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DP00489: Decorin [Precursor]FASTA viewXML view

General information
DisProt:DP00489
Name:Decorin [Precursor]
Synonym(s):Bone proteoglycan II
PG-S2
First appeared in release:Release 3.2 (05/26/2006)
UniProt: 
UniGene: 
SwissProt: P21793
TrEMBL:  
NCBI (GI):  
Source organism:Bos taurus (Bovine)
Sequence length:360
Percent disordered:7%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MKATIIFLLV AQVSWAGPFQ QKGLFDFMLE DEASGIGPEE HFPEVPEIEP MGPVCPFRCQ - 60
CHLRVVQCSD LGLEKVPKDL PPDTALLDLQ NNKITEIKDG DFKNLKNLHT LILINNKISK - 120
ISPGAFAPLV KLERLYLSKN QLKELPEKMP KTLQELRVHE NEITKVRKSV FNGLNQMIVV - 180
ELGTNPLKSS GIENGAFQGM KKLSYIRIAD TNITTIPQGL PPSLTELHLD GNKITKVDAA - 240
SLKGLNNLAK LGLSFNSISA VDNGSLANTP HLRELHLNNN KLVKVPGGLA DHKYIQVVYL - 300
HNNNISAIGS NDFCPPGYNT KKASYSGVSL FSNPVQYWEI QPSTFRCVYV RAAVQLGNYK - 360

Region 1: 31-51

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:31 - 51
Length:21
Region sequence:

DEASGIGPEEHFPEVPEIEPM

Modification type: Native
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Unknown
Functional subclasses: Glycosylation
Detection methods:
  1. X-ray crystallography (293 K; beta-octyl-D-glucoside (0.01%); polyethylene glycol 400 (25% vol/vol); sodium azide (0.02%); Tris (pH 7.75) 0.06 M)
References:
  1. Scott PG, McEwan PA, Dodd CM, Bergmann EM, Bishop PN, Bella J. "Crystal structure of the dimeric protein core of decorin, the archetypal small leucine-rich repeat proteoglycan." Proc Natl Acad Sci U S A. 2004; 101(44): 15633-8. PubMed: 15501918
Comments:
This region corresponds to residues 1-21 of the mature protein.


References

  1. Day AA, McQuillan CI, Termine JD, Young MR. "Molecular cloning and sequence analysis of the cDNA for small proteoglycan II of bovine bone." Biochem J. 1987; 248(3): 801-5. PubMed: 3435485



Comments


The decorin precursor has 360 amino acid residues which contains a 30-amino-acid residue propetide (residues 1-30). The mature protein is 330 amino acid residues long (residues 31-360).


The protein sequence in the paper matches 99% with the sequence in Swiss-Prot. In the paper, residues 283 and 289 are alanine and valine, instead of, valine and leucine.


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