis_for_function DPO:000059 ! order to disorder transition

[Term]
id: DPO:001038
name: histone H1 region 1
namespace: region
def: "." [DPO:curators, PMID:14654695, PMID:15050829, PMID:15878177]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001039
name: protein Rev region 1
namespace: region
def: "." [DPO:curators, PMID:7510518, PMID:2125482]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000036 ! nuclear localization
relationship: has_subfunction DPO:000038 ! polymerization
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001040
name: band 3 anion transport protein region 1
namespace: region
def: "." [DPO:curators, PMID:11049968, PMID:16285715]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000002033 ! band 3 anion transport protein
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:001041
name: band 3 anion transport protein region 2
namespace: region
def: "." [DPO:curators, PMID:11049968, PMID:16285715]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000002033 ! band 3 anion transport protein
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001042
name: serine/threonine-protein kinase PLK1 region 1
namespace: region
def: "." [DPO:curators, PMID:14592974]
comment: The fragment used to determine this structure consisted of residues 345-603.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012870 ! serine/threonine-protein kinase PLK1
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001043
name: serine/threonine-protein kinase PLK1 region 2
namespace: region
def: "." [DPO:curators, PMID:14592974]
comment: The fragment used to determine this structure consisted of residues 345-603.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012870 ! serine/threonine-protein kinase PLK1

[Term]
id: DPO:001044
name: serine/threonine-protein kinase PLK1 region 3
namespace: region
def: "." [DPO:curators, PMID:14592974]
comment: The fragment used to determine this structure consisted of residues 345-603.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012870 ! serine/threonine-protein kinase PLK1

[Term]
id: DPO:001045
name: L-rhamnose isomerase region 1
namespace: region
def: "." [DPO:curators, PMID:10891278]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023733 ! L-rhamnose isomerase
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001046
name: non-histone chromosomal protein 6A region 1
namespace: region
def: "." [DPO:curators, PMID:10228169]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001047
name: non-histone chromosomal protein 6A region 2
namespace: region
def: "." [DPO:curators, PMID:10228169]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001048
name: lactose operon repressor region 1
namespace: region
def: "." [DPO:curators, PMID:8683581]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023070 ! lactose operon repressor

[Term]
id: DPO:001049
name: lactose operon repressor region 2
namespace: region
def: "." [DPO:curators, PMID:8683581]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023070 ! lactose operon repressor
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001050
name: lactose operon repressor region 3
namespace: region
def: "." [DPO:curators, PMID:8683581]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023070 ! lactose operon repressor

[Term]
id: DPO:001051
name: lactose operon repressor region 4
namespace: region
def: "." [DPO:curators, PMID:9032054]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023070 ! lactose operon repressor
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001052
name: lactose operon repressor region 5
namespace: region
def: "." [DPO:curators, PMID:9032054]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023070 ! lactose operon repressor
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001053
name: lactose operon repressor region 6
namespace: region
def: "." [DPO:curators, PMID:8638105]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023070 ! lactose operon repressor
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001054
name: UPF0424 protein At3g04780 region 1
namespace: region
def: "." [DPO:curators, PMID:15741346]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001055
name: transitional endoplasmic reticulum ATPase region 1
namespace: region
def: "." [DPO:curators, PMID:15740751]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000017273 ! transitional endoplasmic reticulum ATPase
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000059 ! order to disorder transition

[Term]
id: DPO:001056
name: transitional endoplasmic reticulum ATPase region 2
namespace: region
def: "." [DPO:curators, PMID:15740751]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000017273 ! transitional endoplasmic reticulum ATPase

[Term]
id: DPO:001057
name: canavalin region 1
namespace: region
def: "." [DPO:curators, PMID:8310056]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001058
name: canavalin region 2
namespace: region
def: "." [DPO:curators, PMID:8310056]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001059
name: canavalin region 3
namespace: region
def: "." [DPO:curators, PMID:8310056]
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:001060
name: canavalin region 4
namespace: region
def: "." [DPO:curators, PMID:8310056]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001061
name: DNA repair protein RAD52 homolog region 1
namespace: region
def: "." [DPO:curators, PMID:12370410]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000013678 ! DNA repair protein RAD52
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001062
name: cysteine and glycine-rich protein 2 region 1
namespace: region
def: "." [DPO:curators, PMID:9722554]
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001063
name: cyclic nucleotide-gated cation channel beta-1 [Isoform GARP1] region 1
namespace: region
def: "." [DPO:curators, PMID:16280326]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000012 ! entropic chain
relationship: has_function DPO:000017 ! molecular recognition scavenger
relationship: has_subfunction DPO:000027 ! entropic bristle
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001064
name: werner syndrome ATP-dependent helicase region 1
namespace: region
def: "." [DPO:curators, PMID:16339893]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000017455 ! werner syndrome ATP-dependent helicase

