Crystal structure of the dimeric protein core of decorin, the archetypal small leucine-rich repeat proteoglycan

DecorinPGS2_BOVINBone proteoglycan IIPG-S2P21793Bt.23178PGS2_BOVIN68845449Bos taurus (Bovine)MKATIIFLLVAQVSWAGPFQQKGLFDFMLEDEASGIGPEEHFPEVPEIEPMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRAAVQLGNYKMay affect the rate of fibrils formation.Disordered3151DEASGIGPEEHFPEVPEIEPMNativeRelationship to function unknownUnknownGlycosylationX-ray crystallography293polyethylene glycol 40025% vol/volTrispH 7.750.06beta-octyl-D-glucoside0.01%sodium azide0.02%Paper15501918Scott PG, McEwan PA, Dodd CM, Bergmann EM, Bishop PN, Bella JCrystal structure of the dimeric protein core of decorin, the archetypal small leucine-rich repeat proteoglycan2004Proc Natl Acad Sci U S A1014415633-8This region corresponds to residues 1-21 of the mature protein.The decorin precursor has 360 amino acid residues which contains a 30-amino-acid residue propetide (residues 1-30). The mature protein is 330 amino acid residues long (residues 31-360).The protein sequence in the paper matches 99% with the sequence in Swiss-Prot. In the paper, residues 283 and 289 are alanine and valine, instead of, valine and leucine.