Structure of pvu II DNA-(cytosine N4) methyltransferase, an example of domain permutation and protein fold assignment

Modification methylase PvuIIMTP2_PROVUM.PvuIIN-4 cytosine-specific methyltransferase PvuIIN(4)-cytosine-specific DNA methylaseEC 2.1.1.113P11409MTP2_PROVU1709165Proteus vulgarisMLNFGKKPAYTTSNGSMYIGDSLELLESFPEESISLVMTSPPFALQRKKEYGNLEQHEYVDWFLSFAKVVNKKLKPDGSFVVDFGGAYMKGVPARSIYNFRVLIRMIDEVGFFLAEDFYWFNPSKLPSPIEWVNKRKIRVKDAVNTVWWFSKTEWPKSDITKVLAPYSDRMKKLIEDPDKFYTPKTRPSGHDIGKSFSKDNGGSIPPNLLQISNSESNGQYLANCKLMGIKAHPARFPAKLPEFFIRMLTEPDDLVVDIFGGSNTTGLVAERESRKWISFEMKPEYVAASAFRFLDNNISEEKITDIYNRILNGESLDLNSIIDisordered166203PYSDRMKKLIEDPDKFYTPKTRPSGHDIGKSFSKDNGGComplexNativeMethylationX-ray crystallographyMarResearch imaging plate detectorbeamline X12-C Paper9207015Gong W, O'Gara M, Blumenthal RM, Cheng XStructure of pvu II DNA-(cytosine N4) methyltransferase, an example of domain permutation and protein fold assignment1997Nucleic Acids Res25142702-15DisorderedP loop7081VNKKLKPDGSFVComplexNativeFunction arises via a disorder to order transitionProtein-DNA bindingMethylationX-ray crystallographybeamline X12-C MarResearch imaging plate detectorPaper9207015Gong W, O'Gara M, Blumenthal RM, Cheng XStructure of pvu II DNA-(cytosine N4) methyltransferase, an example of domain permutation and protein fold assignment1997Nucleic Acids Res25142702-15The SwissProt sequence is the long form of the protein(aa1-aa336). The disordered regions were found using the short form of the protein. (aa14-aa336)The referenced paper has disordered region 1 as residues 179-216 and region 2 as residues 57-68. They used the short form of Modification methylase PvuII which has 13 less N-terminal residues and is numbered 14-336.AV 6-28-2010 PubMed: 9207015