[Term]
id: DPO:001065
name: alpha-crystallin A chain region 1
namespace: region
def: "." [DPO:curators, PMID:12235146, PMID:9650074]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000005907 ! alpha-crystallin A chain
relationship: has_function DPO:000011 ! chaperone
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001066
name: alpha-crystallin B chain region 1
namespace: region
def: "." [DPO:curators, PMID:12235146, PMID:9650074]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000005908 ! alpha-crystallin B chain
relationship: has_function DPO:000011 ! chaperone
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001067
name: suppressor of cytokine signaling 3 region 1
namespace: region
def: "." [DPO:curators, PMID:16302975]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000015394 ! suppressor of cytokine signaling 3
relationship: has_subfunction DPO:000023 ! disordered region is not essential for protein function

[Term]
id: DPO:001068
name: phosphoprotein region 1
namespace: region
def: "." [DPO:curators, PMID:16361428]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001069
name: phosphoprotein region 2
namespace: region
def: "." [DPO:curators, PMID:16361428]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001070
name: FH1/FH2 domain-containing protein 1 region 1
namespace: region
def: "." [DPO:curators, PMID:16361249]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000007516 ! FH1/FH2 domain-containing protein 1
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000021 ! autoregulatory
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001071
name: bcl-2-like protein 1 [Isoform Bcl-X(L)] region 1
namespace: region
def: "." [DPO:curators, PMID:9346936]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000021 ! autoregulatory

[Term]
id: DPO:001072
name: bcl-2-like protein 1 [Isoform Bcl-X(L)] region 2
namespace: region
def: "." [DPO:curators, PMID:9346936]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001073
name: xanthine dehydrogenase/oxidase region 1
namespace: region
def: "." [DPO:curators, PMID:11005854]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000026 ! electron transfer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001074
name: xanthine dehydrogenase/oxidase region 2
namespace: region
def: "." [DPO:curators, PMID:11005854]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000026 ! electron transfer
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001075
name: xanthine dehydrogenase/oxidase region 3
namespace: region
def: "." [DPO:curators, PMID:11005854]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000026 ! electron transfer
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001076
name: AP-2 complex subunit mu-1 region 1
namespace: region
def: "." [DPO:curators, PMID:12086608]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001077
name: AP-2 complex subunit mu-1 region 2
namespace: region
def: "." [DPO:curators, PMID:12086608]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001078
name: AP-2 complex subunit mu-1 region 3
namespace: region
def: "." [DPO:curators, PMID:12086608]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001079
name: AP-2 complex subunit mu-1 region 4
namespace: region
def: "." [DPO:curators, PMID:12086608]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001080
name: tetratricopeptide repeat protein 11 region 1
namespace: region
def: "." [DPO:curators, PMID:14623186]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001081
name: tetratricopeptide repeat protein 11 region 2
namespace: region
def: "." [DPO:curators, PMID:14623186]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001082
name: tetratricopeptide repeat protein 11 region 3
namespace: region
def: "." [DPO:curators, PMID:14623186]
comment: The length of the recombinant protein is the same as that of the wild-type protein but the last seven amino acids are EHHHHHH instead of AVSKSKS.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001083
name: rab proteins geranylgeranyltransferase component A 1 region 1
namespace: region
def: "." [DPO:curators, PMID:12620235, PMID:11886217]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001084
name: rab proteins geranylgeranyltransferase component A 1 region 2
namespace: region
def: "." [DPO:curators, PMID:12620235, PMID:11886217]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001085
name: rab proteins geranylgeranyltransferase component A 1 region 3
namespace: region
def: "." [DPO:curators, PMID:12620235, PMID:11886217]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001086
name: rab proteins geranylgeranyltransferase component A 1 region 4
namespace: region
def: "." [DPO:curators, PMID:12620235, PMID:11886217]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001087
name: rab proteins geranylgeranyltransferase component A 1 region 5
namespace: region
def: "." [DPO:curators, PMID:12620235, PMID:11886217]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001088
name: rab proteins geranylgeranyltransferase component A 1 region 6
namespace: region
def: "." [DPO:curators, PMID:12620235, PMID:11886217]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001089
name: rho-GTPase-activating protein 1 region 1
namespace: region
def: "." [DPO:curators, PMID:9009196]
comment: Residues 1-34 of the fragment correspond to residues 198-231 of the full-length protein.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001090
name: ectodysplasin A region 2
namespace: region
def: "." [DPO:curators, PMID:14656435]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001091
name: ectodysplasin A region 3
namespace: region
def: "." [DPO:curators, PMID:14656435]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001092
name: colicin-N region 1
namespace: region
def: "." [DPO:curators, PMID:15004032, PMID:12679333, PMID:11099384, PMID:9680221, PMID:9687368, PMID:15465872, PMID:18573254]
comment: The translocation domain of this protein is needed for the importing of the protein across the outer membrane.  It binds to the third domain of TolA protein, and probably also binds to the OmpF protein.  Residues 1-40 may be removed without abolishing toxicity.  Residues 40-67 are essential for TolA binding.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001093
name: ribonucleoside-diphosphate reductase M2 subunit region 1
namespace: region
def: "." [DPO:curators, PMID:8876648, PMID:7589490]
comment: The N-terminal residues are not essential for enzymatic activity but the N-terminal tail may function in cell-cycle regulation of the enzyme and protein degradation.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001094
name: ribonucleoside-diphosphate reductase M2 subunit region 2
namespace: region
def: "." [DPO:curators, PMID:8876648, PMID:8130196, PMID:7589490]
comment: The C-terminus of R2 is involved in the interaction between R1 and R2.  The C-terminal seven residues go from disorder to order upon binding to R1.  
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001095
name: gamma-aminobutyric acid type B receptor, subunit 1 [Precursor] region 1
namespace: region
def: "." [DPO:curators, PMID:15304491]
comment: This region corresponds to the N-terminal CCP-module like sequence.
is_a: DPO:000010 ! disordered - molten globule region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001096
name: mothers against decapentaplegic homolog 4 region 1
namespace: region
def: "." [DPO:curators, PMID:10647180]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000033 ! intraprotein interaction
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001097
name: mothers against decapentaplegic homolog 4 region 2
namespace: region
def: "." [DPO:curators, PMID:10647180]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000033 ! intraprotein interaction
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001098
name: mothers against decapentaplegic homolog 4 region 3
namespace: region
def: "." [DPO:curators, PMID:10647180]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000033 ! intraprotein interaction
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001099
name: mothers against decapentaplegic homolog 4 region 4
namespace: region
def: "." [DPO:curators, PMID:10647180]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000033 ! intraprotein interaction
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001100
name: mothers against decapentaplegic homolog 4 region 5
namespace: region
def: "." [DPO:curators, PMID:10647180]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000033 ! intraprotein interaction
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001101
name: mothers against decapentaplegic homolog 4 region 6
namespace: region
def: "." [DPO:curators, PMID:10647180]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000033 ! intraprotein interaction
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001102
name: mothers against decapentaplegic homolog 4 region 7
namespace: region
def: "." [DPO:curators, PMID:10647180]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000033 ! intraprotein interaction
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001103
name: mothers against decapentaplegic homolog 4 region 8
namespace: region
def: "." [DPO:curators, PMID:10647180]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000033 ! intraprotein interaction
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000059 ! order to disorder transition

