| General information | | DisProt: | DP00489 | | Name: | Decorin | | Synonym(s): | PGS2_BOVIN
Bone proteoglycan II
PG-S2
| | First appeared in release: | Release 3.2 (05/26/2006) | | UniProt: | P21793 | | UniGene: | Bt.23178 | | SwissProt: | PGS2_BOVIN | | TrEMBL: | | | NCBI (GI): | 68845449 | | Source organism: | Bos taurus (Bovine) | | Sequence length: | 360 | | Percent disordered: | 7% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
| | | | | |
MKATIIFLLV AQVSWAGPFQ QKGLFDFMLE DEASGIGPEE HFPEVPEIEP MGPVCPFRCQ - 60
CHLRVVQCSD LGLEKVPKDL PPDTALLDLQ NNKITEIKDG DFKNLKNLHT LILINNKISK - 120
ISPGAFAPLV KLERLYLSKN QLKELPEKMP KTLQELRVHE NEITKVRKSV FNGLNQMIVV - 180
ELGTNPLKSS GIENGAFQGM KKLSYIRIAD TNITTIPQGL PPSLTELHLD GNKITKVDAA - 240
SLKGLNNLAK LGLSFNSISA VDNGSLANTP HLRELHLNNN KLVKVPGGLA DHKYIQVVYL - 300
HNNNISAIGS NDFCPPGYNT KKASYSGVSL FSNPVQYWEI QPSTFRCVYV RAAVQLGNYK - 360
|
| Functional narrative |
May affect the rate of fibrils formation.
|
| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
|
| Region 1 | | Type: | Disordered | | Name: | | | Location: | 31 - 51 | | Length: | 21 | | Region sequence: |
DEASGIGPEEHFPEVPEIEPM | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | Unknown
| | Functional subclasses: | Glycosylation
| Detection methods:
- X-ray crystallography (293 K; polyethylene glycol 400 (25% vol/vol); Tris (pH 7.75) 0.06 M; beta-octyl-D-glucoside (0.01%); sodium azide (0.02%))
| References:
- Scott PG, McEwan PA, Dodd CM, Bergmann EM, Bishop PN, Bella J. "Crystal structure of the dimeric protein core of decorin, the archetypal small leucine-rich repeat proteoglycan." Proc Natl Acad Sci U S A. 2004; 101(44): 15633-8. PubMed: 15501918
| Comments:This region corresponds to residues 1-21 of the mature protein.
|
| References |
- Day AA, McQuillan CI, Termine JD, Young MR. "Molecular cloning and sequence analysis of the cDNA for small proteoglycan II of bovine bone." Biochem J. 1987; 248(3): 801-5. PubMed: 3435485
|
| Comments |
The decorin precursor has 360 amino acid residues which contains a 30-amino-acid residue propetide (residues 1-30). The mature protein is 330 amino acid residues long (residues 31-360).
The protein sequence in the paper matches 99% with the sequence in Swiss-Prot. In the paper, residues 283 and 289 are alanine and valine, instead of, valine and leucine.
|
| If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
Disprot-footer
|
