| General information | | DisProt: | DP00655 | | Name: | Fermitin family homolog 1 | | Synonym(s): | FERM1_MOUSE
Unc-112-related protein 1
Kindlin-1
| | First appeared in release: | Release 5.1 (05/28/2010) | | UniProt: | P59113 | | UniGene: | Mm.209784 | | SwissProt: | FERM1_MOUSE | | TrEMBL: | | | NCBI (GI): | 122066624 | | Source organism: | Mus musculus (Mouse) | | Sequence length: | 677 | | Percent disordered: | 16% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MLSSGDLTSA SWELVVRVDH ANGEQQTEIT LRVSGDLHIG GVMLKLVEQM NIAQDWSDYA - 60
LWWEQKRCWL LKTHWTLDKC GVQADANLLF TPQHKMLRLR LPNAKTVRLR VSFSAVVFKA - 120
VADICKVLNI RRPEELSLLK PSSDYCKKKK KKEKNSKEPV IEDILNLESS STSSGSPVSP - 180
GLYSKTMTPT YDPINGTPAL STMTWFGDSP LTEQNCSVLA FSQPPPSPDV LADMFQPRSL - 240
VDKAKMNAGW LDSSRSLMEQ SIQEDEQLQL RFKYYTFFDL NPKYDAVRIN QLYEQARWAV - 300
LLEEIDCTEE EMLIFAALQY HISKLSQCAE IQDFATKSEV DEVEAALSSL EVTLEGGKAD - 360
NTLEDITDIP KLADYLKLFR PKKLMLKACK QYWFVFKDTS IAYFKNKELE QGEPIEKLNL - 420
RGCEIVPDVN VSGRKFGIKL LIPVADGMNE VYLRCDHEDQ YARWMAACIL ASKGKTMADS - 480
SYQPEVISIL SFLKMKNRNS SPLVASSLEN MDMNPECLVS PRCAKKHKSK QLAARILEAH - 540
HNVAQMPLVE AKLQFIQAWQ SLPEFGLTYY LVRFKGSKKD DILGVSYNRL IRIDAVTGIP - 600
VTTWRFANMK QWNVNWEIRQ VAIEFDQNVS IAFTCLSADC KIVHEYIGGY IFLSTRSKDQ - 660
NETLDEDLFH KLTGGQD
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| Functional narrative |
Involved in cell adhesion, possibly via its interaction with integrins.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | F1 Loop | | Location: | 141 - 250 | | Length: | 110 | | Region sequence: |
PSSDYCKKKKKKEKNSKEPVIEDILNLESSSTSSGSPVSPGLYSKTMTPTYDPINGTPAL
STMTWFGDSPLTEQNCSVLAFSQPPPSPDVLADMFQPRSLVDKAKMNAGW | | Modification type: | Native
| | PDB: | 2KMC:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
- Nuclear magnetic resonance (NMR) (298 K; pH: 6.5; protein (sample) 0.5 mM; sodium phosphate (buffer) 20 mM; NaCl (buffer) 50 mM; DTT 2 mM; 2H2O (v/v) 10 %)
| References:
- Goult BT, Bouaouina M, Harburger DS, Bate N, Patel B, Anthis NJ, Campbell ID, Calderwood DA, Barsukov IL, Roberts GC, Critchley DR. "The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation." J Mol Biol. 2009; 394(5): 944-56. PubMed: 19804783
| Comments:
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| References |
- Goult BT, Bouaouina M, Harburger DS, Bate N, Patel B, Anthis NJ, Campbell ID, Calderwood DA, Barsukov IL, Roberts GC, Critchley DR. "The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation." J Mol Biol. 2009; 394(5): 944-56. PubMed: 19804783
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