[Term]
id: DPO:001104
name: mothers against decapentaplegic homolog 4 region 9
namespace: region
def: "." [DPO:curators, PMID:10647180]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000033 ! intraprotein interaction
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001105
name: mothers against decapentaplegic homolog 4 region 10
namespace: region
def: "." [DPO:curators, PMID:10647180]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000033 ! intraprotein interaction
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001106
name: hypothetical protein MJ0246 region 1
namespace: region
def: "." [DPO:curators, PMID:15322276, PMID:9506949]
comment: In the Vamvaca et al. paper, the six terminal amino acid residues of the protein were replaced by the following sequence: LEHHHHHH.
is_a: DPO:000010 ! disordered - molten globule region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001107
name: major prion protein region 1
namespace: region
def: "." [DPO:curators, PMID:10618385]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001108
name: major prion protein region 2
namespace: region
def: "." [DPO:curators, PMID:10618385]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001109
name: ankyrin-2 (202 KDa splice form) region 1
namespace: region
def: "." [DPO:curators, PMID:16368689]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000004034 ! ankyrin-2
relationship: has_subfunction DPO:000021 ! autoregulatory
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001110
name: NF-kappaB inhibitor alpha region 1
namespace: region
def: "." [DPO:curators, PMID:9872404, PMID:7891711]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003293 ! NF-kappa-B inhibitor alpha

[Term]
id: DPO:001111
name: NF-kappaB inhibitor alpha region 2
namespace: region
def: "." [DPO:curators, PMID:9872404, PMID:7891711]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003293 ! NF-kappa-B inhibitor alpha
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001112
name: transcription factor HY5 region 1
namespace: region
def: "." [DPO:curators, PMID:17001643]
is_a: DPO:000009 ! disordered - pre-molten globule region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000057 ! pre-molten globule to order transition

