| General information | | DisProt: | DP00027 | | Name: | Negative regulator of flagellin synthesis | | Synonym(s): | FLGM_SALTY
Anti-sigma-28 factor
FlgM
| | First appeared in release: | Release 1.0 (08/01/2003) | | UniProt: | P26477 | | UniGene: | | | SwissProt: | FLGM_SALTY | | TrEMBL: | | | NCBI (GI): | 120306 | | Source organism: | Salmonella typhimurium | | Sequence length: | 97 | | Percent disordered: | 100% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MSIDRTSPLK PVSTVQTRET SDTPVQKTRQ EKTSAATSAS VTLSDAQAKL MQPGVSDINM - 60
ERVEALKTAI RNGELKMDTG KIADSLIREA QSYLQSK
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| Functional narrative |
Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of fliA by directly binding to fliA.
The N-terminal domain is essential for export and the C-terminal domain possess the fliA binding site.
Belongs to the flgM family.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 1 - 97 | | Length: | 97 | | Region sequence: |
MSIDRTSPLKPVSTVQTRETSDTPVQKTRQEKTSAATSASVTLSDAQAKLMQPGVSDINM
ERVEALKTAIRNGELKMDTGKIADSLIREAQSYLQSK | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | | | Functional subclasses: | Protein inhibitor
Protein-protein binding
| Detection methods:
- Nuclear magnetic resonance (NMR) (298 K; pH: 6.2; protein (sample) 10 mM; sodium phosphate (buffer) 10 mM; NaCl 10 mM; D2O 5 %; NaN3 0.02 %; General Electric Omega 500 MHz (spectrometer))
| References:
- Daughdrill GW, Chadsey MS, Karlinsey JE, Hughes KT, Dahlquist FW. "The C-terminal half of the anti-sigma factor, FlgM, becomes structured when bound to its target, sigma 28." Nat Struct Biol. 1997; 4(4): 285-91. PubMed: 9095196
| Comments:
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| References |
- Daughdrill GW, Chadsey MS, Karlinsey JE, Hughes KT, Dahlquist FW. "The C-terminal half of the anti-sigma factor, FlgM, becomes structured when bound to its target, sigma 28." Nat Struct Biol. 1997; 4(4): 285-91. PubMed: 9095196
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| Comments |
AV 7-29-2010 PubMed: 9095196
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