[Term]
id: DPO:001113
name: opaque 2 region 1
namespace: region
def: "." [DPO:curators, PMID:15096055]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001114
name: lipoprotein GNA1870 (type 1) region 1
namespace: region
def: "." [DPO:curators, PMID:16407174]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001115
name: peroxisomal biogenesis factor 5 region 1
namespace: region
def: "." [DPO:curators, PMID:16403517, PMID:8991089, PMID:11865044]
is_a: DPO:000009 ! disordered - pre-molten globule region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000011 ! chaperone
relationship: has_subfunction DPO:000048 ! self-transport through channel
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000054 ! pre-molten globule state

[Term]
id: DPO:001116
name: cryptochrome 2 region 1
namespace: region
def: "." [DPO:curators, PMID:15751956]
comment: The C-terminal domain of human CRY2 (hCRY2-CT, residues 490-593) was studied.
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000033 ! intraprotein interaction
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001117
name: cryptochrome 1 apoprotein region 1
namespace: region
def: "." [DPO:curators, PMID:15751956]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000033 ! intraprotein interaction
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001118
name: H/ACA ribonucleoprotein complex subunit 3 region 1
namespace: region
def: "." [DPO:curators, PMID:16373493]
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001119
name: H/ACA ribonucleoprotein complex subunit 3 region 2
namespace: region
def: "." [DPO:curators, PMID:16373493]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001120
name: H/ACA ribonucleoprotein complex subunit 3 region 3
namespace: region
def: "." [DPO:curators, PMID:16373493]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001121
name: sorting nexin GRD19 region 1
namespace: region
def: "." [DPO:curators, PMID:14514667]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001122
name: sorting nexin GRD19 region 2
namespace: region
def: "." [DPO:curators, PMID:14514667]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000059 ! order to disorder transition

[Term]
id: DPO:001123
name: prion protein region 1
namespace: region
def: "." [DPO:curators, PMID:12890024, PMID:11685242]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001124
name: tricorn protease region 1
namespace: region
def: "." [DPO:curators, PMID:11719810]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001125
name: tricorn protease region 2
namespace: region
def: "." [DPO:curators, PMID:11719810]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001126
name: ubiquitin-like 1-activating enzyme E1A region 1
namespace: region
def: "." [DPO:curators, PMID:15660128]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001127
name: ubiquitin-like 1-activating enzyme E1A region 2
namespace: region
def: "." [DPO:curators, PMID:15660128]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001128
name: ubiquitin-like 1-activating enzyme E1B region 1
namespace: region
def: "." [DPO:curators, PMID:15660128]
comment: Residues 1-158 are part of the protein's adenylation domain.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001129
name: ubiquitin-like 1-activating enzyme E1B region 2
namespace: region
def: "." [DPO:curators, PMID:15660128]
comment: Residues 159-386 make up the catalytic cys domain of the protein.  It contains Cys173 which is the catalytic cysteine responsible for E1-SUMO-thioester bond formation.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001130
name: ubiquitin-like 1-activating enzyme E1B region 3
namespace: region
def: "." [DPO:curators, PMID:15660128]
comment: Residues 159-386 make up the catalytic cys domain of the protein.  It contains Cys173 which is the catalytic cysteine responsible for E1-SUMO-thioester bond formation.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001131
name: ubiquitin-like 1-activating enzyme E1B region 4
namespace: region
def: "." [DPO:curators, PMID:15660128]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000036 ! nuclear localization

[Term]
id: DPO:001132
name: ribonucleoside-diphosphate reductase small chain 1 region 1
namespace: region
def: "." [DPO:curators, PMID:11526233]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001133
name: ribonucleoside-diphosphate reductase small chain 1 region 2
namespace: region
def: "." [DPO:curators, PMID:11526233]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001134
name: ribonucleoside-diphosphate reductase small chain 1 region 3
namespace: region
def: "." [DPO:curators, PMID:11526233]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:001135
name: ribonucleoside-diphosphate reductase small chain 2 region 1
namespace: region
def: "." [DPO:curators, PMID:11526233]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001136
name: ribonucleoside-diphosphate reductase small chain 2 region 2
namespace: region
def: "." [DPO:curators, PMID:11526233]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001137
name: ribonucleoside-diphosphate reductase small chain 2 region 3
namespace: region
def: "." [DPO:curators, PMID:11526233]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001138
name: ribonucleoside-diphosphate reductase small chain 2 region 4
namespace: region
def: "." [DPO:curators, PMID:11526233]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:001139
name: decorin [Precursor] region 1
namespace: region
def: "." [DPO:curators, PMID:15501918]
comment: This region corresponds to residues 1-21 of the mature protein.
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000032 ! glycosylation

[Term]
id: DPO:001140
name: growth factor receptor-bound protein 14 region 1
namespace: region
def: "." [DPO:curators, PMID:14623073, PMID:15465854]
comment: Residues 399-407 may be transiently structured, and may be important in the binding of Grb14 binding to its partner via a structural transition.
is_a: DPO:000008 ! disordered - extended region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001141
name: dystroglycan [Precursor] region 1
namespace: region
def: "." [DPO:curators, PMID:11257514, PMID:14622018]
comment: This protein is highly disordered, but steady-state NOE experiments indicate that the protein presents two regions of different mobility. The first one, between residues 659-722, is characterized by a limited degree of mobility, whereas the C-terminal portion, containing about 30 amino acids, is highly flexible.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001142
name: androgen receptor region 1
namespace: region
def: "." [DPO:curators, PMID:11896058, PMID:15023052]
comment: Binding of NTD to target protein TFIIF transcription factor induces folding into a more stable conformation.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000004191 ! androgen receptor
relationship: has_function DPO:000014 ! modification site
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001143
name: androgen receptor region 2
namespace: region
def: "." [DPO:curators, PMID:11896058]
is_a: DPO:000006 ! ordered region
relationship: part_of PRO:000004191 ! androgen receptor
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000052 ! ordered state

[Term]
id: DPO:001144
name: androgen receptor region 3
namespace: region
def: "." [DPO:curators, PMID:11896058]
is_a: DPO:000006 ! ordered region
relationship: part_of PRO:000004191 ! androgen receptor
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000052 ! ordered state

[Term]
id: DPO:001145
name: C-terminal-binding protein 1 region 1
namespace: region
def: "." [DPO:curators, PMID:16597837]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000036 ! nuclear localization
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001146
name: DNA repair enzyme region 1
namespace: region
def: "." [DPO:curators, PMID:16605254]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000043 ! protein-mRNA binding
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001147
name: positive cofactor 4 region 1
namespace: region
def: "." [DPO:curators, PMID:16605275]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000018 ! acetylation
relationship: has_subfunction DPO:000021 ! autoregulatory
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001148
name: B-cell antigen receptor complex-associated protein alpha-chain [Precursor] region 1
namespace: region
def: "." [DPO:curators, PMID:14967045]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000001285 ! B-cell antigen receptor complex-associated protein alpha-chain
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000038 ! polymerization
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001149
name: B-cell antigen receptor complex-associated protein beta-chain [Precursor] region 1
namespace: region
def: "." [DPO:curators, PMID:14967045]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000001286 ! B-cell antigen receptor complex-associated protein beta-chain
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_function DPO:000017 ! molecular recognition scavenger
relationship: has_subfunction DPO:000038 ! polymerization
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001150
name: DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide region 1
namespace: region
def: "." [DPO:curators, PMID:16632472]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012994 ! DNA-directed RNA polymerases I, II, and III subunit RPABC3

[Term]
id: DPO:001151
name: T-cell surface glycoprotein CD3 delta chain [Precursor] region 1
namespace: region
def: "." [DPO:curators, PMID:14967045]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000001019 ! CD3 delta
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000038 ! polymerization
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001152
name: T-cell surface glycoprotein CD3 epsilon chain [Precursor] region 1
namespace: region
def: "." [DPO:curators, PMID:14967045]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000001020 ! CD3 epsilon
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000038 ! polymerization
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001153
name: T-cell surface glycoprotein CD3 gamma chain [Precursor] region 1
namespace: region
def: "." [DPO:curators, PMID:14967045]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000001021 ! CD3 gamma
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000038 ! polymerization
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001154
name: high affinity immunoglobulin epsilon receptor gamma-subunit [Precursor] region 1
namespace: region
def: "." [DPO:curators, PMID:14967045]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000007432 ! high affinity immunoglobulin epsilon receptor subunit gamma
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000038 ! polymerization
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001155
name: nuclear protein 1 region 1
namespace: region
def: "." [DPO:curators, PMID:11056169]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000036 ! nuclear localization
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001156
name: cystatin B region 1
namespace: region
def: "." [DPO:curators, PMID:16155205]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001157
name: 50S ribosomal protein L11 region 1
namespace: region
def: "." [DPO:curators, PMID:8989327, PMID:9398519]
comment: Experimentally characterized region 1 was studied in the context of the C-terminal domain of the protein, 76 amino acids total length.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000041 ! protein-genomic RNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001158
name: acylphosphatase region 1
namespace: region
def: "." [DPO:curators, PMID:16287076, PMID:14724277]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001159
name: seryl-tRNA synthetase region 1
namespace: region
def: "." [DPO:curators, PMID:8128220, PMID:8230201]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000046 ! protein-tRNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001160
name: seryl-tRNA synthetase region 2
namespace: region
def: "." [DPO:curators, PMID:8128220, PMID:8654381]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000046 ! protein-tRNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001161
name: seryl-tRNA synthetase region 3
namespace: region
def: "." [DPO:curators, PMID:8128220, PMID:8654381, PMID:8230201]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000046 ! protein-tRNA binding
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001162
name: seryl-tRNA synthetase region 4
namespace: region
def: "." [DPO:curators, PMID:8128220]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000046 ! protein-tRNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001163
name: seryl-tRNA synthetase region 5
namespace: region
def: "." [DPO:curators, PMID:8230201]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001164
name: human serum albumin [Precursor] region 1
namespace: region
def: "." [DPO:curators, PMID:10388840]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003918 ! serum albumin

[Term]
id: DPO:001165
name: human serum albumin [Precursor] region 2
namespace: region
def: "." [DPO:curators, PMID:10388840]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000003918 ! serum albumin
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001166
name: undecaprenyl Pyrophosphatase synthase from E. Coli region 1
namespace: region
def: "." [DPO:curators, PMID:11581264]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000031 ! flexible linker/spacer

[Term]
id: DPO:001167
name: myomesin region 1
namespace: region
def: "." [DPO:curators, PMID:15890201]
comment: The elastic properties of Myomesin are modified by the alternative splicing that creates the EH-segment. The EH-isoform is the main myomesin species in the embryonic heart of all higher vertebrates.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000012 ! entropic chain
relationship: has_subfunction DPO:000029 ! entropic spring
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001168
name: bcl-2-like protein 11 region 1
namespace: region
def: "." [DPO:curators, PMID:16645638]
comment: To obtain soluble protein, it was necessary to delete the 27 C-terminal hydrophobic residues, creating the deltaC27 isoform. The deleted C-terminal residues are predicted to form a TM helix.
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000002187 ! Bcl2-like protein 11
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000020 ! apoptosis
relationship: has_structural_basis_for_function DPO:000053 ! disordered state
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001169
name: adenomatous polyposis coli region 1
namespace: region
def: "." [DPO:curators, PMID:16753179]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000004122 ! adenomatous polyposis coli protein
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001170
name: **Naked2** region 1
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000011233 ! protein naked cuticle 2
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000030 ! fatty acylation (myristolation and palmitoylation)
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001171
name: securin region 1
namespace: region
def: "." [DPO:curators, PMID:15929994]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000013486 ! securin
relationship: has_function DPO:000014 ! modification site
relationship: has_function DPO:000016 ! molecular recognition effector
relationship: has_subfunction DPO:000020 ! apoptosis
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001172
name: Nogo-B region 1
namespace: region
def: "." [DPO:curators, PMID:17397058]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001173
name: Nogo-B region 2
namespace: region
def: "." [DPO:curators, PMID:17397058]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001174
name: Nogo-A region 1
namespace: region
def: "." [DPO:curators, PMID:17397058]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001175
name: seminal vesicle secretory protein 4 [Precursor] region 1
namespace: region
def: "." [DPO:curators, PMID:18215165, PMID:17253790, PMID:14717694, PMID:10583398]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000018 ! acetylation
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:001176
name: plasmid partition protein ParG region 1
namespace: region
def: "." [DPO:curators, PMID:15951570]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001177
name: dehydrin DHN1 region 1
namespace: region
def: "." [DPO:curators, PMID:12529538]
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001178
name: abscisic acid stress ripening 1 region 1
namespace: region
def: "." [DPO:curators, PMID:17189335]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000034 ! metal binding
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001179
name: thylakoid soluble phosphoprotein region 1
namespace: region
def: "." [DPO:curators, PMID:17176085]
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001180
name: CP12 [A. thaliana] region 1
namespace: region
def: "." [DPO:curators, PMID:17947231]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:001181
name: fesselin region 1
namespace: region
def: "." [DPO:curators, PMID:17676886]
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001182
name: septin-4 region 1
namespace: region
def: "." [DPO:curators, PMID:17105210]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000014656 ! septin-4

[Term]
id: DPO:001183
name: latent membrane protein 2A N-terminal domain region 1
namespace: region
def: "." [DPO:curators, PMID:17174309]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001184
name: methyl-CpG-binding protein 2 region 2
namespace: region
def: "." [DPO:curators, PMID:17371874]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000010277 ! methyl-CpG-binding protein 2
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001185
name: methyl-CpG-binding protein 2 region 3
namespace: region
def: "." [DPO:curators, PMID:17371874]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000010277 ! methyl-CpG-binding protein 2

[Term]
id: DPO:001186
name: methyl-CpG-binding protein 2 region 4
namespace: region
def: "." [DPO:curators, PMID:17371874]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000010277 ! methyl-CpG-binding protein 2
relationship: has_subfunction DPO:000036 ! nuclear localization
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001187
name: methyl-CpG-binding protein 2 region 5
namespace: region
def: "." [DPO:curators, PMID:17371874]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000010277 ! methyl-CpG-binding protein 2
relationship: has_subfunction DPO:000040 ! protein-DNA binding

[Term]
id: DPO:001188
name: dribble region 1
namespace: region
def: "." [DPO:curators, PMID:16542639]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000045 ! protein-rRNA binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001189
name: melanophilin region 1
namespace: region
def: "." [DPO:curators, PMID:17513864]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000010456 ! melanophilin
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001190
name: VPg region 1
namespace: region
def: "." [DPO:curators, PMID:17971447]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000036 ! nuclear localization
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001191
name: cytochrome c oxidase copper chaperone [H. sapiens] region 1
namespace: region
def: "." [DPO:curators, PMID:18093982]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000005773 ! cytochrome c oxidase copper chaperone
relationship: has_function DPO:000011 ! chaperone
relationship: has_subfunction DPO:000034 ! metal binding

[Term]
id: DPO:001192
name: aplysia LAPS18-like protein region 1
namespace: region
def: "." [DPO:curators, PMID:18078811]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000051 ! transactivation (transcriptional activation)
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001193
name: huntingtin-interacting protein K region 1
namespace: region
def: "." [DPO:curators, PMID:18076027]
is_a: DPO:000009 ! disordered - pre-molten globule region
relationship: part_of PRO:000008854 ! huntingtin-interacting protein K
relationship: has_structural_basis_for_function DPO:000054 ! pre-molten globule state

[Term]
id: DPO:001194
name: parvalbumin alpha region 1
namespace: region
def: "." [DPO:curators, PMID:18260106]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001195
name: B-type natriuretic peptide region 1
namespace: region
def: "." [DPO:curators, PMID:17399679]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000011375 ! natriuretic peptides B

[Term]
id: DPO:001196
name: sigma-E factor negative regulatory protein region 1
namespace: region
def: "." [DPO:curators, PMID:18421143]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000023877 ! sigma-E factor negative regulatory protein
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000047 ! regulation of proteolysis in vivo
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Term]
id: DPO:001197
name: neuroligin 3 region 1
namespace: region
def: "." [DPO:curators, PMID:18456828]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000011256 ! neuroligin-3
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001198
name: NACHT, LRR and PYD domains-containing protein 1 region 1
namespace: region
def: "." [DPO:curators, PMID:14527388]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000020 ! apoptosis
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001199
name: beta-synuclein region 1
namespace: region
def: "." [DPO:curators, PMID:17681539]
is_a: DPO:000008 ! disordered - extended region
relationship: part_of PRO:000015324 ! beta-synuclein

[Term]
id: DPO:001200
name: vinculin region 1
namespace: region
def: "." [DPO:curators, PMID:15642262]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_subfunction DPO:000020 ! apoptosis
relationship: has_structural_basis_for_function DPO:000059 ! order to disorder transition

[Term]
id: DPO:001201
name: acetyl-CoA carboxylase region 1
namespace: region
def: "." [DPO:curators, PMID:15341732]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000030 ! fatty acylation (myristolation and palmitoylation)
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001202
name: acetyl-CoA carboxylase region 2
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_subfunction DPO:000030 ! fatty acylation (myristolation and palmitoylation)
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001203
name: farnesyltransferase, CAAX box, alpha region 1
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000059 ! order to disorder transition

[Term]
id: DPO:001204
name: chorismate Synthase region 1
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site

[Term]
id: DPO:001205
name: chorismate Synthase region 2
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001206
name: chorismate Synthase region 3
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001207
name: genome Polyprotein region 1
namespace: region
def: "." [DPO:curators, PMID:17971447, PMID:1431807]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001208
name: calcium-Dependent Protein Kinase-alpha region 1
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001209
name: calcium-Dependent Protein Kinase-alpha region 2
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001210
name: trafficking protein particle complex subunit 4 region 1
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001211
name: trafficking protein particle complex subunit 4 region 2
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001212
name: bcl2 antagonist of cell death region 1
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000002184 ! Bcl2 antagonist of cell death
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000020 ! apoptosis
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001213
name: B-Myc region 1
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000020 ! apoptosis
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001214
name: hemagglutinin [Precursor] region 1
namespace: region
def: "." [DPO:curators, PMID:8072525]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000023 ! disordered region is not essential for protein function
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001215
name: hemagglutinin [Precursor] region 2
namespace: region
def: "." [DPO:curators, PMID:8072525]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001216
name: pilosulin-1 [Precursor] region 1
namespace: region
def: "." [DPO:curators, PMID:15639237]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001217
name: paired box gene 6 isoform a region 1
namespace: region
def: "." [DPO:curators, PMID:10346815]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001218
name: EMILIN1 protein region 1
namespace: region
def: "." [DPO:curators, PMID:18463100]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001219
name: signal recognition particle 19 kDa protein region 1
namespace: region
def: "." [DPO:curators, PMID:17434535]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_subfunction DPO:000041 ! protein-genomic RNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001220
name: macrophage metalloelastase [Precursor] region 1
namespace: region
def: "." [DPO:curators, PMID:15809432]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001221
name: macrophage metalloelastase [Precursor] region 2
namespace: region
def: "." [DPO:curators, PMID:15809432]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001222
name: natriuretic peptides B [Precursor] region 1
namespace: region
def: "." [DPO:curators, PMID:17399679]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000021 ! autoregulatory
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001223
name: **Foot and Mouth Disease Virus** region 1
namespace: region
def: "." [DPO:curators, PMID:2537470]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_subfunction DPO:000049 ! structural mortar
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001224
name: **Foot and Mouth Disease Virus** region 2
namespace: region
def: "." [DPO:curators, PMID:2537470]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000049 ! structural mortar
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001225
name: serum response factor region 1
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000040 ! protein-DNA binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001226
name: alkylmercury Lyase region 1
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001227
name: alkylmercury Lyase region 2
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001228
name: alkylmercury Lyase region 3
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001229
name: alkylmercury Lyase region 4
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001230
name: ataxin-3 region 1
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000021 ! autoregulatory
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001231
name: ataxin-3 region 2
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000021 ! autoregulatory
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001232
name: amidophosphoribosyltransferase region 1
namespace: region
def: "." [DPO:curators, PMID:9914248]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001233
name: amidophosphoribosyltransferase region 2
namespace: region
def: "." [DPO:curators, PMID:9914248]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001234
name: amidophosphoribosyltransferase region 3
namespace: region
def: "." [DPO:curators, PMID:9914248]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001235
name: ribosomal protein L5 region 1
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_subfunction DPO:000021 ! autoregulatory
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001236
name: ribosomal protein L5 region 2
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001237
name: pollen allergen Ole e 6 region 1
namespace: region
def: "." [DPO:curators, PMID:15247256]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000049 ! structural mortar
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001238
name: ras-related protein Ral-A region 1
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001239
name: ras-related protein Ral-A region 2
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001240
name: ras-related protein Ral-A region 3
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001241
name: brazzein region 1
namespace: region
def: "." [DPO:curators]
comment: Contains sweet tasting receptors on protein.
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000014 ! modification site
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000053 ! disordered state

[Term]
id: DPO:001242
name: deoxycytidylate deaminase region 1
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000031 ! flexible linker/spacer
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001243
name: protein starmaker [Precursor] region 1
namespace: region
def: "." [DPO:curators]
is_a: DPO:000007 ! disordered region
relationship: has_function DPO:000015 ! molecular assembly
relationship: has_subfunction DPO:000037 ! phosphorylation
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_subfunction DPO:000044 ! protein-protein binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001244
name: flavivirus E Glycoprotein region 1
namespace: region
def: "." [DPO:curators, PMID:15341726]
comment: This region is part of a flexible loop spanning from residues 16-20.
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001245
name: flavivirus E Glycoprotein region 2
namespace: region
def: "." [DPO:curators, PMID:15341726]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001246
name: IA3 region 1
namespace: region
def: "." [DPO:curators, PMID:15065849]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000047 ! regulation of proteolysis in vivo
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001247
name: RWD domain-containing protein 1 region 1
namespace: region
def: "." [DPO:curators, PMID:18954556]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000014370 ! RWD domain-containing protein 1

[Term]
id: DPO:001248
name: core protein region 1
namespace: region
def: "." [DPO:curators, PMID:18992225]
is_a: DPO:000007 ! disordered region

[Term]
id: DPO:001249
name: adenylate cyclase region 1
namespace: region
def: "." [DPO:curators, PMID:19015266]
is_a: DPO:000007 ! disordered region
relationship: has_subfunction DPO:000050 ! substrate/ligand binding
relationship: has_structural_basis_for_function DPO:000056 ! disorder to order transition

[Term]
id: DPO:001250
name: PEP-19 region 1
namespace: region
def: "." [DPO:curators, PMID:19106096]
is_a: DPO:000007 ! disordered region
relationship: part_of PRO:000012431 ! purkinje cell protein 4
relationship: has_subfunction DPO:000044 ! protein-protein binding

[Typedef]
id: has_function
name: has_function

[Typedef]
id: has_subfunction
name: has_subfunction

[Typedef]
id: has_structural_basis_for_function
name: has_structural_basis_for_function
[Typedef]
id: has_function
name: has_function

[Typedef]
id: has_subfunction
name: has_subfunction

[Typedef]
id: has_structural_basis_for_function
name: has_structural_basis_for_function